Atrial natriuretic peptide plasma levels during cardiac surgery

Paolo Flezzani, R. William McIntyre, Y. T. Xuan, Y. F. Su, John B. Leslie, W. David Watkins

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

In this investigation, the hypothesis was tested that patients with valvular heart disease have higher atrial natriuretic peptide (ANP) plasma levels than patients with coronary artery disease during cardiac surgery. Six patients scheduled for valve replacement (group V) and seven scheduled for coronary artery bypass grafting (CABG) (group C) were studied. ANP plasma levels and hemodynamic measurements were obtained at several times during surgery. ANP levels were elevated in both groups compared to those measured in healthy volunteers; and ANP levels in valvular patients were found to be higher than in the CABG patients. In addition, isotonic fluid loading, rewarming during cardiopulmonary bypass, and weaning from cardiopulmonary bypass increased ANP from baseline in group C. Mean arterial pressure and ANP levels correlated in group C. Ejection fraction, pulmonary artery diastolic pressure, and right atrial pressure did not correlate with ANP levels in either group. In conclusion, patients with valvular heart disease have higher ANP levels during surgery compared to patients with coronary artery disease. This difference probably relates to different pressure and volume loads on atrial tissue.

Original languageEnglish (US)
Pages (from-to)274-280
Number of pages7
JournalJournal of Cardiothoracic Anesthesia
Volume2
Issue number3
DOIs
StatePublished - 1988
Externally publishedYes

Fingerprint

Atrial Natriuretic Factor
Thoracic Surgery
Heart Valve Diseases
Cardiopulmonary Bypass
Coronary Artery Bypass
Coronary Artery Disease
Rewarming
Atrial Pressure
Pulmonary Artery
Healthy Volunteers
Arterial Pressure
Hemodynamics
Blood Pressure
Pressure

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine
  • Cardiology and Cardiovascular Medicine

Cite this

Flezzani, P., McIntyre, R. W., Xuan, Y. T., Su, Y. F., Leslie, J. B., & Watkins, W. D. (1988). Atrial natriuretic peptide plasma levels during cardiac surgery. Journal of Cardiothoracic Anesthesia, 2(3), 274-280. https://doi.org/10.1016/0888-6296(88)90305-5

Atrial natriuretic peptide plasma levels during cardiac surgery. / Flezzani, Paolo; McIntyre, R. William; Xuan, Y. T.; Su, Y. F.; Leslie, John B.; Watkins, W. David.

In: Journal of Cardiothoracic Anesthesia, Vol. 2, No. 3, 1988, p. 274-280.

Research output: Contribution to journalArticle

Flezzani, P, McIntyre, RW, Xuan, YT, Su, YF, Leslie, JB & Watkins, WD 1988, 'Atrial natriuretic peptide plasma levels during cardiac surgery', Journal of Cardiothoracic Anesthesia, vol. 2, no. 3, pp. 274-280. https://doi.org/10.1016/0888-6296(88)90305-5
Flezzani, Paolo ; McIntyre, R. William ; Xuan, Y. T. ; Su, Y. F. ; Leslie, John B. ; Watkins, W. David. / Atrial natriuretic peptide plasma levels during cardiac surgery. In: Journal of Cardiothoracic Anesthesia. 1988 ; Vol. 2, No. 3. pp. 274-280.
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