Atrial natriuretic peptide in hypothyroidism

R. S. Zimmerman, H. Gharib, D. Zimmerman, D. Heublein, John C Jr. Burnett

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

The effect of hypothyroidism on circulating levels of atrial natriuretic peptide (ANP) was studied in 11 hypothyroid patients (aged 11-65 yr; mean, 31 yr) and 13 normal subjects (aged 28-39 yr; mean, 32 yr). Plasma ANP was 32 ± 9 (±SD) pg/ml in normal subjects and 20 ± 5 pg/ml in the hypothyroid patients (P < 0.005). In 7 hypothyroid patients, plasma ANP levels were measured after 10-14 weeks of L-T4 therapy. ANP increased from 22 ± 5 to 46 ± 18 pg/ml (P < 0.02), along with an increase in mean serum T4 from 0.6 ± 0.5 to 8.1 to 2.5 μg/dl (P < 0.001). Thus, hypothyroidism is characterized by decreased circulating levels of ANP which are reversed by L-T4 therapy.

Original languageEnglish (US)
Pages (from-to)353-354
Number of pages2
JournalJournal of Clinical Endocrinology and Metabolism
Volume64
Issue number2
StatePublished - 1987

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Atrial Natriuretic Factor
Hypothyroidism
Plasmas
Therapeutics
Serum

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology, Diabetes and Metabolism

Cite this

Zimmerman, R. S., Gharib, H., Zimmerman, D., Heublein, D., & Burnett, J. C. J. (1987). Atrial natriuretic peptide in hypothyroidism. Journal of Clinical Endocrinology and Metabolism, 64(2), 353-354.

Atrial natriuretic peptide in hypothyroidism. / Zimmerman, R. S.; Gharib, H.; Zimmerman, D.; Heublein, D.; Burnett, John C Jr.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 64, No. 2, 1987, p. 353-354.

Research output: Contribution to journalArticle

Zimmerman, RS, Gharib, H, Zimmerman, D, Heublein, D & Burnett, JCJ 1987, 'Atrial natriuretic peptide in hypothyroidism', Journal of Clinical Endocrinology and Metabolism, vol. 64, no. 2, pp. 353-354.
Zimmerman RS, Gharib H, Zimmerman D, Heublein D, Burnett JCJ. Atrial natriuretic peptide in hypothyroidism. Journal of Clinical Endocrinology and Metabolism. 1987;64(2):353-354.
Zimmerman, R. S. ; Gharib, H. ; Zimmerman, D. ; Heublein, D. ; Burnett, John C Jr. / Atrial natriuretic peptide in hypothyroidism. In: Journal of Clinical Endocrinology and Metabolism. 1987 ; Vol. 64, No. 2. pp. 353-354.
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