Atrial natriuretic peptide frameshift mutation in familial atrial fibrillation

Denice M. Hodgson-Zingman, Margaret L. Karst, Leonid V. Zingman, Denise M. Heublein, Dawood Darbar, Kathleen J. Herron, Jeffrey D. Ballew, Mariza De Andrade, John C Jr. Burnett, Timothy Mark Olson

Research output: Contribution to journalArticle

209 Citations (Scopus)

Abstract

Atrial fibrillation is a common arrhythmia that is hereditary in a small subgroup of patients. In a family with 11 clinically affected members, we mapped an atrial fibrillation locus to chromosome 1p36-p35 and identified a heterozygous frameshift mutation in the gene encoding atrial natriuretic peptide. Circulating chimeric atrial natriuretic peptide (ANP) was detected in high concentration in subjects with the mutation, and shortened atrial action potentials were seen in an isolated heart model, creating a possible substrate for atrial fibrillation. This report implicates perturbation of the atrial natriuretic peptide-cyclic guanosine monophosphate (cGMP) pathway in cardiac electrical instability.

Original languageEnglish (US)
Pages (from-to)158-165
Number of pages8
JournalNew England Journal of Medicine
Volume359
Issue number2
DOIs
StatePublished - Jul 10 2008

Fingerprint

Frameshift Mutation
Atrial Natriuretic Factor
Atrial Fibrillation
Cyclic GMP
Action Potentials
Cardiac Arrhythmias
Chromosomes
Mutation
Genes

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Hodgson-Zingman, D. M., Karst, M. L., Zingman, L. V., Heublein, D. M., Darbar, D., Herron, K. J., ... Olson, T. M. (2008). Atrial natriuretic peptide frameshift mutation in familial atrial fibrillation. New England Journal of Medicine, 359(2), 158-165. https://doi.org/10.1056/NEJMoa0706300

Atrial natriuretic peptide frameshift mutation in familial atrial fibrillation. / Hodgson-Zingman, Denice M.; Karst, Margaret L.; Zingman, Leonid V.; Heublein, Denise M.; Darbar, Dawood; Herron, Kathleen J.; Ballew, Jeffrey D.; De Andrade, Mariza; Burnett, John C Jr.; Olson, Timothy Mark.

In: New England Journal of Medicine, Vol. 359, No. 2, 10.07.2008, p. 158-165.

Research output: Contribution to journalArticle

Hodgson-Zingman, DM, Karst, ML, Zingman, LV, Heublein, DM, Darbar, D, Herron, KJ, Ballew, JD, De Andrade, M, Burnett, JCJ & Olson, TM 2008, 'Atrial natriuretic peptide frameshift mutation in familial atrial fibrillation', New England Journal of Medicine, vol. 359, no. 2, pp. 158-165. https://doi.org/10.1056/NEJMoa0706300
Hodgson-Zingman DM, Karst ML, Zingman LV, Heublein DM, Darbar D, Herron KJ et al. Atrial natriuretic peptide frameshift mutation in familial atrial fibrillation. New England Journal of Medicine. 2008 Jul 10;359(2):158-165. https://doi.org/10.1056/NEJMoa0706300
Hodgson-Zingman, Denice M. ; Karst, Margaret L. ; Zingman, Leonid V. ; Heublein, Denise M. ; Darbar, Dawood ; Herron, Kathleen J. ; Ballew, Jeffrey D. ; De Andrade, Mariza ; Burnett, John C Jr. ; Olson, Timothy Mark. / Atrial natriuretic peptide frameshift mutation in familial atrial fibrillation. In: New England Journal of Medicine. 2008 ; Vol. 359, No. 2. pp. 158-165.
@article{88e4f2b4f38b473bb9f019572ea8c1dd,
title = "Atrial natriuretic peptide frameshift mutation in familial atrial fibrillation",
abstract = "Atrial fibrillation is a common arrhythmia that is hereditary in a small subgroup of patients. In a family with 11 clinically affected members, we mapped an atrial fibrillation locus to chromosome 1p36-p35 and identified a heterozygous frameshift mutation in the gene encoding atrial natriuretic peptide. Circulating chimeric atrial natriuretic peptide (ANP) was detected in high concentration in subjects with the mutation, and shortened atrial action potentials were seen in an isolated heart model, creating a possible substrate for atrial fibrillation. This report implicates perturbation of the atrial natriuretic peptide-cyclic guanosine monophosphate (cGMP) pathway in cardiac electrical instability.",
author = "Hodgson-Zingman, {Denice M.} and Karst, {Margaret L.} and Zingman, {Leonid V.} and Heublein, {Denise M.} and Dawood Darbar and Herron, {Kathleen J.} and Ballew, {Jeffrey D.} and {De Andrade}, Mariza and Burnett, {John C Jr.} and Olson, {Timothy Mark}",
year = "2008",
month = "7",
day = "10",
doi = "10.1056/NEJMoa0706300",
language = "English (US)",
volume = "359",
pages = "158--165",
journal = "New England Journal of Medicine",
issn = "1533-4406",
publisher = "Massachussetts Medical Society",
number = "2",

}

TY - JOUR

T1 - Atrial natriuretic peptide frameshift mutation in familial atrial fibrillation

AU - Hodgson-Zingman, Denice M.

AU - Karst, Margaret L.

AU - Zingman, Leonid V.

AU - Heublein, Denise M.

AU - Darbar, Dawood

AU - Herron, Kathleen J.

AU - Ballew, Jeffrey D.

AU - De Andrade, Mariza

AU - Burnett, John C Jr.

AU - Olson, Timothy Mark

PY - 2008/7/10

Y1 - 2008/7/10

N2 - Atrial fibrillation is a common arrhythmia that is hereditary in a small subgroup of patients. In a family with 11 clinically affected members, we mapped an atrial fibrillation locus to chromosome 1p36-p35 and identified a heterozygous frameshift mutation in the gene encoding atrial natriuretic peptide. Circulating chimeric atrial natriuretic peptide (ANP) was detected in high concentration in subjects with the mutation, and shortened atrial action potentials were seen in an isolated heart model, creating a possible substrate for atrial fibrillation. This report implicates perturbation of the atrial natriuretic peptide-cyclic guanosine monophosphate (cGMP) pathway in cardiac electrical instability.

AB - Atrial fibrillation is a common arrhythmia that is hereditary in a small subgroup of patients. In a family with 11 clinically affected members, we mapped an atrial fibrillation locus to chromosome 1p36-p35 and identified a heterozygous frameshift mutation in the gene encoding atrial natriuretic peptide. Circulating chimeric atrial natriuretic peptide (ANP) was detected in high concentration in subjects with the mutation, and shortened atrial action potentials were seen in an isolated heart model, creating a possible substrate for atrial fibrillation. This report implicates perturbation of the atrial natriuretic peptide-cyclic guanosine monophosphate (cGMP) pathway in cardiac electrical instability.

UR - http://www.scopus.com/inward/record.url?scp=46949093558&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=46949093558&partnerID=8YFLogxK

U2 - 10.1056/NEJMoa0706300

DO - 10.1056/NEJMoa0706300

M3 - Article

C2 - 18614783

AN - SCOPUS:46949093558

VL - 359

SP - 158

EP - 165

JO - New England Journal of Medicine

JF - New England Journal of Medicine

SN - 1533-4406

IS - 2

ER -