Atrial natriuretic factor: Implications in congestive heart failure and hypertension

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The physiological actions of the atrial peptide system are discussed in relation to its potential role in the aetiology and treatment of hypertension and congestive heart failure (CHF). Atrial natriuretic factor (ANF) exerts marked natriuretic, diuretic and vasodilatory effects and has been demonstrated to reduce blood pressure by several mechanisms, actions which serve to protect the central circulation against volume and pressure overload. It was initially believed that CHF may relate to a deficiency of ANF, but studies of experimentally induced and human CHF have shown elevated levels of circulating ANF, reflecting a compensatory increase in response to reduced cardiac output. In contrast, plasma levels of ANF in hypertension not complicated by CHF are normal and it might be speculated that hypertension reflects an attenuated ANF response to increased cardiac volume and/or pressure. ANF may play an important role in these cardiovascular disease states and, with the availability of synthetic ANF analogues, may also have therapeutic potential.

Original languageEnglish (US)
Pages (from-to)41-46
Number of pages6
JournalJournal of Human Hypertension
Volume3
Issue numberSUPPL. 1
StatePublished - 1989

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Atrial Natriuretic Factor
Heart Failure
Hypertension
Pressure
Cardiac Volume
Diuretics
Cardiac Output
Cardiovascular Diseases
Blood Pressure

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Atrial natriuretic factor : Implications in congestive heart failure and hypertension. / Burnett, John C Jr.

In: Journal of Human Hypertension, Vol. 3, No. SUPPL. 1, 1989, p. 41-46.

Research output: Contribution to journalArticle

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