Atrial Endocrine Function in Humans with Artificial Hearts

Thomas R. Schwab; Brooks S. Edwards; William C. Devries; Robert S. Zimmerman; John C. Burnett

doi:10.1056/NEJM198611273152207

Atrial Endocrine Function in Humans with Artificial Hearts

Thomas R. Schwab, Brooks S. Edwards, William C. Devries, Robert S. Zimmerman, John C. Burnett

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

THE artificial heart is currently under investigation as a means to restore cardiac function in patients with end-stage heart failure. During implantation, the Jarvik-7 artificial heart is anastomosed to the native pulmonary artery, aorta, and cardiac atria.¹ Postoperatively, approximately 95 percent of the native atrial tissue remains in situ. The atria play a key part in the control of body-fluid homeostasis by monitoring blood volume and initiating appropriate changes in urine flow and sodium excretion. Until recently the polyuria that may accompany atrial tachycardia and atrial distension has been attributed to reflex stimulation of subendocardial neuronal stretch receptors.²^,³ In 1981…

Original language	English (US)
Pages (from-to)	1398-1401
Number of pages	4
Journal	New England Journal of Medicine
Volume	315
Issue number	22
DOIs	https://doi.org/10.1056/NEJM198611273152207
State	Published - Nov 27 1986

ASJC Scopus subject areas

General Medicine

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abstract = "THE artificial heart is currently under investigation as a means to restore cardiac function in patients with end-stage heart failure. During implantation, the Jarvik-7 artificial heart is anastomosed to the native pulmonary artery, aorta, and cardiac atria.1 Postoperatively, approximately 95 percent of the native atrial tissue remains in situ. The atria play a key part in the control of body-fluid homeostasis by monitoring blood volume and initiating appropriate changes in urine flow and sodium excretion. Until recently the polyuria that may accompany atrial tachycardia and atrial distension has been attributed to reflex stimulation of subendocardial neuronal stretch receptors.2,3 In 1981…",

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AU - Edwards, Brooks S.

AU - Devries, William C.

AU - Zimmerman, Robert S.

AU - Burnett, John C.

PY - 1986/11/27

Y1 - 1986/11/27

N2 - THE artificial heart is currently under investigation as a means to restore cardiac function in patients with end-stage heart failure. During implantation, the Jarvik-7 artificial heart is anastomosed to the native pulmonary artery, aorta, and cardiac atria.1 Postoperatively, approximately 95 percent of the native atrial tissue remains in situ. The atria play a key part in the control of body-fluid homeostasis by monitoring blood volume and initiating appropriate changes in urine flow and sodium excretion. Until recently the polyuria that may accompany atrial tachycardia and atrial distension has been attributed to reflex stimulation of subendocardial neuronal stretch receptors.2,3 In 1981…

AB - THE artificial heart is currently under investigation as a means to restore cardiac function in patients with end-stage heart failure. During implantation, the Jarvik-7 artificial heart is anastomosed to the native pulmonary artery, aorta, and cardiac atria.1 Postoperatively, approximately 95 percent of the native atrial tissue remains in situ. The atria play a key part in the control of body-fluid homeostasis by monitoring blood volume and initiating appropriate changes in urine flow and sodium excretion. Until recently the polyuria that may accompany atrial tachycardia and atrial distension has been attributed to reflex stimulation of subendocardial neuronal stretch receptors.2,3 In 1981…

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Atrial Endocrine Function in Humans with Artificial Hearts

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