Atractylodes japonica suppresses lipopolysaccharide-stimulated expressions of inducible nitric oxide synthase and cyclooxygenase-2 in RAW 264.7 macrophages

Mi Hyeon Jang, Min Chul Shin, Ye Jin Kim, Chang Ju Kim, Yeunhee Kim, Ee Hwa Kim

Research output: Contribution to journalArticle

20 Scopus citations


Atractylodes japonica has traditionally been used for the treatment of pain and arthritis. The effect of Atractylodes japonica against lipopolysaccharide- induced inflammation was investigated using reverse transcription-polymerase chain reaction (RT-PCR), nitric oxide detection, and prostaglandin E2 (PGE2) immunoassay in mouse RAW 264.7 macrophages. The aqueous extract of Atractylodes japonica suppressed nitric oxide production and PGE 2 synthesis by inhibition of the lipopolysaccharide-stimulated enhancement of inducible nitric oxide synthase and cyclooxygenase-2 mRNAs expressions in RAW 264.7 macrophages. These results suggest that Atractylodes japonica exerts anti-inflammatory and analgesic effects probably by suppression of the inducible nitric oxide synthase and cyclooxygenase-2 expressions.

Original languageEnglish (US)
Pages (from-to)324-327
Number of pages4
JournalBiological and Pharmaceutical Bulletin
Issue number3
StatePublished - Mar 1 2004



  • Atractylodes japonica
  • Cyclooxygenase-2
  • Inducible nitric oxide synthase
  • Lipopolysaccharide

ASJC Scopus subject areas

  • Pharmacology
  • Pharmaceutical Science

Cite this