ATP-sensitive potassium (K_ATP) channel openers diazoxide and nicorandil lower intraocular pressure by activating the Erk1/2 signaling pathway

Medicine & Life Sciences

• Nicorandil 82%
• Diazoxide 77%
• KATP Channels 71%
• Intraocular Pressure 54%
• U 0126 28%
• Anterior Eye Segment 15%
• Trabecular Meshwork 14%
• Optic Nerve Diseases 13%
• Eye 13%
• Glaucoma 10%
• Disease Progression 8%
• Electrons 8%
• Perfusion 8%
• Phosphorylation 7%
• Western Blotting 7%
• Pressure 7%
• Therapeutics 5%

Chemical Compounds

• Nicorandil 100%
• Diazoxide 96%
• Intraocular 79%
• U0126 43%
• Pressure 32%
• Reduction 15%
• Ocular 14%

Agriculture & Biology

• diazoxide 92%
• potassium channels 63%
• eyes 26%
• glaucoma 15%
• antihypertensive effect 14%
• disease progression 14%
• optics 12%
• risk factors 10%
• phosphorylation 9%
• nerve tissue 9%
• ultrastructure 9%
• Western blotting 9%
• adverse effects 9%
• therapeutics 8%
• electrons 8%
• mice 6%
• cells 3%