Atomic force microscopy studies on DNA structural changes induced by vincristine sulfate and aspirin

Yi Zhu, Hu Zeng, Jianming Xie, Long Ba, Xiang Gao, Zuhong Lu

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

We report that atomic force microscopy (AFM) studies on structural variations of a linear plasmid DNA interact with various concentrations of vincristine sulfate and aspirin. The different binding images show that vincrinstine sulfate binding DNA chains caused some loops and cleavages of the DNA fragments, whereas aspirin interaction caused the width changes and conformational transition of the DNA fragments. Two different DNA structural alternations could be explained by the different mechanisms of the interactions with these two components. Our work indicates that the AFM is a powerful tool in studying the interaction between DNA and small molecules.

Original languageEnglish (US)
Pages (from-to)286-290
Number of pages5
JournalMicroscopy and Microanalysis
Volume10
Issue number2
DOIs
StatePublished - Apr 1 2004

Keywords

  • AFM
  • Aspirin
  • DNA structural change
  • Vincristine sulfate

ASJC Scopus subject areas

  • Instrumentation

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