Atherosclerotic renal artery stenosis: Current status

Soon Hyo Kwon, Lilach O. Lerman

Research output: Contribution to journalReview article

9 Scopus citations

Abstract

Atherosclerotic renal artery stenosis (ARAS) remains a major cause of secondary hypertension and kidney failure. Randomized prospective trials show that medical treatment should constitute the main therapeutic approach in ARAS. Regardless of intensive treatment and adequate blood pressure control, however, renal and extrarenal complications are not uncommon. Yet, the precise mechanisms, accurate detection, and optimal treatment in ARAS remain elusive. Strategies oriented to early detection and targeting these pathogenic pathways might prevent development of clinical end points. Here, we review the results of recent clinical trials, current understanding of the pathogenic mechanisms, novel imaging techniques to assess kidney damage in ARAS, and treatment options.

Original languageEnglish (US)
Pages (from-to)224-231
Number of pages8
JournalAdvances in Chronic Kidney Disease
Volume22
Issue number3
DOIs
StatePublished - May 1 2015

Keywords

  • Atherosclerosis
  • Hypertension
  • Inflammation
  • Ischemia
  • Renal artery obstruction

ASJC Scopus subject areas

  • Nephrology

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