Atherosclerotic plaque destabilization in Mice: A comparative study

Helene Hartwig, Carlos Silvestre-Roig, Jeffrey Hendrikse, Linda Beckers, Nicole Paulin, Kim Van Der Heiden, Quinte Braster, Maik Drechsler, Mat J. Daemen, Esther Lutgens, Oliver Soehnlein

Research output: Contribution to journalArticlepeer-review

Abstract

Atherosclerosis-Associated diseases are the main cause ofmortality and morbidity in western societies. The progression of atherosclerosis is a dynamic process evolving from early to advanced lesions thatmay become rupture-prone vulnerable plaques. Acute coronary syndromes are the clinical manifestation of life-Threatening thrombotic events associated with high-risk vulnerable plaques. Hyperlipidemic mouse models have been extensively used in studying the mechanisms controlling initiation and progression of atherosclerosis. However, the understanding of mechanisms leading to atherosclerotic plaque destabilization has been hampered by the lack of proper animalmodelsmimicking this process. Although various mouse models generate atherosclerotic plaques with histological features of human advanced lesions, a consensus model to study atherosclerotic plaque destabilization is still lacking. Hence, we studied the degree and features of plaque vulnerability in different mouse models of atherosclerotic plaque destabilization and find that the model based on the placement of a shear stress modifier in combination with hypercholesterolemia represent with high incidence the most human like lesions compared to the other models.

Original languageEnglish (US)
Article numbere0141019
JournalPloS one
Volume10
Issue number10
DOIs
StatePublished - Oct 22 2015

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)
  • General

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