TY - CHAP
T1 - Atherosclerosis and Inflammatory Heart Disease
AU - Fairweather, De Lisa
N1 - Publisher Copyright:
© 2012, Springer Science+Business Media, LLC.
PY - 2012
Y1 - 2012
N2 - Cardiovascular disease (CVD) is the leading cause of mortality worldwide, with atherosclerosis accounting for most deaths. Inflammation is a key component in the pathogenesis of CVDs such as atherosclerosis, stroke, myocarditis, dilated cardiomyopathy, and heart failure. A number of recent clinical and animal model findings suggest that the pathogenesis of autoimmune and CVDs may be linked. Many potentially modifiable risk factors like diet, tobacco smoking, and infections have been associated with increased cardiovascular risk for both atherosclerosis and several autoimmune diseases including myocarditis, systemic lupus erythematosus, and rheumatoid arthritis. Although many autoimmune diseases are more prevalent in women, the risk for developing CVD remains elevated in men. Future studies should examine sex differences in CVD biomarkers following infection and/or toxicant exposure.
AB - Cardiovascular disease (CVD) is the leading cause of mortality worldwide, with atherosclerosis accounting for most deaths. Inflammation is a key component in the pathogenesis of CVDs such as atherosclerosis, stroke, myocarditis, dilated cardiomyopathy, and heart failure. A number of recent clinical and animal model findings suggest that the pathogenesis of autoimmune and CVDs may be linked. Many potentially modifiable risk factors like diet, tobacco smoking, and infections have been associated with increased cardiovascular risk for both atherosclerosis and several autoimmune diseases including myocarditis, systemic lupus erythematosus, and rheumatoid arthritis. Although many autoimmune diseases are more prevalent in women, the risk for developing CVD remains elevated in men. Future studies should examine sex differences in CVD biomarkers following infection and/or toxicant exposure.
KW - Constrictive Pericarditis
KW - Rheumatoid Arthritis
KW - Rheumatoid Arthritis Patient
KW - Systemic Lupus Erythematosus
KW - Systemic Lupus Erythematosus Patient
UR - http://www.scopus.com/inward/record.url?scp=85091524293&partnerID=8YFLogxK
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U2 - 10.1007/978-1-61779-812-2_11
DO - 10.1007/978-1-61779-812-2_11
M3 - Chapter
AN - SCOPUS:85091524293
T3 - Molecular and Integrative Toxicology
SP - 271
EP - 289
BT - Molecular and Integrative Toxicology
PB - Springer Science+Business Media B.V.
ER -