Atherosclerosis and Inflammatory Heart Disease

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Abstract

Cardiovascular disease (CVD) is the leading cause of mortality ­worldwide, with atherosclerosis accounting for most deaths. Inflammation is a key component in the pathogenesis of CVDs such as atherosclerosis, stroke, myocarditis, dilated cardiomyopathy, and heart failure. A number of recent clinical and animal model findings suggest that the pathogenesis of autoimmune and CVDs may be linked. Many potentially modifiable risk factors like diet, tobacco smoking, and infections have been associated with increased cardiovascular risk for both atherosclerosis and several autoimmune diseases including myocarditis, systemic lupus erythematosus, and rheumatoid arthritis. Although many autoimmune diseases are more prevalent in women, the risk for developing CVD remains elevated in men. Future studies should examine sex differences in CVD biomarkers following infection and/or toxicant exposure.

Original languageEnglish (US)
Title of host publicationMolecular and Integrative Toxicology
PublisherSpringer Science+Business Media B.V.
Pages271-289
Number of pages19
DOIs
StatePublished - 2012

Publication series

NameMolecular and Integrative Toxicology
ISSN (Print)2168-4219
ISSN (Electronic)2168-4235

Keywords

  • Constrictive Pericarditis
  • Rheumatoid Arthritis
  • Rheumatoid Arthritis Patient
  • Systemic Lupus Erythematosus
  • Systemic Lupus Erythematosus Patient

ASJC Scopus subject areas

  • Immunology and Allergy
  • Pharmacology (medical)
  • Drug Discovery
  • Toxicology

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