ATHEROEMBOLIC RENAL DISEASE CAUSES HYPOCOMPLEMENTAEMIA

Fernando G. Cosio, Richard A. Zager, Hari M. Sharma

Research output: Contribution to journalArticlepeer-review

108 Scopus citations

Abstract

7 patients with atheroembolic renal disease were found to have hypocomplementaemia. Evidence obtained in an experimental model of atheroembolic disease shows that the hypocomplementaemia is the result of complement activation by the atheromatous material in vivo. In addition to hypocomplementaemia, 6 patients had thrombocytopenia and 5 had eosinophilia. These observations indicate that atheroembolic disease should now be included in the differential diagnosis of hypocomplementaemia. In addition, atheroembolic disease should be considered in patients presenting with a combination of multisystem disease, hypocomplementaemia, thrombocytopenia, and eosinophilia-a syndrome which previously would have been regarded as diagnostic of immune-complex-mediated vasculitis.

Original languageEnglish (US)
Pages (from-to)118-121
Number of pages4
JournalThe Lancet
Volume326
Issue number8447
DOIs
StatePublished - Jul 20 1985

ASJC Scopus subject areas

  • Medicine(all)

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