ATHEROEMBOLIC RENAL DISEASE CAUSES HYPOCOMPLEMENTAEMIA

Fernando G Cosio, RichardA Zager, HariM Sharma

Research output: Contribution to journalArticle

107 Citations (Scopus)

Abstract

7 patients with atheroembolic renal disease were found to have hypocomplementaemia. Evidence obtained in an experimental model of atheroembolic disease shows that the hypocomplementaemia is the result of complement activation by the atheromatous material in vivo. In addition to hypocomplementaemia, 6 patients had thrombocytopenia and 5 had eosinophilia. These observations indicate that atheroembolic disease should now be included in the differential diagnosis of hypocomplementaemia. In addition, atheroembolic disease should be considered in patients presenting with a combination of multisystem disease, hypocomplementaemia, thrombocytopenia, and eosinophilia-a syndrome which previously would have been regarded as diagnostic of immune-complex-mediated vasculitis.

Original languageEnglish (US)
Pages (from-to)118-121
Number of pages4
JournalThe Lancet
Volume326
Issue number8447
DOIs
StatePublished - Jul 20 1985
Externally publishedYes

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Kidney
Eosinophilia
Thrombocytopenia
Complement Activation
Vasculitis
Antigen-Antibody Complex
Differential Diagnosis
Theoretical Models

ASJC Scopus subject areas

  • Medicine(all)

Cite this

ATHEROEMBOLIC RENAL DISEASE CAUSES HYPOCOMPLEMENTAEMIA. / Cosio, Fernando G; Zager, RichardA; Sharma, HariM.

In: The Lancet, Vol. 326, No. 8447, 20.07.1985, p. 118-121.

Research output: Contribution to journalArticle

Cosio, FG, Zager, R & Sharma, H 1985, 'ATHEROEMBOLIC RENAL DISEASE CAUSES HYPOCOMPLEMENTAEMIA', The Lancet, vol. 326, no. 8447, pp. 118-121. https://doi.org/10.1016/S0140-6736(85)90225-9
Cosio, Fernando G ; Zager, RichardA ; Sharma, HariM. / ATHEROEMBOLIC RENAL DISEASE CAUSES HYPOCOMPLEMENTAEMIA. In: The Lancet. 1985 ; Vol. 326, No. 8447. pp. 118-121.
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