Ataxia in the setting of complicated enteropathy: Double jeopardy

P. N. Shams, A. Waldman, A. Dogan, J. M. MacKenzie, G. T. Plant

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

The differential diagnosis of subacute onset ataxia in the setting of enteropathy is wide. A 54 year old patient with a pancerebellar syndrome and known ulcerative jejunoileitis is described. Small bowel biopsy showed evidence of enteropathy associated T cell lymphoma and subsequent neuropathological analysis and immunophenotyping confirmed metastasis of this tumour to the cerebellum. The presence of anti-gliadin antibodies and MRI evidence of a more longstanding process suggested additional immunologically mediated cerebellar dysfunction. Lymphomatous involvement of the CNS is rare in patients with complicated enteropathies, and has not been previously reported to involve the cerebellar parenchyma. This diagnostic possibility should be borne in mind before attributing cerebellar dysfunction in patients with the coeliac related enteropathies to nutritional compromise or immunological dysfunction (gluten ataxia) alone.

Original languageEnglish (US)
Pages (from-to)527-529
Number of pages3
JournalJournal of Neurology Neurosurgery and Psychiatry
Volume72
Issue number4
DOIs
StatePublished - 2002

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology
  • Psychiatry and Mental health

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