At long last: Fatal Forty DDI: Ziprasidone, moxifloxacin, CYP3A4, CYP2D6, QT-prolongation

Kristen B. McCullough, Wayne T. Nicholson

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

This case discusses two separate drug-drug interactions. There is a pharmacokinetic interaction between fluoxetine and cylcobenzaprine and a pharmacodynamic interaction with droperidol. The drug interactions are compounded by an electrolyte imbalance, resulting in prolongation of the QTc.

Original languageEnglish (US)
Title of host publicationA Case Approach to Perioperative Drug-Drug Interactions
PublisherSpringer New York
Pages807-811
Number of pages5
ISBN (Print)9781461474951, 9781461474944
DOIs
StatePublished - Sep 15 2015

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Cytochrome P-450 CYP3A
Cytochrome P-450 CYP2D6
Drug Interactions
Droperidol
Fluoxetine
Electrolytes
Pharmacokinetics
Pharmaceutical Preparations
ziprasidone
moxifloxacin

ASJC Scopus subject areas

  • Medicine(all)

Cite this

McCullough, K. B., & Nicholson, W. T. (2015). At long last: Fatal Forty DDI: Ziprasidone, moxifloxacin, CYP3A4, CYP2D6, QT-prolongation. In A Case Approach to Perioperative Drug-Drug Interactions (pp. 807-811). Springer New York. https://doi.org/10.1007/978-1-4614-7495-1_181

At long last : Fatal Forty DDI: Ziprasidone, moxifloxacin, CYP3A4, CYP2D6, QT-prolongation. / McCullough, Kristen B.; Nicholson, Wayne T.

A Case Approach to Perioperative Drug-Drug Interactions. Springer New York, 2015. p. 807-811.

Research output: Chapter in Book/Report/Conference proceedingChapter

McCullough, KB & Nicholson, WT 2015, At long last: Fatal Forty DDI: Ziprasidone, moxifloxacin, CYP3A4, CYP2D6, QT-prolongation. in A Case Approach to Perioperative Drug-Drug Interactions. Springer New York, pp. 807-811. https://doi.org/10.1007/978-1-4614-7495-1_181
McCullough KB, Nicholson WT. At long last: Fatal Forty DDI: Ziprasidone, moxifloxacin, CYP3A4, CYP2D6, QT-prolongation. In A Case Approach to Perioperative Drug-Drug Interactions. Springer New York. 2015. p. 807-811 https://doi.org/10.1007/978-1-4614-7495-1_181
McCullough, Kristen B. ; Nicholson, Wayne T. / At long last : Fatal Forty DDI: Ziprasidone, moxifloxacin, CYP3A4, CYP2D6, QT-prolongation. A Case Approach to Perioperative Drug-Drug Interactions. Springer New York, 2015. pp. 807-811
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