Asymmetry in melanocytic lesions

a morphometric analysis.

Thomas J Flotte, L. Lamberti

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The purpose of this study was to establish a morphometric technique that would approximate the subjective histological criteria of asymmetry in the diagnosis of malignant melanoma. The dermal and epidermal outlines of 52 consecutive malignant melanomas and 56 consecutive melanocytic nevi were digitized and analyzed for morphometric parameters of size, coordinates, and shape. The two parameters that showed the most significant discriminatory functions were the differences in the center of masses of the epidermal and dermal components in the horizontal dimension and the length of the longest segment in the lesion.

Original languageEnglish (US)
Pages (from-to)333-336
Number of pages4
JournalModern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
Volume5
Issue number3
StatePublished - May 1992
Externally publishedYes

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Melanoma
Pigmented Nevus
Skin

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

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title = "Asymmetry in melanocytic lesions: a morphometric analysis.",
abstract = "The purpose of this study was to establish a morphometric technique that would approximate the subjective histological criteria of asymmetry in the diagnosis of malignant melanoma. The dermal and epidermal outlines of 52 consecutive malignant melanomas and 56 consecutive melanocytic nevi were digitized and analyzed for morphometric parameters of size, coordinates, and shape. The two parameters that showed the most significant discriminatory functions were the differences in the center of masses of the epidermal and dermal components in the horizontal dimension and the length of the longest segment in the lesion.",
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AU - Lamberti, L.

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N2 - The purpose of this study was to establish a morphometric technique that would approximate the subjective histological criteria of asymmetry in the diagnosis of malignant melanoma. The dermal and epidermal outlines of 52 consecutive malignant melanomas and 56 consecutive melanocytic nevi were digitized and analyzed for morphometric parameters of size, coordinates, and shape. The two parameters that showed the most significant discriminatory functions were the differences in the center of masses of the epidermal and dermal components in the horizontal dimension and the length of the longest segment in the lesion.

AB - The purpose of this study was to establish a morphometric technique that would approximate the subjective histological criteria of asymmetry in the diagnosis of malignant melanoma. The dermal and epidermal outlines of 52 consecutive malignant melanomas and 56 consecutive melanocytic nevi were digitized and analyzed for morphometric parameters of size, coordinates, and shape. The two parameters that showed the most significant discriminatory functions were the differences in the center of masses of the epidermal and dermal components in the horizontal dimension and the length of the longest segment in the lesion.

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