(A)symmetric stem cell replication and cancer

David M Dingli, Arne Traulsen, Fransizka Michor

Research output: Contribution to journalArticle

85 Citations (Scopus)

Abstract

Most tissues in metazoans undergo continuous turnover due to cell death or epithelial shedding. Since cellular replication is associated with an inherent risk of mutagenesis, tissues are maintained by a small group of stem cells (SCs) that replicate slowly to maintain their own population and that give rise to differentiated cells. There is increasing evidence that many tumors are also maintained by a small population of cancer stem cells that may arise by mutations from normal SCs. SC replication can be either symmetric or asymmetric. The former can lead to expansion of the SC pool. We describe a simple model to evaluate the impact of (a)symmetric SC replication on the expansion of mutant SCs and to show that mutations that increase the probability of asymmetric replication can lead to rapid mutant SC expansion in the absence of a selective fitness advantage. Mutations in several genes can lead to this process and may be at the root of the carcinogenic process.

Original languageEnglish (US)
Pages (from-to)482-487
Number of pages6
JournalPLoS Computational Biology
Volume3
Issue number3
DOIs
StatePublished - Mar 2007

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Stem Cells
Neoplastic Stem Cells
Stem cells
Replication
stem cells
cancer
Cancer
stem
neoplasms
mutation
Mutation
Mutant
Tissue
mutants
Mutagenesis
Cell
Cell death
Population
mutagenesis
tumor

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Ecology
  • Molecular Biology
  • Genetics
  • Ecology, Evolution, Behavior and Systematics
  • Modeling and Simulation
  • Computational Theory and Mathematics

Cite this

(A)symmetric stem cell replication and cancer. / Dingli, David M; Traulsen, Arne; Michor, Fransizka.

In: PLoS Computational Biology, Vol. 3, No. 3, 03.2007, p. 482-487.

Research output: Contribution to journalArticle

Dingli, David M ; Traulsen, Arne ; Michor, Fransizka. / (A)symmetric stem cell replication and cancer. In: PLoS Computational Biology. 2007 ; Vol. 3, No. 3. pp. 482-487.
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