Astrocytic glutamate transporter 1 (GLT1) deficient mice exhibit repetitive behaviors

Yun Fang Jia, Katheryn Wininger, Lee Peyton, Ada Man Choi Ho, Doo Sup Choi

Research output: Contribution to journalArticle

Abstract

Glutamatergic dysregulation is known to contribute to obsessive-compulsive disorder (OCD). Astrocytic glutamate transporter 1 (GLT1) is responsible for the majority of glutamate clearance. However, the role of GLT1 in OCD-like behavior remains unclear. Here, we found that astrocytic GLT1 deficient mice showed increased wheel running activity but reduced home cage activity. Notably, they exhibited elevated grooming/rearing time and increased repetitive behavior counts in contextual and cued fear conditioning. In addition, they showed increased rearing counts in the metabolic chamber, and also augmented rearing time and jumping counts in the open field test. Taken together, our findings suggest that astrocytic GLT1 deficiency promotes OCD-like repetitive behaviors.

Original languageEnglish (US)
Article number112906
JournalBehavioural Brain Research
Volume396
DOIs
StatePublished - Jan 1 2021

Keywords

  • Fear conditioning
  • Glutamate transporter 1 (GLT1)
  • Grooming
  • Obsessive-compulsive disorder (OCD)
  • Repetitive behavior
  • Wheel running activity

ASJC Scopus subject areas

  • Behavioral Neuroscience

Fingerprint Dive into the research topics of 'Astrocytic glutamate transporter 1 (GLT1) deficient mice exhibit repetitive behaviors'. Together they form a unique fingerprint.

  • Cite this