Asthma status and waning of measles antibody concentrations after measles immunization

Kwang Ha Yoo, Robert M. Jacobson, Gregory A. Poland, Amy Weaver, Linda Lee, Titus Chang, Young J Juhn

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Background: Asthmatics have increased risks of common and serious microbial infections including vaccine preventable diseases. Little is known about whether asthma influences waning of humoral immunity. We assessed whether asthma status influences waning of anti-measles virus antibody concentrations over time. Methods: The study used a cross-sectional study cohort of healthy children who had been immunized with 1 dose of MMR-II at age approximately 15 months. Between 5 and 12 years of age, measles vaccine virus-specific antibody (IgG) values were measured by enzyme immunoassay and considered seropositive if the enzyme immunoassay index unit was ≥ 1. The medical records were reviewed to determine asthma status during the first 18 years of life by applying predetermined criteria for asthma. A least squares regression model was used to evaluate the effect of asthma status on the relationship between measles antibody titer and time elapsed between the initial measles vaccination and measurement of measles antibody concentrations. Results: Of the 838 eligible children, 281 (34%) met criteria for asthma. Measles antibody waned over time (r = -0.19, P < 0.001), specifically more rapidly in asthmatics (r = -0.30, P < 0.001, a decrease of -0.114 unit per year) than nonasthmatics (r = -0.13, P = 0.002, a decrease of -0.046 unit per year; P value for interaction = 0.010). This differential waning rate resulted in a lower mean (SD) measles antibody concentration [1.42 (0.67) vs. 1.67 (0.69), P = 0.008] and lower seropositivity rate (73% vs. 84%, P = 0.038) in asthmatics than nonasthmatics starting around 9.3 years after the initial measles vaccination. Conclusion: Asthma status is associated with waning kinetics of measles antibody among children.

Original languageEnglish (US)
Pages (from-to)1016-1022
Number of pages7
JournalPediatric Infectious Disease Journal
Volume33
Issue number10
DOIs
StatePublished - 2014

Fingerprint

Measles
Immunization
Asthma
Antibodies
Measles virus
Immunoenzyme Techniques
Vaccination
Measles Vaccine
Humoral Immunity
Least-Squares Analysis
Medical Records
Vaccines
Cross-Sectional Studies
Immunoglobulin G
Infection

Keywords

  • Asthma
  • Epidemiology
  • Humoral immunity
  • Measles
  • Waning

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Infectious Diseases
  • Microbiology (medical)

Cite this

Asthma status and waning of measles antibody concentrations after measles immunization. / Yoo, Kwang Ha; Jacobson, Robert M.; Poland, Gregory A.; Weaver, Amy; Lee, Linda; Chang, Titus; Juhn, Young J.

In: Pediatric Infectious Disease Journal, Vol. 33, No. 10, 2014, p. 1016-1022.

Research output: Contribution to journalArticle

Yoo, Kwang Ha ; Jacobson, Robert M. ; Poland, Gregory A. ; Weaver, Amy ; Lee, Linda ; Chang, Titus ; Juhn, Young J. / Asthma status and waning of measles antibody concentrations after measles immunization. In: Pediatric Infectious Disease Journal. 2014 ; Vol. 33, No. 10. pp. 1016-1022.
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abstract = "Background: Asthmatics have increased risks of common and serious microbial infections including vaccine preventable diseases. Little is known about whether asthma influences waning of humoral immunity. We assessed whether asthma status influences waning of anti-measles virus antibody concentrations over time. Methods: The study used a cross-sectional study cohort of healthy children who had been immunized with 1 dose of MMR-II at age approximately 15 months. Between 5 and 12 years of age, measles vaccine virus-specific antibody (IgG) values were measured by enzyme immunoassay and considered seropositive if the enzyme immunoassay index unit was ≥ 1. The medical records were reviewed to determine asthma status during the first 18 years of life by applying predetermined criteria for asthma. A least squares regression model was used to evaluate the effect of asthma status on the relationship between measles antibody titer and time elapsed between the initial measles vaccination and measurement of measles antibody concentrations. Results: Of the 838 eligible children, 281 (34{\%}) met criteria for asthma. Measles antibody waned over time (r = -0.19, P < 0.001), specifically more rapidly in asthmatics (r = -0.30, P < 0.001, a decrease of -0.114 unit per year) than nonasthmatics (r = -0.13, P = 0.002, a decrease of -0.046 unit per year; P value for interaction = 0.010). This differential waning rate resulted in a lower mean (SD) measles antibody concentration [1.42 (0.67) vs. 1.67 (0.69), P = 0.008] and lower seropositivity rate (73{\%} vs. 84{\%}, P = 0.038) in asthmatics than nonasthmatics starting around 9.3 years after the initial measles vaccination. Conclusion: Asthma status is associated with waning kinetics of measles antibody among children.",
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AU - Chang, Titus

AU - Juhn, Young J

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