Associations of self-reported allergic diseases and musculoskeletal problems in children. A US population-based study

Benjamin J. Barrick, Somya Jalan, Megha M Tollefson, Todd A. Milbrandt, A. Noelle Larson, Matthew A Rank, Christine M. Lohse, Dawn Marie R. Davis

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background: Previous studies have found increased rates of musculoskeletal problems in adults with allergic disease, but whether this association holds true for children is unknown. Objective: To investigate the association of bone, joint, and muscle problems in children with a history of allergic disease. Methods: Data were obtained from the 2007 Child and Adolescent Health Measurement Initiative. Univariable and multivariable logistic regression models accounting for the sampling design were used to evaluate associations of bone, joint, and muscle problems with allergic diseases, such as asthma, hay fever, food allergies, and eczema. Associations were summarized with odds ratios (ORs) and 95% confidence intervals (CIs). Results: The survey included 91,642 individuals aged 0 to 17 years. Multivariable modeling found statistically significant associations between the number of allergic diseases and bone, joint, and muscle problems (1 allergic disease: adjusted OR, 1.28; 95% CI, 1.04-1.56; P = .02; 2 allergic diseases: adjusted OR, 2.55; 95% CI, 1.92-3.39; P < .001; 3 allergic diseases: adjusted OR, 2.70; 95% CI, 1.88-3.86; P < .001; and 4 allergic diseases: adjusted OR, 4.35; 95% CI, 2.46-7.69; P < .001). Severe eczema (but not mild eczema) was associated with bone, joint, and muscle problems (adjusted OR, 2.81; 95% CI, 1.64-4.81; P < .001) and with bone problems (adjusted OR, 6.08; 95% CI, 1.94-19.12; P = .002). Conclusion: Self-reported allergic diseases in children were associated with bone, joint, and muscle problems, and associations strengthened with allergic disease severity and number of allergic diseases. Severe eczema may be associated with bone problems in children. Bone, joint, and muscle problems must be considered in children with severe allergic disease, and prospective studies are necessary to define this association.

Original languageEnglish (US)
JournalAnnals of Allergy, Asthma and Immunology
DOIs
StateAccepted/In press - 2017

Fingerprint

Musculoskeletal Diseases
Odds Ratio
Population
Confidence Intervals
Bone and Bones
Eczema
Joints
Muscles
Logistic Models
Seasonal Allergic Rhinitis
Food Hypersensitivity
Joint Diseases
Bone Diseases
Asthma

ASJC Scopus subject areas

  • Immunology and Allergy
  • Pulmonary and Respiratory Medicine

Cite this

Associations of self-reported allergic diseases and musculoskeletal problems in children. A US population-based study. / Barrick, Benjamin J.; Jalan, Somya; Tollefson, Megha M; Milbrandt, Todd A.; Larson, A. Noelle; Rank, Matthew A; Lohse, Christine M.; Davis, Dawn Marie R.

In: Annals of Allergy, Asthma and Immunology, 2017.

Research output: Contribution to journalArticle

Barrick, Benjamin J. ; Jalan, Somya ; Tollefson, Megha M ; Milbrandt, Todd A. ; Larson, A. Noelle ; Rank, Matthew A ; Lohse, Christine M. ; Davis, Dawn Marie R. / Associations of self-reported allergic diseases and musculoskeletal problems in children. A US population-based study. In: Annals of Allergy, Asthma and Immunology. 2017.
@article{4a9cabde881d438c954b52841bb69e64,
title = "Associations of self-reported allergic diseases and musculoskeletal problems in children. A US population-based study",
abstract = "Background: Previous studies have found increased rates of musculoskeletal problems in adults with allergic disease, but whether this association holds true for children is unknown. Objective: To investigate the association of bone, joint, and muscle problems in children with a history of allergic disease. Methods: Data were obtained from the 2007 Child and Adolescent Health Measurement Initiative. Univariable and multivariable logistic regression models accounting for the sampling design were used to evaluate associations of bone, joint, and muscle problems with allergic diseases, such as asthma, hay fever, food allergies, and eczema. Associations were summarized with odds ratios (ORs) and 95{\%} confidence intervals (CIs). Results: The survey included 91,642 individuals aged 0 to 17 years. Multivariable modeling found statistically significant associations between the number of allergic diseases and bone, joint, and muscle problems (1 allergic disease: adjusted OR, 1.28; 95{\%} CI, 1.04-1.56; P = .02; 2 allergic diseases: adjusted OR, 2.55; 95{\%} CI, 1.92-3.39; P < .001; 3 allergic diseases: adjusted OR, 2.70; 95{\%} CI, 1.88-3.86; P < .001; and 4 allergic diseases: adjusted OR, 4.35; 95{\%} CI, 2.46-7.69; P < .001). Severe eczema (but not mild eczema) was associated with bone, joint, and muscle problems (adjusted OR, 2.81; 95{\%} CI, 1.64-4.81; P < .001) and with bone problems (adjusted OR, 6.08; 95{\%} CI, 1.94-19.12; P = .002). Conclusion: Self-reported allergic diseases in children were associated with bone, joint, and muscle problems, and associations strengthened with allergic disease severity and number of allergic diseases. Severe eczema may be associated with bone problems in children. Bone, joint, and muscle problems must be considered in children with severe allergic disease, and prospective studies are necessary to define this association.",
author = "Barrick, {Benjamin J.} and Somya Jalan and Tollefson, {Megha M} and Milbrandt, {Todd A.} and Larson, {A. Noelle} and Rank, {Matthew A} and Lohse, {Christine M.} and Davis, {Dawn Marie R.}",
year = "2017",
doi = "10.1016/j.anai.2017.06.002",
language = "English (US)",
journal = "Annals of Allergy, Asthma and Immunology",
issn = "1081-1206",
publisher = "American College of Allergy, Asthma and Immunology",

}

TY - JOUR

T1 - Associations of self-reported allergic diseases and musculoskeletal problems in children. A US population-based study

AU - Barrick, Benjamin J.

AU - Jalan, Somya

AU - Tollefson, Megha M

AU - Milbrandt, Todd A.

AU - Larson, A. Noelle

AU - Rank, Matthew A

AU - Lohse, Christine M.

AU - Davis, Dawn Marie R.

PY - 2017

Y1 - 2017

N2 - Background: Previous studies have found increased rates of musculoskeletal problems in adults with allergic disease, but whether this association holds true for children is unknown. Objective: To investigate the association of bone, joint, and muscle problems in children with a history of allergic disease. Methods: Data were obtained from the 2007 Child and Adolescent Health Measurement Initiative. Univariable and multivariable logistic regression models accounting for the sampling design were used to evaluate associations of bone, joint, and muscle problems with allergic diseases, such as asthma, hay fever, food allergies, and eczema. Associations were summarized with odds ratios (ORs) and 95% confidence intervals (CIs). Results: The survey included 91,642 individuals aged 0 to 17 years. Multivariable modeling found statistically significant associations between the number of allergic diseases and bone, joint, and muscle problems (1 allergic disease: adjusted OR, 1.28; 95% CI, 1.04-1.56; P = .02; 2 allergic diseases: adjusted OR, 2.55; 95% CI, 1.92-3.39; P < .001; 3 allergic diseases: adjusted OR, 2.70; 95% CI, 1.88-3.86; P < .001; and 4 allergic diseases: adjusted OR, 4.35; 95% CI, 2.46-7.69; P < .001). Severe eczema (but not mild eczema) was associated with bone, joint, and muscle problems (adjusted OR, 2.81; 95% CI, 1.64-4.81; P < .001) and with bone problems (adjusted OR, 6.08; 95% CI, 1.94-19.12; P = .002). Conclusion: Self-reported allergic diseases in children were associated with bone, joint, and muscle problems, and associations strengthened with allergic disease severity and number of allergic diseases. Severe eczema may be associated with bone problems in children. Bone, joint, and muscle problems must be considered in children with severe allergic disease, and prospective studies are necessary to define this association.

AB - Background: Previous studies have found increased rates of musculoskeletal problems in adults with allergic disease, but whether this association holds true for children is unknown. Objective: To investigate the association of bone, joint, and muscle problems in children with a history of allergic disease. Methods: Data were obtained from the 2007 Child and Adolescent Health Measurement Initiative. Univariable and multivariable logistic regression models accounting for the sampling design were used to evaluate associations of bone, joint, and muscle problems with allergic diseases, such as asthma, hay fever, food allergies, and eczema. Associations were summarized with odds ratios (ORs) and 95% confidence intervals (CIs). Results: The survey included 91,642 individuals aged 0 to 17 years. Multivariable modeling found statistically significant associations between the number of allergic diseases and bone, joint, and muscle problems (1 allergic disease: adjusted OR, 1.28; 95% CI, 1.04-1.56; P = .02; 2 allergic diseases: adjusted OR, 2.55; 95% CI, 1.92-3.39; P < .001; 3 allergic diseases: adjusted OR, 2.70; 95% CI, 1.88-3.86; P < .001; and 4 allergic diseases: adjusted OR, 4.35; 95% CI, 2.46-7.69; P < .001). Severe eczema (but not mild eczema) was associated with bone, joint, and muscle problems (adjusted OR, 2.81; 95% CI, 1.64-4.81; P < .001) and with bone problems (adjusted OR, 6.08; 95% CI, 1.94-19.12; P = .002). Conclusion: Self-reported allergic diseases in children were associated with bone, joint, and muscle problems, and associations strengthened with allergic disease severity and number of allergic diseases. Severe eczema may be associated with bone problems in children. Bone, joint, and muscle problems must be considered in children with severe allergic disease, and prospective studies are necessary to define this association.

UR - http://www.scopus.com/inward/record.url?scp=85021363299&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85021363299&partnerID=8YFLogxK

U2 - 10.1016/j.anai.2017.06.002

DO - 10.1016/j.anai.2017.06.002

M3 - Article

C2 - 28668547

AN - SCOPUS:85021363299

JO - Annals of Allergy, Asthma and Immunology

JF - Annals of Allergy, Asthma and Immunology

SN - 1081-1206

ER -