Associations of Non-Hodgkin Lymphoma (NHL) risk with autoimmune conditions according to putative NHL loci

Sophia S. Wang; Claire M. Vajdic; Martha S. Linet; Susan L. Slager; Jenna Voutsinas; Alexandra Nieters; Silvia De Sanjose; Wendy Cozen; Graciela S. Alarcón; Otoniel Martinez-Maza; Elizabeth E. Brown; Paige M. Bracci; Tracy Lightfoot; Jennifer Turner; Henrik Hjalgrim; John J. Spinelli; Tongzhang Zheng; Lindsay M. Morton; Brenda M. Birmann; Christopher R. Flowers; Ora Paltiel; Nikolaus Becker; Elizabeth A. Holly; Eleanor Kane; Dennis Weisenburger; Marc Maynadie; Pierluigi Cocco; Lenka Foretova; Anthony Staines; Scott Davis; Richard Severson; James R. Cerhan; Elizabeth C. Breen; Qing Lan; Angela Brooks-Wilson; Anneclaire J. De Roos; Martyn T. Smith; Eve Roman; Paolo Boffetta; Anne Kricker; Yawei Zhang; Christine Skibola; Stephen J. Chanock; Nathaniel Rothman; Yolanda Benavente; Patricia Hartge; Karin E. Smedby

doi:10.1093/aje/kwu290

Associations of Non-Hodgkin Lymphoma (NHL) risk with autoimmune conditions according to putative NHL loci

Sophia S. Wang, Claire M. Vajdic, Martha S. Linet, Susan L. Slager, Jenna Voutsinas, Alexandra Nieters, Silvia De Sanjose, Wendy Cozen, Graciela S. Alarcón, Otoniel Martinez-Maza, Elizabeth E. Brown, Paige M. Bracci, Tracy Lightfoot, Jennifer Turner, Henrik Hjalgrim, John J. Spinelli, Tongzhang Zheng, Lindsay M. Morton, Brenda M. Birmann, Christopher R. FlowersOra Paltiel, Nikolaus Becker, Elizabeth A. Holly, Eleanor Kane, Dennis Weisenburger, Marc Maynadie, Pierluigi Cocco, Lenka Foretova, Anthony Staines, Scott Davis, Richard Severson, James R. Cerhan, Elizabeth C. Breen, Qing Lan, Angela Brooks-Wilson, Anneclaire J. De Roos, Martyn T. Smith, Eve Roman, Paolo Boffetta, Anne Kricker, Yawei Zhang, Christine Skibola, Stephen J. Chanock, Nathaniel Rothman, Yolanda Benavente, Patricia Hartge, Karin E. Smedby

Quantitative Health Sciences

Research output: Contribution to journal › Article › peer-review

37 Scopus citations

Abstract

Autoimmune conditions and immune system-related genetic variations are associated with risk of non-Hodgkin lymphoma (NHL). In a pooled analysis of 8,692 NHL cases and 9,260 controls from 14 studies (1988-2007) within the International Lymphoma Epidemiology Consortium, we evaluated the interaction between immune system genetic variants and autoimmune conditions in NHL risk. We evaluated the immunity-related single nucleotide polymorphisms rs1800629 (tumor necrosis factor gene (TNF) G308A), rs1800890 (interleukin-10 gene (IL10) T3575A), rs6457327 (human leukocyte antigen gene (HLA) class I), rs10484561 (HLA class II), and rs2647012 (HLA class II)) and categorized autoimmune conditions as primarily mediated by B-cell or T-cell responses. We constructed unconditional logistic regression models to measure associations between autoimmune conditions and NHL with stratification by genotype. Autoimmune conditions mediated by B-cell responses were associated with increased NHL risk, specifically diffuse large B-cell lymphoma (odds ratio (OR) = 3.11, 95% confidence interval (CI): 2.25, 4.30) and marginal zone lymphoma (OR = 5.80, 95% CI: 3.82, 8.80); those mediated by T-cell responses were associated with peripheral T-cell lymphoma (OR = 2.14, 95% CI: 1.35, 3.38). In the presence of the rs1800629 AG/AA genotype, B-cell-mediated autoimmune conditions increased NHL risk (OR = 3.27, 95% CI: 2.07, 5.16; P-interaction = 0.03) in comparison with the GG genotype (OR = 1.82, 95% CI: 1.31, 2.53). This interaction was consistent across major B-cell NHL subtypes, including marginal zone lymphoma (P-interaction = 0.02) and follicular lymphoma (P-interaction = 0.04).

Original language	English (US)
Pages (from-to)	406-421
Number of pages	16
Journal	American journal of epidemiology
Volume	181
Issue number	6
DOIs	https://doi.org/10.1093/aje/kwu290
State	Published - Dec 8 2015

Keywords

autoimmune conditions
environment
genetics
human leukocyte antigen
interaction
lymphoma, non-Hodgkin
tumor necrosis factor

ASJC Scopus subject areas

General Medicine

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10.1093/aje/kwu290

Cite this

Wang, S. S., Vajdic, C. M., Linet, M. S., Slager, S. L., Voutsinas, J., Nieters, A., De Sanjose, S., Cozen, W., Alarcón, G. S., Martinez-Maza, O., Brown, E. E., Bracci, P. M., Lightfoot, T., Turner, J., Hjalgrim, H., Spinelli, J. J., Zheng, T., Morton, L. M., Birmann, B. M., ... Smedby, K. E. (2015). Associations of Non-Hodgkin Lymphoma (NHL) risk with autoimmune conditions according to putative NHL loci. American journal of epidemiology, 181(6), 406-421. https://doi.org/10.1093/aje/kwu290

Wang, SS, Vajdic, CM, Linet, MS, Slager, SL, Voutsinas, J, Nieters, A, De Sanjose, S, Cozen, W, Alarcón, GS, Martinez-Maza, O, Brown, EE, Bracci, PM, Lightfoot, T, Turner, J, Hjalgrim, H, Spinelli, JJ, Zheng, T, Morton, LM, Birmann, BM, Flowers, CR, Paltiel, O, Becker, N, Holly, EA, Kane, E, Weisenburger, D, Maynadie, M, Cocco, P, Foretova, L, Staines, A, Davis, S, Severson, R, Cerhan, JR, Breen, EC, Lan, Q, Brooks-Wilson, A, De Roos, AJ, Smith, MT, Roman, E, Boffetta, P, Kricker, A, Zhang, Y, Skibola, C, Chanock, SJ, Rothman, N, Benavente, Y, Hartge, P & Smedby, KE 2015, 'Associations of Non-Hodgkin Lymphoma (NHL) risk with autoimmune conditions according to putative NHL loci', American journal of epidemiology, vol. 181, no. 6, pp. 406-421. https://doi.org/10.1093/aje/kwu290

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title = "Associations of Non-Hodgkin Lymphoma (NHL) risk with autoimmune conditions according to putative NHL loci",

abstract = "Autoimmune conditions and immune system-related genetic variations are associated with risk of non-Hodgkin lymphoma (NHL). In a pooled analysis of 8,692 NHL cases and 9,260 controls from 14 studies (1988-2007) within the International Lymphoma Epidemiology Consortium, we evaluated the interaction between immune system genetic variants and autoimmune conditions in NHL risk. We evaluated the immunity-related single nucleotide polymorphisms rs1800629 (tumor necrosis factor gene (TNF) G308A), rs1800890 (interleukin-10 gene (IL10) T3575A), rs6457327 (human leukocyte antigen gene (HLA) class I), rs10484561 (HLA class II), and rs2647012 (HLA class II)) and categorized autoimmune conditions as primarily mediated by B-cell or T-cell responses. We constructed unconditional logistic regression models to measure associations between autoimmune conditions and NHL with stratification by genotype. Autoimmune conditions mediated by B-cell responses were associated with increased NHL risk, specifically diffuse large B-cell lymphoma (odds ratio (OR) = 3.11, 95% confidence interval (CI): 2.25, 4.30) and marginal zone lymphoma (OR = 5.80, 95% CI: 3.82, 8.80); those mediated by T-cell responses were associated with peripheral T-cell lymphoma (OR = 2.14, 95% CI: 1.35, 3.38). In the presence of the rs1800629 AG/AA genotype, B-cell-mediated autoimmune conditions increased NHL risk (OR = 3.27, 95% CI: 2.07, 5.16; P-interaction = 0.03) in comparison with the GG genotype (OR = 1.82, 95% CI: 1.31, 2.53). This interaction was consistent across major B-cell NHL subtypes, including marginal zone lymphoma (P-interaction = 0.02) and follicular lymphoma (P-interaction = 0.04).",

keywords = "autoimmune conditions, environment, genetics, human leukocyte antigen, interaction, lymphoma, non-Hodgkin, tumor necrosis factor",

author = "Wang, {Sophia S.} and Vajdic, {Claire M.} and Linet, {Martha S.} and Slager, {Susan L.} and Jenna Voutsinas and Alexandra Nieters and {De Sanjose}, Silvia and Wendy Cozen and Alarc{\'o}n, {Graciela S.} and Otoniel Martinez-Maza and Brown, {Elizabeth E.} and Bracci, {Paige M.} and Tracy Lightfoot and Jennifer Turner and Henrik Hjalgrim and Spinelli, {John J.} and Tongzhang Zheng and Morton, {Lindsay M.} and Birmann, {Brenda M.} and Flowers, {Christopher R.} and Ora Paltiel and Nikolaus Becker and Holly, {Elizabeth A.} and Eleanor Kane and Dennis Weisenburger and Marc Maynadie and Pierluigi Cocco and Lenka Foretova and Anthony Staines and Scott Davis and Richard Severson and Cerhan, {James R.} and Breen, {Elizabeth C.} and Qing Lan and Angela Brooks-Wilson and {De Roos}, {Anneclaire J.} and Smith, {Martyn T.} and Eve Roman and Paolo Boffetta and Anne Kricker and Yawei Zhang and Christine Skibola and Chanock, {Stephen J.} and Nathaniel Rothman and Yolanda Benavente and Patricia Hartge and Smedby, {Karin E.}",

note = "Publisher Copyright: {\textcopyright} The Author 2015. Published by Oxford University Press on behalf of the Johns Hopkins Bloomberg School of Public Health.",

year = "2015",

month = dec,

day = "8",

doi = "10.1093/aje/kwu290",

language = "English (US)",

volume = "181",

pages = "406--421",

journal = "American journal of epidemiology",

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T1 - Associations of Non-Hodgkin Lymphoma (NHL) risk with autoimmune conditions according to putative NHL loci

AU - Wang, Sophia S.

AU - Vajdic, Claire M.

AU - Linet, Martha S.

AU - Slager, Susan L.

AU - Voutsinas, Jenna

AU - Nieters, Alexandra

AU - De Sanjose, Silvia

AU - Cozen, Wendy

AU - Alarcón, Graciela S.

AU - Martinez-Maza, Otoniel

AU - Brown, Elizabeth E.

AU - Bracci, Paige M.

AU - Lightfoot, Tracy

AU - Turner, Jennifer

AU - Hjalgrim, Henrik

AU - Spinelli, John J.

AU - Zheng, Tongzhang

AU - Morton, Lindsay M.

AU - Birmann, Brenda M.

AU - Flowers, Christopher R.

AU - Paltiel, Ora

AU - Becker, Nikolaus

AU - Holly, Elizabeth A.

AU - Kane, Eleanor

AU - Weisenburger, Dennis

AU - Maynadie, Marc

AU - Cocco, Pierluigi

AU - Foretova, Lenka

AU - Staines, Anthony

AU - Davis, Scott

AU - Severson, Richard

AU - Cerhan, James R.

AU - Breen, Elizabeth C.

AU - Lan, Qing

AU - Brooks-Wilson, Angela

AU - De Roos, Anneclaire J.

AU - Smith, Martyn T.

AU - Roman, Eve

AU - Boffetta, Paolo

AU - Kricker, Anne

AU - Zhang, Yawei

AU - Skibola, Christine

AU - Chanock, Stephen J.

AU - Rothman, Nathaniel

AU - Benavente, Yolanda

AU - Hartge, Patricia

AU - Smedby, Karin E.

PY - 2015/12/8

Y1 - 2015/12/8

N2 - Autoimmune conditions and immune system-related genetic variations are associated with risk of non-Hodgkin lymphoma (NHL). In a pooled analysis of 8,692 NHL cases and 9,260 controls from 14 studies (1988-2007) within the International Lymphoma Epidemiology Consortium, we evaluated the interaction between immune system genetic variants and autoimmune conditions in NHL risk. We evaluated the immunity-related single nucleotide polymorphisms rs1800629 (tumor necrosis factor gene (TNF) G308A), rs1800890 (interleukin-10 gene (IL10) T3575A), rs6457327 (human leukocyte antigen gene (HLA) class I), rs10484561 (HLA class II), and rs2647012 (HLA class II)) and categorized autoimmune conditions as primarily mediated by B-cell or T-cell responses. We constructed unconditional logistic regression models to measure associations between autoimmune conditions and NHL with stratification by genotype. Autoimmune conditions mediated by B-cell responses were associated with increased NHL risk, specifically diffuse large B-cell lymphoma (odds ratio (OR) = 3.11, 95% confidence interval (CI): 2.25, 4.30) and marginal zone lymphoma (OR = 5.80, 95% CI: 3.82, 8.80); those mediated by T-cell responses were associated with peripheral T-cell lymphoma (OR = 2.14, 95% CI: 1.35, 3.38). In the presence of the rs1800629 AG/AA genotype, B-cell-mediated autoimmune conditions increased NHL risk (OR = 3.27, 95% CI: 2.07, 5.16; P-interaction = 0.03) in comparison with the GG genotype (OR = 1.82, 95% CI: 1.31, 2.53). This interaction was consistent across major B-cell NHL subtypes, including marginal zone lymphoma (P-interaction = 0.02) and follicular lymphoma (P-interaction = 0.04).

AB - Autoimmune conditions and immune system-related genetic variations are associated with risk of non-Hodgkin lymphoma (NHL). In a pooled analysis of 8,692 NHL cases and 9,260 controls from 14 studies (1988-2007) within the International Lymphoma Epidemiology Consortium, we evaluated the interaction between immune system genetic variants and autoimmune conditions in NHL risk. We evaluated the immunity-related single nucleotide polymorphisms rs1800629 (tumor necrosis factor gene (TNF) G308A), rs1800890 (interleukin-10 gene (IL10) T3575A), rs6457327 (human leukocyte antigen gene (HLA) class I), rs10484561 (HLA class II), and rs2647012 (HLA class II)) and categorized autoimmune conditions as primarily mediated by B-cell or T-cell responses. We constructed unconditional logistic regression models to measure associations between autoimmune conditions and NHL with stratification by genotype. Autoimmune conditions mediated by B-cell responses were associated with increased NHL risk, specifically diffuse large B-cell lymphoma (odds ratio (OR) = 3.11, 95% confidence interval (CI): 2.25, 4.30) and marginal zone lymphoma (OR = 5.80, 95% CI: 3.82, 8.80); those mediated by T-cell responses were associated with peripheral T-cell lymphoma (OR = 2.14, 95% CI: 1.35, 3.38). In the presence of the rs1800629 AG/AA genotype, B-cell-mediated autoimmune conditions increased NHL risk (OR = 3.27, 95% CI: 2.07, 5.16; P-interaction = 0.03) in comparison with the GG genotype (OR = 1.82, 95% CI: 1.31, 2.53). This interaction was consistent across major B-cell NHL subtypes, including marginal zone lymphoma (P-interaction = 0.02) and follicular lymphoma (P-interaction = 0.04).

KW - autoimmune conditions

KW - environment

KW - genetics

KW - human leukocyte antigen

KW - interaction

KW - lymphoma, non-Hodgkin

KW - tumor necrosis factor

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Associations of Non-Hodgkin Lymphoma (NHL) risk with autoimmune conditions according to putative NHL loci

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