Associations of Non-Hodgkin Lymphoma (NHL) risk with autoimmune conditions according to putative NHL loci

Sophia S. Wang, Claire M. Vajdic, Martha S. Linet, Susan L Slager, Jenna Voutsinas, Alexandra Nieters, Silvia De Sanjose, Wendy Cozen, Graciela S. Alarcón, Otoniel Martinez-Maza, Elizabeth E. Brown, Paige M. Bracci, Tracy Lightfoot, Jennifer Turner, Henrik Hjalgrim, John J. Spinelli, Tongzhang Zheng, Lindsay M. Morton, Brenda M. Birmann, Christopher R. FlowersOra Paltiel, Nikolaus Becker, Elizabeth A. Holly, Eleanor Kane, Dennis Weisenburger, Marc Maynadie, Pierluigi Cocco, Lenka Foretova, Anthony Staines, Scott Davis, Richard Severson, James R Cerhan, Elizabeth C. Breen, Qing Lan, Angela Brooks-Wilson, Anneclaire J. De Roos, Martyn T. Smith, Eve Roman, Paolo Boffetta, Anne Kricker, Yawei Zhang, Christine Skibola, Stephen J. Chanock, Nathaniel Rothman, Yolanda Benavente, Patricia Hartge, Karin E. Smedby

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Autoimmune conditions and immune system-related genetic variations are associated with risk of non-Hodgkin lymphoma (NHL). In a pooled analysis of 8,692 NHL cases and 9,260 controls from 14 studies (1988-2007) within the International Lymphoma Epidemiology Consortium, we evaluated the interaction between immune system genetic variants and autoimmune conditions in NHL risk. We evaluated the immunity-related single nucleotide polymorphisms rs1800629 (tumor necrosis factor gene (TNF) G308A), rs1800890 (interleukin-10 gene (IL10) T3575A), rs6457327 (human leukocyte antigen gene (HLA) class I), rs10484561 (HLA class II), and rs2647012 (HLA class II)) and categorized autoimmune conditions as primarily mediated by B-cell or T-cell responses. We constructed unconditional logistic regression models to measure associations between autoimmune conditions and NHL with stratification by genotype. Autoimmune conditions mediated by B-cell responses were associated with increased NHL risk, specifically diffuse large B-cell lymphoma (odds ratio (OR) = 3.11, 95% confidence interval (CI): 2.25, 4.30) and marginal zone lymphoma (OR = 5.80, 95% CI: 3.82, 8.80); those mediated by T-cell responses were associated with peripheral T-cell lymphoma (OR = 2.14, 95% CI: 1.35, 3.38). In the presence of the rs1800629 AG/AA genotype, B-cell-mediated autoimmune conditions increased NHL risk (OR = 3.27, 95% CI: 2.07, 5.16; P-interaction = 0.03) in comparison with the GG genotype (OR = 1.82, 95% CI: 1.31, 2.53). This interaction was consistent across major B-cell NHL subtypes, including marginal zone lymphoma (P-interaction = 0.02) and follicular lymphoma (P-interaction = 0.04).

Original languageEnglish (US)
Pages (from-to)406-421
Number of pages16
JournalAmerican Journal of Epidemiology
Volume181
Issue number6
DOIs
StatePublished - Dec 8 2014

Fingerprint

Non-Hodgkin's Lymphoma
Odds Ratio
Confidence Intervals
HLA Antigens
Lymphoma
MHC Class II Genes
B-Lymphocytes
Genotype
Immune System
Logistic Models
Peripheral T-Cell Lymphoma
MHC Class I Genes
T-Lymphocytes
Follicular Lymphoma
Lymphoma, Large B-Cell, Diffuse
B-Cell Lymphoma
Interleukin-10
Genes
Single Nucleotide Polymorphism
Immunity

Keywords

  • autoimmune conditions
  • environment
  • genetics
  • human leukocyte antigen
  • interaction
  • lymphoma, non-Hodgkin
  • tumor necrosis factor

ASJC Scopus subject areas

  • Epidemiology

Cite this

Associations of Non-Hodgkin Lymphoma (NHL) risk with autoimmune conditions according to putative NHL loci. / Wang, Sophia S.; Vajdic, Claire M.; Linet, Martha S.; Slager, Susan L; Voutsinas, Jenna; Nieters, Alexandra; De Sanjose, Silvia; Cozen, Wendy; Alarcón, Graciela S.; Martinez-Maza, Otoniel; Brown, Elizabeth E.; Bracci, Paige M.; Lightfoot, Tracy; Turner, Jennifer; Hjalgrim, Henrik; Spinelli, John J.; Zheng, Tongzhang; Morton, Lindsay M.; Birmann, Brenda M.; Flowers, Christopher R.; Paltiel, Ora; Becker, Nikolaus; Holly, Elizabeth A.; Kane, Eleanor; Weisenburger, Dennis; Maynadie, Marc; Cocco, Pierluigi; Foretova, Lenka; Staines, Anthony; Davis, Scott; Severson, Richard; Cerhan, James R; Breen, Elizabeth C.; Lan, Qing; Brooks-Wilson, Angela; De Roos, Anneclaire J.; Smith, Martyn T.; Roman, Eve; Boffetta, Paolo; Kricker, Anne; Zhang, Yawei; Skibola, Christine; Chanock, Stephen J.; Rothman, Nathaniel; Benavente, Yolanda; Hartge, Patricia; Smedby, Karin E.

In: American Journal of Epidemiology, Vol. 181, No. 6, 08.12.2014, p. 406-421.

Research output: Contribution to journalArticle

Wang, SS, Vajdic, CM, Linet, MS, Slager, SL, Voutsinas, J, Nieters, A, De Sanjose, S, Cozen, W, Alarcón, GS, Martinez-Maza, O, Brown, EE, Bracci, PM, Lightfoot, T, Turner, J, Hjalgrim, H, Spinelli, JJ, Zheng, T, Morton, LM, Birmann, BM, Flowers, CR, Paltiel, O, Becker, N, Holly, EA, Kane, E, Weisenburger, D, Maynadie, M, Cocco, P, Foretova, L, Staines, A, Davis, S, Severson, R, Cerhan, JR, Breen, EC, Lan, Q, Brooks-Wilson, A, De Roos, AJ, Smith, MT, Roman, E, Boffetta, P, Kricker, A, Zhang, Y, Skibola, C, Chanock, SJ, Rothman, N, Benavente, Y, Hartge, P & Smedby, KE 2014, 'Associations of Non-Hodgkin Lymphoma (NHL) risk with autoimmune conditions according to putative NHL loci', American Journal of Epidemiology, vol. 181, no. 6, pp. 406-421. https://doi.org/10.1093/aje/kwu290
Wang, Sophia S. ; Vajdic, Claire M. ; Linet, Martha S. ; Slager, Susan L ; Voutsinas, Jenna ; Nieters, Alexandra ; De Sanjose, Silvia ; Cozen, Wendy ; Alarcón, Graciela S. ; Martinez-Maza, Otoniel ; Brown, Elizabeth E. ; Bracci, Paige M. ; Lightfoot, Tracy ; Turner, Jennifer ; Hjalgrim, Henrik ; Spinelli, John J. ; Zheng, Tongzhang ; Morton, Lindsay M. ; Birmann, Brenda M. ; Flowers, Christopher R. ; Paltiel, Ora ; Becker, Nikolaus ; Holly, Elizabeth A. ; Kane, Eleanor ; Weisenburger, Dennis ; Maynadie, Marc ; Cocco, Pierluigi ; Foretova, Lenka ; Staines, Anthony ; Davis, Scott ; Severson, Richard ; Cerhan, James R ; Breen, Elizabeth C. ; Lan, Qing ; Brooks-Wilson, Angela ; De Roos, Anneclaire J. ; Smith, Martyn T. ; Roman, Eve ; Boffetta, Paolo ; Kricker, Anne ; Zhang, Yawei ; Skibola, Christine ; Chanock, Stephen J. ; Rothman, Nathaniel ; Benavente, Yolanda ; Hartge, Patricia ; Smedby, Karin E. / Associations of Non-Hodgkin Lymphoma (NHL) risk with autoimmune conditions according to putative NHL loci. In: American Journal of Epidemiology. 2014 ; Vol. 181, No. 6. pp. 406-421.
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T1 - Associations of Non-Hodgkin Lymphoma (NHL) risk with autoimmune conditions according to putative NHL loci

AU - Wang, Sophia S.

AU - Vajdic, Claire M.

AU - Linet, Martha S.

AU - Slager, Susan L

AU - Voutsinas, Jenna

AU - Nieters, Alexandra

AU - De Sanjose, Silvia

AU - Cozen, Wendy

AU - Alarcón, Graciela S.

AU - Martinez-Maza, Otoniel

AU - Brown, Elizabeth E.

AU - Bracci, Paige M.

AU - Lightfoot, Tracy

AU - Turner, Jennifer

AU - Hjalgrim, Henrik

AU - Spinelli, John J.

AU - Zheng, Tongzhang

AU - Morton, Lindsay M.

AU - Birmann, Brenda M.

AU - Flowers, Christopher R.

AU - Paltiel, Ora

AU - Becker, Nikolaus

AU - Holly, Elizabeth A.

AU - Kane, Eleanor

AU - Weisenburger, Dennis

AU - Maynadie, Marc

AU - Cocco, Pierluigi

AU - Foretova, Lenka

AU - Staines, Anthony

AU - Davis, Scott

AU - Severson, Richard

AU - Cerhan, James R

AU - Breen, Elizabeth C.

AU - Lan, Qing

AU - Brooks-Wilson, Angela

AU - De Roos, Anneclaire J.

AU - Smith, Martyn T.

AU - Roman, Eve

AU - Boffetta, Paolo

AU - Kricker, Anne

AU - Zhang, Yawei

AU - Skibola, Christine

AU - Chanock, Stephen J.

AU - Rothman, Nathaniel

AU - Benavente, Yolanda

AU - Hartge, Patricia

AU - Smedby, Karin E.

PY - 2014/12/8

Y1 - 2014/12/8

N2 - Autoimmune conditions and immune system-related genetic variations are associated with risk of non-Hodgkin lymphoma (NHL). In a pooled analysis of 8,692 NHL cases and 9,260 controls from 14 studies (1988-2007) within the International Lymphoma Epidemiology Consortium, we evaluated the interaction between immune system genetic variants and autoimmune conditions in NHL risk. We evaluated the immunity-related single nucleotide polymorphisms rs1800629 (tumor necrosis factor gene (TNF) G308A), rs1800890 (interleukin-10 gene (IL10) T3575A), rs6457327 (human leukocyte antigen gene (HLA) class I), rs10484561 (HLA class II), and rs2647012 (HLA class II)) and categorized autoimmune conditions as primarily mediated by B-cell or T-cell responses. We constructed unconditional logistic regression models to measure associations between autoimmune conditions and NHL with stratification by genotype. Autoimmune conditions mediated by B-cell responses were associated with increased NHL risk, specifically diffuse large B-cell lymphoma (odds ratio (OR) = 3.11, 95% confidence interval (CI): 2.25, 4.30) and marginal zone lymphoma (OR = 5.80, 95% CI: 3.82, 8.80); those mediated by T-cell responses were associated with peripheral T-cell lymphoma (OR = 2.14, 95% CI: 1.35, 3.38). In the presence of the rs1800629 AG/AA genotype, B-cell-mediated autoimmune conditions increased NHL risk (OR = 3.27, 95% CI: 2.07, 5.16; P-interaction = 0.03) in comparison with the GG genotype (OR = 1.82, 95% CI: 1.31, 2.53). This interaction was consistent across major B-cell NHL subtypes, including marginal zone lymphoma (P-interaction = 0.02) and follicular lymphoma (P-interaction = 0.04).

AB - Autoimmune conditions and immune system-related genetic variations are associated with risk of non-Hodgkin lymphoma (NHL). In a pooled analysis of 8,692 NHL cases and 9,260 controls from 14 studies (1988-2007) within the International Lymphoma Epidemiology Consortium, we evaluated the interaction between immune system genetic variants and autoimmune conditions in NHL risk. We evaluated the immunity-related single nucleotide polymorphisms rs1800629 (tumor necrosis factor gene (TNF) G308A), rs1800890 (interleukin-10 gene (IL10) T3575A), rs6457327 (human leukocyte antigen gene (HLA) class I), rs10484561 (HLA class II), and rs2647012 (HLA class II)) and categorized autoimmune conditions as primarily mediated by B-cell or T-cell responses. We constructed unconditional logistic regression models to measure associations between autoimmune conditions and NHL with stratification by genotype. Autoimmune conditions mediated by B-cell responses were associated with increased NHL risk, specifically diffuse large B-cell lymphoma (odds ratio (OR) = 3.11, 95% confidence interval (CI): 2.25, 4.30) and marginal zone lymphoma (OR = 5.80, 95% CI: 3.82, 8.80); those mediated by T-cell responses were associated with peripheral T-cell lymphoma (OR = 2.14, 95% CI: 1.35, 3.38). In the presence of the rs1800629 AG/AA genotype, B-cell-mediated autoimmune conditions increased NHL risk (OR = 3.27, 95% CI: 2.07, 5.16; P-interaction = 0.03) in comparison with the GG genotype (OR = 1.82, 95% CI: 1.31, 2.53). This interaction was consistent across major B-cell NHL subtypes, including marginal zone lymphoma (P-interaction = 0.02) and follicular lymphoma (P-interaction = 0.04).

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KW - environment

KW - genetics

KW - human leukocyte antigen

KW - interaction

KW - lymphoma, non-Hodgkin

KW - tumor necrosis factor

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