Associations of high-grade glioma with glioma risk alleles and histories of allergy and smoking

Daniel H Lachance, Ping Yang, Derek R. Johnson, Paul A. Decker, Thomas M. Kollmeyer, Lucie S. McCoy, Terri Rice, Yuanyuan Xiao, Francis Ali-Osman, Frances Wang, Shawn M. Stoddard, Debra J. Sprau, Matthew L. Kosel, John K. Wiencke, Joseph L. Wiemels, Joseph S. Patoka, Faith Davis, Bridget McCarthy, Amanda L. Rynearson, Joel B. WorraBrooke L. Fridley, Brian Patrick O'Neill, Jan Craig Buckner, Dora Il'Yasova, Robert Brian Jenkins, Margaret R. Wrensch

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Abstract

Glioma risk has consistently been inversely associated with allergy history but not with smoking history despite putative biologic plausibility. Data from 855 high-grade glioma cases and 1,160 controls from 4 geographic regions of the United States during 1997-2008 were analyzed for interactions between allergy and smoking histories and inherited variants in 5 established glioma risk regions: 5p15.3 (TERT), 8q24.21 (CCDC26/MLZE), 9p21.3 (CDKN2B), 11q23.3 (PHLDB1/DDX6), and 20q13.3 (RTEL1). The inverse relation between allergy and glioma was stronger among those who did not (odds ratioallergy-glioma = 0.40, 95% confidence interval: 0.28, 0.58) versus those who did (odds ratioallergy-glioma = 0.76, 95% confidence interval: 0.59, 0.97; Pinteraction = 0.02) carry the 9p21.3 risk allele. However, the inverse association with allergy was stronger among those who carried (odds ratioallergy-glioma = 0.44, 95% confidence interval: 0.29, 0.68) versus those who did not carry (odds ratioallergy-glioma = 0.68, 95% confidence interval: 0.54, 0.86) the 20q13.3 glioma risk allele, but this interaction was not statistically significant (P = 0.14). No relation was observed between glioma risk and smoking (odds ratio = 0.92, 95% confidence interval: 0.77, 1.10; P = 0.37), and there were no interactions for glioma risk of smoking history with any of the risk alleles. The authors' observations are consistent with a recent report that the inherited glioma risk variants in chromosome regions 9p21.3 and 20q13.3 may modify the inverse association of allergy and glioma.

Original languageEnglish (US)
Pages (from-to)574-581
Number of pages8
JournalAmerican Journal of Epidemiology
Volume174
Issue number5
DOIs
StatePublished - Sep 1 2011

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Glioma
Hypersensitivity
Smoking
Alleles
Confidence Intervals
History
Chromosomes
Odds Ratio

Keywords

  • allergy and immunology
  • glioma
  • hypersensitivity
  • polymorphism, single nucleotide

ASJC Scopus subject areas

  • Epidemiology

Cite this

Associations of high-grade glioma with glioma risk alleles and histories of allergy and smoking. / Lachance, Daniel H; Yang, Ping; Johnson, Derek R.; Decker, Paul A.; Kollmeyer, Thomas M.; McCoy, Lucie S.; Rice, Terri; Xiao, Yuanyuan; Ali-Osman, Francis; Wang, Frances; Stoddard, Shawn M.; Sprau, Debra J.; Kosel, Matthew L.; Wiencke, John K.; Wiemels, Joseph L.; Patoka, Joseph S.; Davis, Faith; McCarthy, Bridget; Rynearson, Amanda L.; Worra, Joel B.; Fridley, Brooke L.; O'Neill, Brian Patrick; Buckner, Jan Craig; Il'Yasova, Dora; Jenkins, Robert Brian; Wrensch, Margaret R.

In: American Journal of Epidemiology, Vol. 174, No. 5, 01.09.2011, p. 574-581.

Research output: Contribution to journalArticle

Lachance, DH, Yang, P, Johnson, DR, Decker, PA, Kollmeyer, TM, McCoy, LS, Rice, T, Xiao, Y, Ali-Osman, F, Wang, F, Stoddard, SM, Sprau, DJ, Kosel, ML, Wiencke, JK, Wiemels, JL, Patoka, JS, Davis, F, McCarthy, B, Rynearson, AL, Worra, JB, Fridley, BL, O'Neill, BP, Buckner, JC, Il'Yasova, D, Jenkins, RB & Wrensch, MR 2011, 'Associations of high-grade glioma with glioma risk alleles and histories of allergy and smoking', American Journal of Epidemiology, vol. 174, no. 5, pp. 574-581. https://doi.org/10.1093/aje/kwr124
Lachance, Daniel H ; Yang, Ping ; Johnson, Derek R. ; Decker, Paul A. ; Kollmeyer, Thomas M. ; McCoy, Lucie S. ; Rice, Terri ; Xiao, Yuanyuan ; Ali-Osman, Francis ; Wang, Frances ; Stoddard, Shawn M. ; Sprau, Debra J. ; Kosel, Matthew L. ; Wiencke, John K. ; Wiemels, Joseph L. ; Patoka, Joseph S. ; Davis, Faith ; McCarthy, Bridget ; Rynearson, Amanda L. ; Worra, Joel B. ; Fridley, Brooke L. ; O'Neill, Brian Patrick ; Buckner, Jan Craig ; Il'Yasova, Dora ; Jenkins, Robert Brian ; Wrensch, Margaret R. / Associations of high-grade glioma with glioma risk alleles and histories of allergy and smoking. In: American Journal of Epidemiology. 2011 ; Vol. 174, No. 5. pp. 574-581.
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AU - Lachance, Daniel H

AU - Yang, Ping

AU - Johnson, Derek R.

AU - Decker, Paul A.

AU - Kollmeyer, Thomas M.

AU - McCoy, Lucie S.

AU - Rice, Terri

AU - Xiao, Yuanyuan

AU - Ali-Osman, Francis

AU - Wang, Frances

AU - Stoddard, Shawn M.

AU - Sprau, Debra J.

AU - Kosel, Matthew L.

AU - Wiencke, John K.

AU - Wiemels, Joseph L.

AU - Patoka, Joseph S.

AU - Davis, Faith

AU - McCarthy, Bridget

AU - Rynearson, Amanda L.

AU - Worra, Joel B.

AU - Fridley, Brooke L.

AU - O'Neill, Brian Patrick

AU - Buckner, Jan Craig

AU - Il'Yasova, Dora

AU - Jenkins, Robert Brian

AU - Wrensch, Margaret R.

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N2 - Glioma risk has consistently been inversely associated with allergy history but not with smoking history despite putative biologic plausibility. Data from 855 high-grade glioma cases and 1,160 controls from 4 geographic regions of the United States during 1997-2008 were analyzed for interactions between allergy and smoking histories and inherited variants in 5 established glioma risk regions: 5p15.3 (TERT), 8q24.21 (CCDC26/MLZE), 9p21.3 (CDKN2B), 11q23.3 (PHLDB1/DDX6), and 20q13.3 (RTEL1). The inverse relation between allergy and glioma was stronger among those who did not (odds ratioallergy-glioma = 0.40, 95% confidence interval: 0.28, 0.58) versus those who did (odds ratioallergy-glioma = 0.76, 95% confidence interval: 0.59, 0.97; Pinteraction = 0.02) carry the 9p21.3 risk allele. However, the inverse association with allergy was stronger among those who carried (odds ratioallergy-glioma = 0.44, 95% confidence interval: 0.29, 0.68) versus those who did not carry (odds ratioallergy-glioma = 0.68, 95% confidence interval: 0.54, 0.86) the 20q13.3 glioma risk allele, but this interaction was not statistically significant (P = 0.14). No relation was observed between glioma risk and smoking (odds ratio = 0.92, 95% confidence interval: 0.77, 1.10; P = 0.37), and there were no interactions for glioma risk of smoking history with any of the risk alleles. The authors' observations are consistent with a recent report that the inherited glioma risk variants in chromosome regions 9p21.3 and 20q13.3 may modify the inverse association of allergy and glioma.

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