TY - JOUR
T1 - Associations of high-grade glioma with glioma risk alleles and histories of allergy and smoking
AU - Lachance, Daniel H.
AU - Yang, Ping
AU - Johnson, Derek R.
AU - Decker, Paul A.
AU - Kollmeyer, Thomas M.
AU - McCoy, Lucie S.
AU - Rice, Terri
AU - Xiao, Yuanyuan
AU - Ali-Osman, Francis
AU - Wang, Frances
AU - Stoddard, Shawn M.
AU - Sprau, Debra J.
AU - Kosel, Matthew L.
AU - Wiencke, John K.
AU - Wiemels, Joseph L.
AU - Patoka, Joseph S.
AU - Davis, Faith
AU - McCarthy, Bridget
AU - Rynearson, Amanda L.
AU - Worra, Joel B.
AU - Fridley, Brooke L.
AU - O'Neill, Brian Patrick
AU - Buckner, Jan C.
AU - Il'Yasova, Dora
AU - Jenkins, Robert B.
AU - Wrensch, Margaret R.
PY - 2011/9/1
Y1 - 2011/9/1
N2 - Glioma risk has consistently been inversely associated with allergy history but not with smoking history despite putative biologic plausibility. Data from 855 high-grade glioma cases and 1,160 controls from 4 geographic regions of the United States during 1997-2008 were analyzed for interactions between allergy and smoking histories and inherited variants in 5 established glioma risk regions: 5p15.3 (TERT), 8q24.21 (CCDC26/MLZE), 9p21.3 (CDKN2B), 11q23.3 (PHLDB1/DDX6), and 20q13.3 (RTEL1). The inverse relation between allergy and glioma was stronger among those who did not (odds ratioallergy-glioma = 0.40, 95% confidence interval: 0.28, 0.58) versus those who did (odds ratioallergy-glioma = 0.76, 95% confidence interval: 0.59, 0.97; Pinteraction = 0.02) carry the 9p21.3 risk allele. However, the inverse association with allergy was stronger among those who carried (odds ratioallergy-glioma = 0.44, 95% confidence interval: 0.29, 0.68) versus those who did not carry (odds ratioallergy-glioma = 0.68, 95% confidence interval: 0.54, 0.86) the 20q13.3 glioma risk allele, but this interaction was not statistically significant (P = 0.14). No relation was observed between glioma risk and smoking (odds ratio = 0.92, 95% confidence interval: 0.77, 1.10; P = 0.37), and there were no interactions for glioma risk of smoking history with any of the risk alleles. The authors' observations are consistent with a recent report that the inherited glioma risk variants in chromosome regions 9p21.3 and 20q13.3 may modify the inverse association of allergy and glioma.
AB - Glioma risk has consistently been inversely associated with allergy history but not with smoking history despite putative biologic plausibility. Data from 855 high-grade glioma cases and 1,160 controls from 4 geographic regions of the United States during 1997-2008 were analyzed for interactions between allergy and smoking histories and inherited variants in 5 established glioma risk regions: 5p15.3 (TERT), 8q24.21 (CCDC26/MLZE), 9p21.3 (CDKN2B), 11q23.3 (PHLDB1/DDX6), and 20q13.3 (RTEL1). The inverse relation between allergy and glioma was stronger among those who did not (odds ratioallergy-glioma = 0.40, 95% confidence interval: 0.28, 0.58) versus those who did (odds ratioallergy-glioma = 0.76, 95% confidence interval: 0.59, 0.97; Pinteraction = 0.02) carry the 9p21.3 risk allele. However, the inverse association with allergy was stronger among those who carried (odds ratioallergy-glioma = 0.44, 95% confidence interval: 0.29, 0.68) versus those who did not carry (odds ratioallergy-glioma = 0.68, 95% confidence interval: 0.54, 0.86) the 20q13.3 glioma risk allele, but this interaction was not statistically significant (P = 0.14). No relation was observed between glioma risk and smoking (odds ratio = 0.92, 95% confidence interval: 0.77, 1.10; P = 0.37), and there were no interactions for glioma risk of smoking history with any of the risk alleles. The authors' observations are consistent with a recent report that the inherited glioma risk variants in chromosome regions 9p21.3 and 20q13.3 may modify the inverse association of allergy and glioma.
KW - allergy and immunology
KW - glioma
KW - hypersensitivity
KW - polymorphism, single nucleotide
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U2 - 10.1093/aje/kwr124
DO - 10.1093/aje/kwr124
M3 - Article
C2 - 21742680
AN - SCOPUS:80052200954
SN - 0002-9262
VL - 174
SP - 574
EP - 581
JO - American journal of epidemiology
JF - American journal of epidemiology
IS - 5
ER -