Associations between self-reported diet during treatment and chemotherapy-induced peripheral neuropathy in a cooperative group trial (S0221)

Jennifer M. Mongiovi, Gary R. Zirpoli, Rikki Cannioto, Lara E. Sucheston-Campbell, Dawn L. Hershman, Joseph M. Unger, Halle C.F. Moore, James A. Stewart, Claudine Isaacs, Timothy James Hobday, Muhammad Salim, Gabriel N. Hortobagyi, Julie R. Gralow, G. Thomas Budd, Kathy S. Albain, Christine B. Ambrosone, Susan E. McCann

Research output: Contribution to journalArticle

Abstract

Background: The pathophysiology of chemotherapy-induced peripheral neuropathy (CIPN) is not well understood. Currently, dose reduction is the only recommendation for alleviating symptoms, often leading to premature treatment cessation. The primary aim of this analysis was to determine the association between components of diet during taxane treatment for breast cancer and change in CIPN symptoms over treatment. Methods: Women with stage II or III invasive breast cancer were enrolled into an ancillary study to the North American Breast Cancer Intergroup phase III trial (S0221) led by the Southwest Oncology Group (SWOG). Questionnaires including a food frequency questionnaire and the Functional Assessment of Cancer Treatment Gynecologic Oncology Group - Neurotoxicity were administered to assess diet and neuropathic conditions at baseline and during chemotherapy. Ordinal regression was used to estimate odds ratios (ORs) for associations between various food groups and change in neuropathy score (< 10%, 10-30%, > 30%) (n = 900). Results: The odds of worse neuropathy decreased by 21% for each increase in tertile of grain consumption (OR = 0.79, 95% CI 0.66-0.94, p = 0.009). We also observed a nominal 19% increase with higher consumption of citrus fruits (OR = 1.19, 95% CI 1.01-1.40, p = 0.05). Conclusions: Distinguishing between those who experienced a moderate and a severe change in neuropathy, we found that citrus fruit and grain consumption may play a role in the severity of symptoms. Since there are no existing dietary recommendations for the management of CIPN, further research is needed to investigate whether there may be certain foods that could worsen or alleviate neuropathy symptoms associated with treatment for breast cancer. Trial registration: ClinicalTrials.gov, NCT03413761. Registered retrospectively on 29 January 2018.

Original languageEnglish (US)
Article number1077
JournalBreast Cancer Research
Volume20
Issue number1
DOIs
StatePublished - Nov 28 2018

Fingerprint

Peripheral Nervous System Diseases
Breast Neoplasms
Diet
Drug Therapy
Citrus
Odds Ratio
Food
Withholding Treatment
Therapeutics
Research
Neoplasms
Surveys and Questionnaires

Keywords

  • Breast cancer
  • Chemotherapy-induced peripheral neuropathy
  • Diet
  • Peripheral nervous system diseases
  • Taxane

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Mongiovi, J. M., Zirpoli, G. R., Cannioto, R., Sucheston-Campbell, L. E., Hershman, D. L., Unger, J. M., ... McCann, S. E. (2018). Associations between self-reported diet during treatment and chemotherapy-induced peripheral neuropathy in a cooperative group trial (S0221). Breast Cancer Research, 20(1), [1077]. https://doi.org/10.1186/s13058-018-1077-9

Associations between self-reported diet during treatment and chemotherapy-induced peripheral neuropathy in a cooperative group trial (S0221). / Mongiovi, Jennifer M.; Zirpoli, Gary R.; Cannioto, Rikki; Sucheston-Campbell, Lara E.; Hershman, Dawn L.; Unger, Joseph M.; Moore, Halle C.F.; Stewart, James A.; Isaacs, Claudine; Hobday, Timothy James; Salim, Muhammad; Hortobagyi, Gabriel N.; Gralow, Julie R.; Thomas Budd, G.; Albain, Kathy S.; Ambrosone, Christine B.; McCann, Susan E.

In: Breast Cancer Research, Vol. 20, No. 1, 1077, 28.11.2018.

Research output: Contribution to journalArticle

Mongiovi, JM, Zirpoli, GR, Cannioto, R, Sucheston-Campbell, LE, Hershman, DL, Unger, JM, Moore, HCF, Stewart, JA, Isaacs, C, Hobday, TJ, Salim, M, Hortobagyi, GN, Gralow, JR, Thomas Budd, G, Albain, KS, Ambrosone, CB & McCann, SE 2018, 'Associations between self-reported diet during treatment and chemotherapy-induced peripheral neuropathy in a cooperative group trial (S0221)', Breast Cancer Research, vol. 20, no. 1, 1077. https://doi.org/10.1186/s13058-018-1077-9
Mongiovi, Jennifer M. ; Zirpoli, Gary R. ; Cannioto, Rikki ; Sucheston-Campbell, Lara E. ; Hershman, Dawn L. ; Unger, Joseph M. ; Moore, Halle C.F. ; Stewart, James A. ; Isaacs, Claudine ; Hobday, Timothy James ; Salim, Muhammad ; Hortobagyi, Gabriel N. ; Gralow, Julie R. ; Thomas Budd, G. ; Albain, Kathy S. ; Ambrosone, Christine B. ; McCann, Susan E. / Associations between self-reported diet during treatment and chemotherapy-induced peripheral neuropathy in a cooperative group trial (S0221). In: Breast Cancer Research. 2018 ; Vol. 20, No. 1.
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abstract = "Background: The pathophysiology of chemotherapy-induced peripheral neuropathy (CIPN) is not well understood. Currently, dose reduction is the only recommendation for alleviating symptoms, often leading to premature treatment cessation. The primary aim of this analysis was to determine the association between components of diet during taxane treatment for breast cancer and change in CIPN symptoms over treatment. Methods: Women with stage II or III invasive breast cancer were enrolled into an ancillary study to the North American Breast Cancer Intergroup phase III trial (S0221) led by the Southwest Oncology Group (SWOG). Questionnaires including a food frequency questionnaire and the Functional Assessment of Cancer Treatment Gynecologic Oncology Group - Neurotoxicity were administered to assess diet and neuropathic conditions at baseline and during chemotherapy. Ordinal regression was used to estimate odds ratios (ORs) for associations between various food groups and change in neuropathy score (< 10{\%}, 10-30{\%}, > 30{\%}) (n = 900). Results: The odds of worse neuropathy decreased by 21{\%} for each increase in tertile of grain consumption (OR = 0.79, 95{\%} CI 0.66-0.94, p = 0.009). We also observed a nominal 19{\%} increase with higher consumption of citrus fruits (OR = 1.19, 95{\%} CI 1.01-1.40, p = 0.05). Conclusions: Distinguishing between those who experienced a moderate and a severe change in neuropathy, we found that citrus fruit and grain consumption may play a role in the severity of symptoms. Since there are no existing dietary recommendations for the management of CIPN, further research is needed to investigate whether there may be certain foods that could worsen or alleviate neuropathy symptoms associated with treatment for breast cancer. Trial registration: ClinicalTrials.gov, NCT03413761. Registered retrospectively on 29 January 2018.",
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T1 - Associations between self-reported diet during treatment and chemotherapy-induced peripheral neuropathy in a cooperative group trial (S0221)

AU - Mongiovi, Jennifer M.

AU - Zirpoli, Gary R.

AU - Cannioto, Rikki

AU - Sucheston-Campbell, Lara E.

AU - Hershman, Dawn L.

AU - Unger, Joseph M.

AU - Moore, Halle C.F.

AU - Stewart, James A.

AU - Isaacs, Claudine

AU - Hobday, Timothy James

AU - Salim, Muhammad

AU - Hortobagyi, Gabriel N.

AU - Gralow, Julie R.

AU - Thomas Budd, G.

AU - Albain, Kathy S.

AU - Ambrosone, Christine B.

AU - McCann, Susan E.

PY - 2018/11/28

Y1 - 2018/11/28

N2 - Background: The pathophysiology of chemotherapy-induced peripheral neuropathy (CIPN) is not well understood. Currently, dose reduction is the only recommendation for alleviating symptoms, often leading to premature treatment cessation. The primary aim of this analysis was to determine the association between components of diet during taxane treatment for breast cancer and change in CIPN symptoms over treatment. Methods: Women with stage II or III invasive breast cancer were enrolled into an ancillary study to the North American Breast Cancer Intergroup phase III trial (S0221) led by the Southwest Oncology Group (SWOG). Questionnaires including a food frequency questionnaire and the Functional Assessment of Cancer Treatment Gynecologic Oncology Group - Neurotoxicity were administered to assess diet and neuropathic conditions at baseline and during chemotherapy. Ordinal regression was used to estimate odds ratios (ORs) for associations between various food groups and change in neuropathy score (< 10%, 10-30%, > 30%) (n = 900). Results: The odds of worse neuropathy decreased by 21% for each increase in tertile of grain consumption (OR = 0.79, 95% CI 0.66-0.94, p = 0.009). We also observed a nominal 19% increase with higher consumption of citrus fruits (OR = 1.19, 95% CI 1.01-1.40, p = 0.05). Conclusions: Distinguishing between those who experienced a moderate and a severe change in neuropathy, we found that citrus fruit and grain consumption may play a role in the severity of symptoms. Since there are no existing dietary recommendations for the management of CIPN, further research is needed to investigate whether there may be certain foods that could worsen or alleviate neuropathy symptoms associated with treatment for breast cancer. Trial registration: ClinicalTrials.gov, NCT03413761. Registered retrospectively on 29 January 2018.

AB - Background: The pathophysiology of chemotherapy-induced peripheral neuropathy (CIPN) is not well understood. Currently, dose reduction is the only recommendation for alleviating symptoms, often leading to premature treatment cessation. The primary aim of this analysis was to determine the association between components of diet during taxane treatment for breast cancer and change in CIPN symptoms over treatment. Methods: Women with stage II or III invasive breast cancer were enrolled into an ancillary study to the North American Breast Cancer Intergroup phase III trial (S0221) led by the Southwest Oncology Group (SWOG). Questionnaires including a food frequency questionnaire and the Functional Assessment of Cancer Treatment Gynecologic Oncology Group - Neurotoxicity were administered to assess diet and neuropathic conditions at baseline and during chemotherapy. Ordinal regression was used to estimate odds ratios (ORs) for associations between various food groups and change in neuropathy score (< 10%, 10-30%, > 30%) (n = 900). Results: The odds of worse neuropathy decreased by 21% for each increase in tertile of grain consumption (OR = 0.79, 95% CI 0.66-0.94, p = 0.009). We also observed a nominal 19% increase with higher consumption of citrus fruits (OR = 1.19, 95% CI 1.01-1.40, p = 0.05). Conclusions: Distinguishing between those who experienced a moderate and a severe change in neuropathy, we found that citrus fruit and grain consumption may play a role in the severity of symptoms. Since there are no existing dietary recommendations for the management of CIPN, further research is needed to investigate whether there may be certain foods that could worsen or alleviate neuropathy symptoms associated with treatment for breast cancer. Trial registration: ClinicalTrials.gov, NCT03413761. Registered retrospectively on 29 January 2018.

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KW - Chemotherapy-induced peripheral neuropathy

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KW - Peripheral nervous system diseases

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