TY - JOUR
T1 - Associations between race, sex and immune response variations to rubella vaccination in two independent cohorts
AU - Haralambieva, Iana H.
AU - Salk, Hannah M.
AU - Lambert, Nathaniel D.
AU - Ovsyannikova, Inna G.
AU - Kennedy, Richard B.
AU - Warner, Nathaniel D.
AU - Pankratz, V. Shane
AU - Poland, Gregory A.
N1 - Funding Information:
Research reported in this publication was supported by the National Institute of Allergy and Infectious Diseases of the National Institutes of Health under award number R37 AI048793-11 (which recently received a MERIT award). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
PY - 2014/4/7
Y1 - 2014/4/7
N2 - Introduction: Immune response variations after vaccination are influenced by host genetic factors and demographic variables, such as race, ethnicity and sex. The latter have not been systematically studied in regard to live rubella vaccine, but are of interest for developing next generation vaccines for diverse populations, for predicting immune responses after vaccination, and for better understanding the variables that impact immune response. Methods: We assessed associations between demographic variables, including race, ethnicity and sex, and rubella-specific neutralizing antibody levels and secreted cytokines (IFNγ, IL-6) in two independent cohorts (1994 subjects), using linear and linear mixed models approaches, and genetically defined racial and ethnic categorizations. Results: Our replicated findings in two independent, large, racially diverse cohorts indicate that individuals of African descent have significantly higher rubella-specific neutralizing antibody levels compared to individuals of European descent and/or Hispanic ethnicity (p<0.001). Conclusion: Our study provides consistent evidence for racial/ethnic differences in humoral immune response following rubella vaccination.
AB - Introduction: Immune response variations after vaccination are influenced by host genetic factors and demographic variables, such as race, ethnicity and sex. The latter have not been systematically studied in regard to live rubella vaccine, but are of interest for developing next generation vaccines for diverse populations, for predicting immune responses after vaccination, and for better understanding the variables that impact immune response. Methods: We assessed associations between demographic variables, including race, ethnicity and sex, and rubella-specific neutralizing antibody levels and secreted cytokines (IFNγ, IL-6) in two independent cohorts (1994 subjects), using linear and linear mixed models approaches, and genetically defined racial and ethnic categorizations. Results: Our replicated findings in two independent, large, racially diverse cohorts indicate that individuals of African descent have significantly higher rubella-specific neutralizing antibody levels compared to individuals of European descent and/or Hispanic ethnicity (p<0.001). Conclusion: Our study provides consistent evidence for racial/ethnic differences in humoral immune response following rubella vaccination.
KW - Antibodies
KW - Cellular immunity
KW - Ethnicity
KW - MMR
KW - Race
KW - Rubella vaccine
KW - Sex
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U2 - 10.1016/j.vaccine.2014.01.090
DO - 10.1016/j.vaccine.2014.01.090
M3 - Article
C2 - 24530932
AN - SCOPUS:84896319594
SN - 0264-410X
VL - 32
SP - 1946
EP - 1953
JO - Vaccine
JF - Vaccine
IS - 17
ER -