Associations between polymorphisms in the antiviral TRIM genes and measles vaccine immunity

Inna G. Ovsyannikova, Iana H. Haralambieva, Robert A. Vierkant, Megan M. O'Byrne, Gregory A. Poland

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

The role of polymorphisms within the antiviral tripartite motif (TRIM) genes in measles vaccine adaptive immune responses was examined. A limited association was found between TRIM5 (rs7122620) and TRIM25 (rs205499) gene polymorphisms and measles-specific antibody levels. However, many associations were found between TRIM gene SNPs and variations in cellular responses (IFN-γ Elispot and secreted cytokines IL-2, IL-6, IL-10, IFN-γ, and TNF-α). TRIM22 rs2291841 was significantly associated with an increased IFN-γ Elispot response (35 vs. 102 SFC per 2×105PBMC, p=0.009, q=0.71) in Caucasians. A non-synonymous TRIM25 rs205498 (in LD with other SNPs, r20.56), as well as the TRIM25 AAAGGAAAGGAGT haplotype, was associated with a decreased IFN-γ Elispot response (t-statistic -2.32, p=0.02) in African-Americans. We also identified polymorphisms in the TRIM5, TRIM22, and TRIM25 genes that were associated with significant differences in cytokine responses. Additional studies are necessary to replicate our findings and to examine the functional consequences of these associations.

Original languageEnglish (US)
Pages (from-to)768-774
Number of pages7
JournalHuman Immunology
Volume74
Issue number6
DOIs
StatePublished - Jun 2013

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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    Ovsyannikova, I. G., Haralambieva, I. H., Vierkant, R. A., O'Byrne, M. M., & Poland, G. A. (2013). Associations between polymorphisms in the antiviral TRIM genes and measles vaccine immunity. Human Immunology, 74(6), 768-774. https://doi.org/10.1016/j.humimm.2013.01.031