Associations between longitudinal changes in serum estrogen, testosterone, and bioavailable testosterone and changes in benign urologic outcomes

Jennifer St. Sauver, Debra J. Jacobson, Michaela E. McGree, Cynthia J. Girman, George G. Klee, Michael M. Lieber, Steven J. Jacobsen

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Some men have rapid increases in benign prostatic enlargement and lower urinary tract symptoms (LUTS), and it is not clear how sex steroid hormones contribute to the rates of change in these urologic outcomes. Therefore, the authors conducted a population-based cohort study of 648 men residing in Olmsted County, Minnesota, from 1990 to 2007, to examine associations between baseline sex steroid hormones, the rate of change in these hormones, and the rates of change in LUTS, maximum urinary flow rate, and prostate volume. Annual changes in hormone levels and urologic outcomes were calculated using mixed-effects regression models. Associations between hormone variables and rates of change in urologic outcomes were assessed with linear regression models. Higher baseline estradiol levels and rapid declines in estradiol over time were associated with rapid increases in LUTS and rapid decreases in maximum flow rate. Lower baseline bioavailable testosterone levels and more rapid declines in bioavailable testosterone were associated with more rapid increases in prostate volume. These results suggest that both absolute sex steroid hormone levels and the rates at which the levels change may be important in the development of urologic conditions in aging men.

Original languageEnglish (US)
Pages (from-to)787-796
Number of pages10
JournalAmerican Journal of Epidemiology
Volume173
Issue number7
DOIs
StatePublished - Apr 1 2011

Fingerprint

Lower Urinary Tract Symptoms
Gonadal Steroid Hormones
Testosterone
Estrogens
Hormones
Prostate
Estradiol
Linear Models
Serum
Cohort Studies
Population

Keywords

  • estradiol
  • prostatic hyperplasia
  • testosterone

ASJC Scopus subject areas

  • Epidemiology

Cite this

Associations between longitudinal changes in serum estrogen, testosterone, and bioavailable testosterone and changes in benign urologic outcomes. / St. Sauver, Jennifer; Jacobson, Debra J.; McGree, Michaela E.; Girman, Cynthia J.; Klee, George G.; Lieber, Michael M.; Jacobsen, Steven J.

In: American Journal of Epidemiology, Vol. 173, No. 7, 01.04.2011, p. 787-796.

Research output: Contribution to journalArticle

St. Sauver, Jennifer ; Jacobson, Debra J. ; McGree, Michaela E. ; Girman, Cynthia J. ; Klee, George G. ; Lieber, Michael M. ; Jacobsen, Steven J. / Associations between longitudinal changes in serum estrogen, testosterone, and bioavailable testosterone and changes in benign urologic outcomes. In: American Journal of Epidemiology. 2011 ; Vol. 173, No. 7. pp. 787-796.
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