Association of white matter microstructural integrity with cognition and dementia

Melinda C. Power, Dan Su, Aozhou Wu, Robert I. Reid, Clifford R. Jack, David S. Knopman, Joe Coresh, Juebin Huang, Kejal Kantarci, A. Richey Sharrett, Rebecca G. Gottesman, Mike E. Griswold, Thomas H. Mosley

Research output: Contribution to journalArticle

Abstract

Late-life measures of white matter (WM) microstructural integrity may predict cognitive status, cognitive decline, and incident mild cognitive impairment (MCI) or dementia. We considered participants of the Atherosclerosis Risk in Communities study who underwent cognitive assessment and neuroimaging in 2011–2013 and were followed through 2016–2017 (n = 1775 for analyses of prevalent MCI and dementia, baseline cognitive performance, and longitudinal cognitive change and n = 889 for analyses of incident MCI, dementia, or death). Cross-sectionally, both overall WM fractional anisotropy and overall WM mean diffusivity were strongly associated with baseline cognitive performance and risk of prevalent MCI or dementia. Longitudinally, greater overall WM mean diffusivity was associated with accelerated cognitive decline, as well as incident MCI, incident dementia, and mortality, but WM fractional anisotropy was not robustly associated with cognitive change or incident cognitive impairment. Both cross-sectional and longitudinal associations were attenuated after additionally adjusting for likely downstream pathologic changes. Increased WM mean diffusivity may provide an early indication of dementia pathogenesis.

Original languageEnglish (US)
Pages (from-to)63-72
Number of pages10
JournalNeurobiology of aging
Volume83
DOIs
StatePublished - Nov 2019

Fingerprint

Cognition
Dementia
Anisotropy
Cognitive Dysfunction
White Matter
Neuroimaging
Atherosclerosis
Mortality

Keywords

  • Cognitive decline
  • Cognitive impairment
  • Dementia
  • DTI
  • MRI
  • White matter microstructural integrity

ASJC Scopus subject areas

  • Neuroscience(all)
  • Aging
  • Clinical Neurology
  • Developmental Biology
  • Geriatrics and Gerontology

Cite this

Association of white matter microstructural integrity with cognition and dementia. / Power, Melinda C.; Su, Dan; Wu, Aozhou; Reid, Robert I.; Jack, Clifford R.; Knopman, David S.; Coresh, Joe; Huang, Juebin; Kantarci, Kejal; Sharrett, A. Richey; Gottesman, Rebecca G.; Griswold, Mike E.; Mosley, Thomas H.

In: Neurobiology of aging, Vol. 83, 11.2019, p. 63-72.

Research output: Contribution to journalArticle

Power, MC, Su, D, Wu, A, Reid, RI, Jack, CR, Knopman, DS, Coresh, J, Huang, J, Kantarci, K, Sharrett, AR, Gottesman, RG, Griswold, ME & Mosley, TH 2019, 'Association of white matter microstructural integrity with cognition and dementia', Neurobiology of aging, vol. 83, pp. 63-72. https://doi.org/10.1016/j.neurobiolaging.2019.08.021
Power, Melinda C. ; Su, Dan ; Wu, Aozhou ; Reid, Robert I. ; Jack, Clifford R. ; Knopman, David S. ; Coresh, Joe ; Huang, Juebin ; Kantarci, Kejal ; Sharrett, A. Richey ; Gottesman, Rebecca G. ; Griswold, Mike E. ; Mosley, Thomas H. / Association of white matter microstructural integrity with cognition and dementia. In: Neurobiology of aging. 2019 ; Vol. 83. pp. 63-72.
@article{36d6871a7b7242f4a800734477f8a4ed,
title = "Association of white matter microstructural integrity with cognition and dementia",
abstract = "Late-life measures of white matter (WM) microstructural integrity may predict cognitive status, cognitive decline, and incident mild cognitive impairment (MCI) or dementia. We considered participants of the Atherosclerosis Risk in Communities study who underwent cognitive assessment and neuroimaging in 2011–2013 and were followed through 2016–2017 (n = 1775 for analyses of prevalent MCI and dementia, baseline cognitive performance, and longitudinal cognitive change and n = 889 for analyses of incident MCI, dementia, or death). Cross-sectionally, both overall WM fractional anisotropy and overall WM mean diffusivity were strongly associated with baseline cognitive performance and risk of prevalent MCI or dementia. Longitudinally, greater overall WM mean diffusivity was associated with accelerated cognitive decline, as well as incident MCI, incident dementia, and mortality, but WM fractional anisotropy was not robustly associated with cognitive change or incident cognitive impairment. Both cross-sectional and longitudinal associations were attenuated after additionally adjusting for likely downstream pathologic changes. Increased WM mean diffusivity may provide an early indication of dementia pathogenesis.",
keywords = "Cognitive decline, Cognitive impairment, Dementia, DTI, MRI, White matter microstructural integrity",
author = "Power, {Melinda C.} and Dan Su and Aozhou Wu and Reid, {Robert I.} and Jack, {Clifford R.} and Knopman, {David S.} and Joe Coresh and Juebin Huang and Kejal Kantarci and Sharrett, {A. Richey} and Gottesman, {Rebecca G.} and Griswold, {Mike E.} and Mosley, {Thomas H.}",
year = "2019",
month = "11",
doi = "10.1016/j.neurobiolaging.2019.08.021",
language = "English (US)",
volume = "83",
pages = "63--72",
journal = "Neurobiology of Aging",
issn = "0197-4580",
publisher = "Elsevier Inc.",

}

TY - JOUR

T1 - Association of white matter microstructural integrity with cognition and dementia

AU - Power, Melinda C.

AU - Su, Dan

AU - Wu, Aozhou

AU - Reid, Robert I.

AU - Jack, Clifford R.

AU - Knopman, David S.

AU - Coresh, Joe

AU - Huang, Juebin

AU - Kantarci, Kejal

AU - Sharrett, A. Richey

AU - Gottesman, Rebecca G.

AU - Griswold, Mike E.

AU - Mosley, Thomas H.

PY - 2019/11

Y1 - 2019/11

N2 - Late-life measures of white matter (WM) microstructural integrity may predict cognitive status, cognitive decline, and incident mild cognitive impairment (MCI) or dementia. We considered participants of the Atherosclerosis Risk in Communities study who underwent cognitive assessment and neuroimaging in 2011–2013 and were followed through 2016–2017 (n = 1775 for analyses of prevalent MCI and dementia, baseline cognitive performance, and longitudinal cognitive change and n = 889 for analyses of incident MCI, dementia, or death). Cross-sectionally, both overall WM fractional anisotropy and overall WM mean diffusivity were strongly associated with baseline cognitive performance and risk of prevalent MCI or dementia. Longitudinally, greater overall WM mean diffusivity was associated with accelerated cognitive decline, as well as incident MCI, incident dementia, and mortality, but WM fractional anisotropy was not robustly associated with cognitive change or incident cognitive impairment. Both cross-sectional and longitudinal associations were attenuated after additionally adjusting for likely downstream pathologic changes. Increased WM mean diffusivity may provide an early indication of dementia pathogenesis.

AB - Late-life measures of white matter (WM) microstructural integrity may predict cognitive status, cognitive decline, and incident mild cognitive impairment (MCI) or dementia. We considered participants of the Atherosclerosis Risk in Communities study who underwent cognitive assessment and neuroimaging in 2011–2013 and were followed through 2016–2017 (n = 1775 for analyses of prevalent MCI and dementia, baseline cognitive performance, and longitudinal cognitive change and n = 889 for analyses of incident MCI, dementia, or death). Cross-sectionally, both overall WM fractional anisotropy and overall WM mean diffusivity were strongly associated with baseline cognitive performance and risk of prevalent MCI or dementia. Longitudinally, greater overall WM mean diffusivity was associated with accelerated cognitive decline, as well as incident MCI, incident dementia, and mortality, but WM fractional anisotropy was not robustly associated with cognitive change or incident cognitive impairment. Both cross-sectional and longitudinal associations were attenuated after additionally adjusting for likely downstream pathologic changes. Increased WM mean diffusivity may provide an early indication of dementia pathogenesis.

KW - Cognitive decline

KW - Cognitive impairment

KW - Dementia

KW - DTI

KW - MRI

KW - White matter microstructural integrity

UR - http://www.scopus.com/inward/record.url?scp=85072751772&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85072751772&partnerID=8YFLogxK

U2 - 10.1016/j.neurobiolaging.2019.08.021

DO - 10.1016/j.neurobiolaging.2019.08.021

M3 - Article

C2 - 31585368

AN - SCOPUS:85072751772

VL - 83

SP - 63

EP - 72

JO - Neurobiology of Aging

JF - Neurobiology of Aging

SN - 0197-4580

ER -