Association of vitamin D receptor gene variants, adiposity and colon cancer

Heather M. Ochs-Balcom, Mine S. Cicek, Cheryl L. Thompson, Thomas C. Tucker, Robert C. Elston, Sarah J. Plummer, Graham Casey, Li Li

Research output: Contribution to journalArticle

48 Scopus citations

Abstract

Vitamin D receptor (VDR) gene variants have been variably associated with risk of colon cancer in epidemiologic studies. We sought to further clarify the relationship between colon cancer and three single-nucleotide polymorphisms (SNPs) in the VDR gene (Cdx-2, FokI and TaqI) in a population-based case-control study of 250 incident cases and 246 controls. Colon cancer cases were more frequently homozygous for the Cdx-2 A allele (9.2 versus 4.1%, P = 0.06). Cdx-2 AA homozygotes were at increased risk with an unadjusted odds ratio (OR) of 2.47 [95% confidence interval (CI): 1.13-5.37, P = 0.022]; adjustment for age, sex, body mass index (BMI), non-steroidal anti-inflammatory use and family history of colorectal cancer yielded an OR of 2.27 (CI: 0.95-5.41, P = 0.065). Carriers of the FokI TT genotype were also at increased risk with an adjusted OR of 1.87 (CI: 1.03-3.38, P = 0.038). Haplotype analyses showed significant increased colon cancer risk for carriers of the Cdx-2 -FokI A-T haplotype and the FokI-TaqI T-G haplotype. The three-SNP Cdx-2 - FokI - TaqI (A-T-G) haplotype showed a similar association with an adjusted OR of 3.63 (CI: 1.01-13.07). A strong positive association was observed for the Cdx-2 variant among individuals with low BMI or low waist circumference. Our results suggest that genetic variation at the VDR locus, in particular Cdx-2 and FokI SNPs, may influence colon cancer risk and these associations may be modified by adiposity.

Original languageEnglish (US)
Pages (from-to)1788-1793
Number of pages6
JournalCarcinogenesis
Volume29
Issue number9
DOIs
StatePublished - Sep 22 2008

    Fingerprint

ASJC Scopus subject areas

  • Cancer Research

Cite this

Ochs-Balcom, H. M., Cicek, M. S., Thompson, C. L., Tucker, T. C., Elston, R. C., Plummer, S. J., Casey, G., & Li, L. (2008). Association of vitamin D receptor gene variants, adiposity and colon cancer. Carcinogenesis, 29(9), 1788-1793. https://doi.org/10.1093/carcin/bgn166