Association of vitamin D receptor gene variants, adiposity and colon cancer

Heather M. Ochs-Balcom, Mine Cicek, Cheryl L. Thompson, Thomas C. Tucker, Robert C. Elston, Sarah J. Plummer, Graham Casey, Li Li

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Abstract

Vitamin D receptor (VDR) gene variants have been variably associated with risk of colon cancer in epidemiologic studies. We sought to further clarify the relationship between colon cancer and three single-nucleotide polymorphisms (SNPs) in the VDR gene (Cdx-2, FokI and TaqI) in a population-based case-control study of 250 incident cases and 246 controls. Colon cancer cases were more frequently homozygous for the Cdx-2 A allele (9.2 versus 4.1%, P = 0.06). Cdx-2 AA homozygotes were at increased risk with an unadjusted odds ratio (OR) of 2.47 [95% confidence interval (CI): 1.13-5.37, P = 0.022]; adjustment for age, sex, body mass index (BMI), non-steroidal anti-inflammatory use and family history of colorectal cancer yielded an OR of 2.27 (CI: 0.95-5.41, P = 0.065). Carriers of the FokI TT genotype were also at increased risk with an adjusted OR of 1.87 (CI: 1.03-3.38, P = 0.038). Haplotype analyses showed significant increased colon cancer risk for carriers of the Cdx-2 -FokI A-T haplotype and the FokI-TaqI T-G haplotype. The three-SNP Cdx-2 - FokI - TaqI (A-T-G) haplotype showed a similar association with an adjusted OR of 3.63 (CI: 1.01-13.07). A strong positive association was observed for the Cdx-2 variant among individuals with low BMI or low waist circumference. Our results suggest that genetic variation at the VDR locus, in particular Cdx-2 and FokI SNPs, may influence colon cancer risk and these associations may be modified by adiposity.

Original languageEnglish (US)
Pages (from-to)1788-1793
Number of pages6
JournalCarcinogenesis
Volume29
Issue number9
DOIs
StatePublished - 2008

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Calcitriol Receptors
Adiposity
Colonic Neoplasms
Haplotypes
Odds Ratio
Confidence Intervals
Single Nucleotide Polymorphism
Genes
Body Mass Index
Homozygote
Waist Circumference
Case-Control Studies
Epidemiologic Studies
Colorectal Neoplasms
Anti-Inflammatory Agents
Alleles
Genotype
Population

ASJC Scopus subject areas

  • Cancer Research

Cite this

Ochs-Balcom, H. M., Cicek, M., Thompson, C. L., Tucker, T. C., Elston, R. C., Plummer, S. J., ... Li, L. (2008). Association of vitamin D receptor gene variants, adiposity and colon cancer. Carcinogenesis, 29(9), 1788-1793. https://doi.org/10.1093/carcin/bgn166

Association of vitamin D receptor gene variants, adiposity and colon cancer. / Ochs-Balcom, Heather M.; Cicek, Mine; Thompson, Cheryl L.; Tucker, Thomas C.; Elston, Robert C.; Plummer, Sarah J.; Casey, Graham; Li, Li.

In: Carcinogenesis, Vol. 29, No. 9, 2008, p. 1788-1793.

Research output: Contribution to journalArticle

Ochs-Balcom, HM, Cicek, M, Thompson, CL, Tucker, TC, Elston, RC, Plummer, SJ, Casey, G & Li, L 2008, 'Association of vitamin D receptor gene variants, adiposity and colon cancer', Carcinogenesis, vol. 29, no. 9, pp. 1788-1793. https://doi.org/10.1093/carcin/bgn166
Ochs-Balcom HM, Cicek M, Thompson CL, Tucker TC, Elston RC, Plummer SJ et al. Association of vitamin D receptor gene variants, adiposity and colon cancer. Carcinogenesis. 2008;29(9):1788-1793. https://doi.org/10.1093/carcin/bgn166
Ochs-Balcom, Heather M. ; Cicek, Mine ; Thompson, Cheryl L. ; Tucker, Thomas C. ; Elston, Robert C. ; Plummer, Sarah J. ; Casey, Graham ; Li, Li. / Association of vitamin D receptor gene variants, adiposity and colon cancer. In: Carcinogenesis. 2008 ; Vol. 29, No. 9. pp. 1788-1793.
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