Association of two variants in IL-1β and IL-1 receptor antagonist genes with multiple sclerosis

Orhun H. Kantarci, Elizabeth J. Atkinson, David D. Hebrink, Cynthia T. McMurray, Brian G. Weinshenker

Research output: Contribution to journalArticle

61 Scopus citations

Abstract

We studied the putative association of a C→T polymorphism in exon-5 of IL-1β and an 85 bp tandem repeat in intron-4 of IL-1 receptor antagonist (IL-1ra) genes with susceptibility to or outcome of MS. DNA from 122 cases from a population-based cohort in Olmsted County, MN who were previously categorized for disease severity and temporal course and 244 ethnically- matched controls were analyzed. There was no association between either polymorphism and disease susceptibility. Allele-2 of IL-1β and allele-3 of the IL-1ra polymorphisms were associated with a favorable outcome (P=0.023 and P=0.030). (C) 2000 Elsevier Science B.V.

Original languageEnglish (US)
Pages (from-to)220-227
Number of pages8
JournalJournal of neuroimmunology
Volume106
Issue number1-2
DOIs
StatePublished - Jul 1 2000

Keywords

  • Genetics
  • IL-1 receptor antagonist
  • Interleukin-1
  • Multiple sclerosis
  • Prognosis
  • Susceptibility

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology

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