Association of two variants in IL-1β and IL-1 receptor antagonist genes with multiple sclerosis

Orhun H. Kantarci; Elizabeth J. Atkinson; David D. Hebrink; Cynthia T. McMurray; Brian G. Weinshenker

doi:10.1016/S0165-5728(00)00202-2

Association of two variants in IL-1β and IL-1 receptor antagonist genes with multiple sclerosis

Orhun H. Kantarci, Elizabeth J. Atkinson, David D. Hebrink, Cynthia T. McMurray, Brian G. Weinshenker

Neurology

Research output: Contribution to journal › Article › peer-review

62 Scopus citations

Abstract

We studied the putative association of a C→T polymorphism in exon-5 of IL-1β and an 85 bp tandem repeat in intron-4 of IL-1 receptor antagonist (IL-1ra) genes with susceptibility to or outcome of MS. DNA from 122 cases from a population-based cohort in Olmsted County, MN who were previously categorized for disease severity and temporal course and 244 ethnically- matched controls were analyzed. There was no association between either polymorphism and disease susceptibility. Allele-2 of IL-1β and allele-3 of the IL-1ra polymorphisms were associated with a favorable outcome (P=0.023 and P=0.030). (C) 2000 Elsevier Science B.V.

Original language	English (US)
Pages (from-to)	220-227
Number of pages	8
Journal	Journal of neuroimmunology
Volume	106
Issue number	1-2
DOIs	https://doi.org/10.1016/S0165-5728(00)00202-2
State	Published - Jul 1 2000

Keywords

Genetics
IL-1 receptor antagonist
Interleukin-1
Multiple sclerosis
Prognosis
Susceptibility

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Neurology
Clinical Neurology

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10.1016/S0165-5728(00)00202-2

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title = "Association of two variants in IL-1β and IL-1 receptor antagonist genes with multiple sclerosis",

abstract = "We studied the putative association of a C→T polymorphism in exon-5 of IL-1β and an 85 bp tandem repeat in intron-4 of IL-1 receptor antagonist (IL-1ra) genes with susceptibility to or outcome of MS. DNA from 122 cases from a population-based cohort in Olmsted County, MN who were previously categorized for disease severity and temporal course and 244 ethnically- matched controls were analyzed. There was no association between either polymorphism and disease susceptibility. Allele-2 of IL-1β and allele-3 of the IL-1ra polymorphisms were associated with a favorable outcome (P=0.023 and P=0.030). (C) 2000 Elsevier Science B.V.",

keywords = "Genetics, IL-1 receptor antagonist, Interleukin-1, Multiple sclerosis, Prognosis, Susceptibility",

author = "Kantarci, {Orhun H.} and Atkinson, {Elizabeth J.} and Hebrink, {David D.} and McMurray, {Cynthia T.} and Weinshenker, {Brian G.}",

note = "Funding Information: This study has been supported by the National MS Society, grant no.: RG-2870-A-2. Dr.McMurray is supported by the Mayo Foundation, grant no.:DK 43694-01A2 and National Institutes of Health grant no.:MH-56207. Dr.Kantarci has been supported by a NATO Science Fellowship Program granted by the Scientific and Technical Research Council of Turkey and is currently supported by an advanced fellowship award granted by the National MS Society.",

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doi = "10.1016/S0165-5728(00)00202-2",

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AU - Kantarci, Orhun H.

AU - Atkinson, Elizabeth J.

AU - Hebrink, David D.

AU - McMurray, Cynthia T.

AU - Weinshenker, Brian G.

N1 - Funding Information: This study has been supported by the National MS Society, grant no.: RG-2870-A-2. Dr.McMurray is supported by the Mayo Foundation, grant no.:DK 43694-01A2 and National Institutes of Health grant no.:MH-56207. Dr.Kantarci has been supported by a NATO Science Fellowship Program granted by the Scientific and Technical Research Council of Turkey and is currently supported by an advanced fellowship award granted by the National MS Society.

PY - 2000/7/1

Y1 - 2000/7/1

N2 - We studied the putative association of a C→T polymorphism in exon-5 of IL-1β and an 85 bp tandem repeat in intron-4 of IL-1 receptor antagonist (IL-1ra) genes with susceptibility to or outcome of MS. DNA from 122 cases from a population-based cohort in Olmsted County, MN who were previously categorized for disease severity and temporal course and 244 ethnically- matched controls were analyzed. There was no association between either polymorphism and disease susceptibility. Allele-2 of IL-1β and allele-3 of the IL-1ra polymorphisms were associated with a favorable outcome (P=0.023 and P=0.030). (C) 2000 Elsevier Science B.V.

AB - We studied the putative association of a C→T polymorphism in exon-5 of IL-1β and an 85 bp tandem repeat in intron-4 of IL-1 receptor antagonist (IL-1ra) genes with susceptibility to or outcome of MS. DNA from 122 cases from a population-based cohort in Olmsted County, MN who were previously categorized for disease severity and temporal course and 244 ethnically- matched controls were analyzed. There was no association between either polymorphism and disease susceptibility. Allele-2 of IL-1β and allele-3 of the IL-1ra polymorphisms were associated with a favorable outcome (P=0.023 and P=0.030). (C) 2000 Elsevier Science B.V.

KW - Genetics

KW - IL-1 receptor antagonist

KW - Interleukin-1

KW - Multiple sclerosis

KW - Prognosis

KW - Susceptibility

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Association of two variants in IL-1β and IL-1 receptor antagonist genes with multiple sclerosis

Abstract

Keywords

ASJC Scopus subject areas

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