TY - JOUR
T1 - Association of TNFSF8 polymorphisms with peripheral neutrophil count
AU - Arruda-Olson, Adelaide M.
AU - Roger, Veŕonique L.
AU - Chai, High S.
AU - De Andrade, Mariza
AU - Fridley, Brooke L.
AU - Cunningham, Julie M.
AU - Gabriel, Sherine E.
AU - Bielinski, Suzette J.
N1 - Funding Information:
This study was supported by grants from a Clinician Investigator Fellowship Award from Mayo Clinic; grants from the Public Health Service; and the National Institutes of Health (R03 AG031347-01, R01 HL 59205, R01 HL 72435) and was made possible by the Rochester Epidemiology Project (AG034676, National Institute on Aging).
PY - 2011/11
Y1 - 2011/11
N2 - OBJECTIVE: To investigate the association between 347 single-nucleotide polymorphisms within candidate genes of the tumor necrosis factor, interleukin 1 and interleukin 6 families with neutrophil count. PATIENTS AND METHODS: Four hundred cases with heart failure after myocardial infarction (MI) were matched by age, sex, and date of incident MI to 694 controls (MI without post-MI heart failure). Both genotypes and neutrophil count at admission for incident MI were available in 314 cases and 515 controls. RESULTS: We found significant associations between the TNFSF8 polymorphisms rs927374 (P=5.1 × 10 -5) and rs2295800 (P=1.3 × 10-4) and neutrophil count; these single-nucleotide polymorphisms are in high linkage disequilibrium (r2=0.97). Associations persisted after controlling for clinical characteristics and were unchanged after adjusting for case-control status. For rs927374, the neutrophil count of GG homozygotes (7.6±5.1) was 16% lower than that of CC homozygotes (9.0±5.2). CONCLUSION: The TNFSF8 polymorphisms rs927374 and rs2295800 were associated with neutrophil count. This finding suggests that post-MI inflammatory response is genetically modulated.
AB - OBJECTIVE: To investigate the association between 347 single-nucleotide polymorphisms within candidate genes of the tumor necrosis factor, interleukin 1 and interleukin 6 families with neutrophil count. PATIENTS AND METHODS: Four hundred cases with heart failure after myocardial infarction (MI) were matched by age, sex, and date of incident MI to 694 controls (MI without post-MI heart failure). Both genotypes and neutrophil count at admission for incident MI were available in 314 cases and 515 controls. RESULTS: We found significant associations between the TNFSF8 polymorphisms rs927374 (P=5.1 × 10 -5) and rs2295800 (P=1.3 × 10-4) and neutrophil count; these single-nucleotide polymorphisms are in high linkage disequilibrium (r2=0.97). Associations persisted after controlling for clinical characteristics and were unchanged after adjusting for case-control status. For rs927374, the neutrophil count of GG homozygotes (7.6±5.1) was 16% lower than that of CC homozygotes (9.0±5.2). CONCLUSION: The TNFSF8 polymorphisms rs927374 and rs2295800 were associated with neutrophil count. This finding suggests that post-MI inflammatory response is genetically modulated.
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U2 - 10.4065/mcp.2011.0275
DO - 10.4065/mcp.2011.0275
M3 - Article
C2 - 22033252
AN - SCOPUS:80055072958
SN - 0025-6196
VL - 86
SP - 1075
EP - 1081
JO - Mayo Clinic proceedings
JF - Mayo Clinic proceedings
IS - 11
ER -