Association of TNFSF8 polymorphisms with peripheral neutrophil count

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Abstract

OBJECTIVE: To investigate the association between 347 single-nucleotide polymorphisms within candidate genes of the tumor necrosis factor, interleukin 1 and interleukin 6 families with neutrophil count. PATIENTS AND METHODS: Four hundred cases with heart failure after myocardial infarction (MI) were matched by age, sex, and date of incident MI to 694 controls (MI without post-MI heart failure). Both genotypes and neutrophil count at admission for incident MI were available in 314 cases and 515 controls. RESULTS: We found significant associations between the TNFSF8 polymorphisms rs927374 (P=5.1 × 10 -5) and rs2295800 (P=1.3 × 10-4) and neutrophil count; these single-nucleotide polymorphisms are in high linkage disequilibrium (r2=0.97). Associations persisted after controlling for clinical characteristics and were unchanged after adjusting for case-control status. For rs927374, the neutrophil count of GG homozygotes (7.6±5.1) was 16% lower than that of CC homozygotes (9.0±5.2). CONCLUSION: The TNFSF8 polymorphisms rs927374 and rs2295800 were associated with neutrophil count. This finding suggests that post-MI inflammatory response is genetically modulated.

Original languageEnglish (US)
Pages (from-to)1075-1081
Number of pages7
JournalMayo Clinic proceedings
Volume86
Issue number11
DOIs
StatePublished - Nov 2011

ASJC Scopus subject areas

  • Medicine(all)

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