Association of sporadic and familial Barrett's esophagus with breast cancer

M. Q. Chan, A. E. Blum, A. K. Chandar, A. M.L.Kieber Emmons, Y. Shindo, W. Brock, G. W. Falk, M. I. Canto, J. S. Wang, Prasad G Iyer, N. J. Shaheen, W. M. Grady, J. A. Abrams, P. N. Thota, K. K. Guda, Amitabh Chak

Research output: Contribution to journalArticle

Abstract

Barrett's esophagus (BE) is the only known precursor to esophageal adenocarcinoma (EAC). Based on striking aggregation of breast cancer and BE/EAC within families as well as shared risk factors and molecular mechanisms of carcinogenesis, we hypothesized that BE may be associated with breast cancer. Pedigree analysis of families identified prospectively at multiple academic centers as part of the Familial Barrett's Esophagus Consortium (FBEC) was reviewed and families with aggregation of BE/EACand breast cancer are reported. Additionally, using a matched case-control study design, we compared newly diagnosed BE cases in Caucasian females with breast cancer (cases) to Caucasian females without breast cancer (controls) who had undergone upper endoscopy (EGD). Two familial pedigrees, meeting a stringent inclusion criterion, manifested familial aggregation of BE/EAC and breast cancer in an autosomal dominant inheritance pattern with incomplete penetrance. From January 2008 to October 2016, 2812 breast cancer patient charts were identified, of which 213 were Caucasian females who underwent EGD. Six of 213 (2.82%) patients with breast cancer had pathology-confirmed BE, compared to 1 of 241 (0.41%) controls (P-value < 0.05). Selected families with BE/EAC show segregation of breast cancer. A breast cancer diagnosis is marginally associated with BE. We postulate a common susceptibility between BE/EAC and breast cancer.

Original languageEnglish (US)
Article numberdoy007
JournalDiseases of the Esophagus
Volume31
Issue number4
DOIs
StatePublished - Apr 1 2018

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Barrett Esophagus
Breast Neoplasms
Adenocarcinoma
Esophageal Neoplasms
Pedigree
Inheritance Patterns
Penetrance
Endoscopy
Case-Control Studies
Carcinogenesis
Pathology

Keywords

  • Barrett's esophagus
  • Breast cancer
  • Cancer epidemiology

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Chan, M. Q., Blum, A. E., Chandar, A. K., Emmons, A. M. L. K., Shindo, Y., Brock, W., ... Chak, A. (2018). Association of sporadic and familial Barrett's esophagus with breast cancer. Diseases of the Esophagus, 31(4), [doy007]. https://doi.org/10.1093/dote/doy007

Association of sporadic and familial Barrett's esophagus with breast cancer. / Chan, M. Q.; Blum, A. E.; Chandar, A. K.; Emmons, A. M.L.Kieber; Shindo, Y.; Brock, W.; Falk, G. W.; Canto, M. I.; Wang, J. S.; Iyer, Prasad G; Shaheen, N. J.; Grady, W. M.; Abrams, J. A.; Thota, P. N.; Guda, K. K.; Chak, Amitabh.

In: Diseases of the Esophagus, Vol. 31, No. 4, doy007, 01.04.2018.

Research output: Contribution to journalArticle

Chan, MQ, Blum, AE, Chandar, AK, Emmons, AMLK, Shindo, Y, Brock, W, Falk, GW, Canto, MI, Wang, JS, Iyer, PG, Shaheen, NJ, Grady, WM, Abrams, JA, Thota, PN, Guda, KK & Chak, A 2018, 'Association of sporadic and familial Barrett's esophagus with breast cancer', Diseases of the Esophagus, vol. 31, no. 4, doy007. https://doi.org/10.1093/dote/doy007
Chan MQ, Blum AE, Chandar AK, Emmons AMLK, Shindo Y, Brock W et al. Association of sporadic and familial Barrett's esophagus with breast cancer. Diseases of the Esophagus. 2018 Apr 1;31(4). doy007. https://doi.org/10.1093/dote/doy007
Chan, M. Q. ; Blum, A. E. ; Chandar, A. K. ; Emmons, A. M.L.Kieber ; Shindo, Y. ; Brock, W. ; Falk, G. W. ; Canto, M. I. ; Wang, J. S. ; Iyer, Prasad G ; Shaheen, N. J. ; Grady, W. M. ; Abrams, J. A. ; Thota, P. N. ; Guda, K. K. ; Chak, Amitabh. / Association of sporadic and familial Barrett's esophagus with breast cancer. In: Diseases of the Esophagus. 2018 ; Vol. 31, No. 4.
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