TY - JOUR
T1 - Association of Spontaneous Coronary Artery Dissection With Atrial Arrhythmias
AU - Tarabochia, Alex D.
AU - Tan, Nicholas Y.
AU - Lewis, Bradley R.
AU - Slusser, Joshua P.
AU - Hayes, Sharonne N.
AU - Best, Patricia J.M.
AU - Gulati, Rajiv
AU - Deshmukh, Abhishek J.
AU - Tweet, Marysia S.
N1 - Funding Information:
This project was funded by the Department of Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota, and SCAD Research, Inc., Scottsdale, Arizona. Dr. Tweet was supported by the Office of Research on Women's Health (National Institutes of Health [Bethesda, Maryland] HD65987) during this study.
Funding Information:
The authors sincerely thank the Mayo Clinic SCAD Registry participants who volunteered their data for this study. They also thank Jill Boyum, Rachel Geroux, BS, and Sue Milbrandt, CCRC, for their assistance with the Mayo Clinic SCAD Registry. The authors have no conflicts of interest to declare. This project was funded by the Department of Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota, and SCAD Research, Inc., Scottsdale, Arizona. Dr. Tweet was supported by the Office of Research on Women's Health (National Institutes of Health [Bethesda, Maryland] HD65987) during this study.
Publisher Copyright:
© 2022 Elsevier Inc.
PY - 2023/1/1
Y1 - 2023/1/1
N2 - The co-morbidities and long-term complications of spontaneous coronary artery dissection (SCAD) are incompletely understood. This study investigated the association of atrial arrhythmias (AA), defined as atrial fibrillation and atrial flutter, with SCAD in a patient registry and population-based cohort. This observational study was performed in 2 parts. The first was a retrospective study reviewing patients diagnosed with AA in the Mayo Clinic SCAD Registry. The second was a population-based, case-control study to assess AA in patients with SCAD compared with age- and gender-matched controls. Of 1,214 patients in the Mayo Clinic SCAD Registry, 45 patients (3.7%) with SCAD were identified with an AA. A total of 8 of those patients (17.8%) had a pre-SCAD AA; 20 (44.4%) had a peri-SCAD AA; and 17 (37.8%) had a post-SCAD AA. The univariate analysis did not reveal significant associations with traditional cardiovascular risk factors. In the population-based cohort, 5 patients with SCAD (4%) and 4 controls (1%) developed an AA before the date of SCAD for each patient (odds ratio 4.5, 95% confidence interval [CI] 1.05 to 19.0, p = 0.04). A total of 5 patients with SCAD (4%) and 3 controls (1%) developed an AA in the 10 years after SCAD (hazard ratio 6.3, 95% CI 1.2 to 32.8, p = 0.03). A subgroup of patients with SCAD experienced AA before and after SCAD. Patients with a history of SCAD were more likely to develop AA in the next 10 years than were age- and gender-matched healthy controls.
AB - The co-morbidities and long-term complications of spontaneous coronary artery dissection (SCAD) are incompletely understood. This study investigated the association of atrial arrhythmias (AA), defined as atrial fibrillation and atrial flutter, with SCAD in a patient registry and population-based cohort. This observational study was performed in 2 parts. The first was a retrospective study reviewing patients diagnosed with AA in the Mayo Clinic SCAD Registry. The second was a population-based, case-control study to assess AA in patients with SCAD compared with age- and gender-matched controls. Of 1,214 patients in the Mayo Clinic SCAD Registry, 45 patients (3.7%) with SCAD were identified with an AA. A total of 8 of those patients (17.8%) had a pre-SCAD AA; 20 (44.4%) had a peri-SCAD AA; and 17 (37.8%) had a post-SCAD AA. The univariate analysis did not reveal significant associations with traditional cardiovascular risk factors. In the population-based cohort, 5 patients with SCAD (4%) and 4 controls (1%) developed an AA before the date of SCAD for each patient (odds ratio 4.5, 95% confidence interval [CI] 1.05 to 19.0, p = 0.04). A total of 5 patients with SCAD (4%) and 3 controls (1%) developed an AA in the 10 years after SCAD (hazard ratio 6.3, 95% CI 1.2 to 32.8, p = 0.03). A subgroup of patients with SCAD experienced AA before and after SCAD. Patients with a history of SCAD were more likely to develop AA in the next 10 years than were age- and gender-matched healthy controls.
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U2 - 10.1016/j.amjcard.2022.09.032
DO - 10.1016/j.amjcard.2022.09.032
M3 - Article
AN - SCOPUS:85141281148
VL - 186
SP - 203
EP - 208
JO - American Journal of Cardiology
JF - American Journal of Cardiology
SN - 0002-9149
ER -