Association of smoking and obesity on the risk of developing primary Sjögren syndrome: A Population-based Cohort Study

Luisa Servioli, Gabriel Maciel, Carlotta Nannini, Cynthia S. Crowson, Eric L. Matteson, Divi Cornec, Alvise Berti

Research output: Contribution to journalArticle

Abstract

Objective. To explore the role of smoking and obesity in primary Sjögren syndrome (pSS). Methods. Olmsted County (Minnesota, USA) residents (n = 106) diagnosed with pSS from 2000 to 2015 were compared to 3 controls without pSS and matched for age and sex who were randomly selected from Olmsted County residents. Results. Current smokers were less likely to be pSS cases (OR 0.34, 95% CI 0.14-0.85), while there was no association between former smoking and case/control status (OR 1.27, 95% CI 0.80-2.03) compared to never smokers. Smoking status was not associated with antinuclear antibody, anti-SSA, anti-SSB, or rheumatoid factor positivity (p > 0.05). OR for obesity was 0.79 (95% CI 0.48-1.30). Conclusion. In this population-based study, current smoking was inversely associated with case/control status, while body mass index lacked any association.

Original languageEnglish (US)
Pages (from-to)727-730
Number of pages4
JournalJournal of Rheumatology
Volume46
Issue number7
DOIs
StatePublished - 2019

Keywords

  • Epidemiology
  • Obesity
  • SjÖgren Syndrome
  • Smoking

ASJC Scopus subject areas

  • Rheumatology
  • Immunology and Allergy
  • Immunology

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