Association of prenatal exposure to persistent organic pollutants with obesity and cardiometabolic traits in early childhood: The rhea mother–child cohort (Crete, Greece)

Marina Vafeiadi; Vaggelis Georgiou; Georgia Chalkiadaki; Panu Rantakokko; Hannu Kiviranta; Marianna Karachaliou; Eleni Fthenou; Maria Venihaki; Katerina Sarri; Maria Vassilaki; Soterios A. Kyrtopoulos; Emily Oken; Manolis Kogevinas; Leda Chatzi

doi:10.1289/ehp.1409062

Association of prenatal exposure to persistent organic pollutants with obesity and cardiometabolic traits in early childhood: The rhea mother–child cohort (Crete, Greece)

Marina Vafeiadi, Vaggelis Georgiou, Georgia Chalkiadaki, Panu Rantakokko, Hannu Kiviranta, Marianna Karachaliou, Eleni Fthenou, Maria Venihaki, Katerina Sarri, Maria Vassilaki, Soterios A. Kyrtopoulos, Emily Oken, Manolis Kogevinas, Leda Chatzi

Quantitative Health Sciences

Research output: Contribution to journal › Article › peer-review

69 Scopus citations

Abstract

Background: Prenatal exposure to endocrine-disrupting chemicals such as persistent organic pollutants (POPs) may increase risk of obesity later in life. Objective: We examined the relation of in utero POPs exposure to offspring obesity and cardiometabolic risk factors at 4 years of age in the Rhea mother–child cohort in Crete, Greece (n = 689). Methods: We determined concentrations of polychlorinated biphenyls (PCBs), dichlorodiphenyldichloroethylene (DDE), and hexachlorobenzene (HCB) in first-trimester maternal serum. We measured child weight, height, waist circumference, skinfold thicknesses, blood pressure (BP), blood levels of lipids, C-reactive protein, and adipokines at 4 years of age. Childhood obesity was defined using age- and sex-specific cut points for body mass index (BMI) as recommended by the International Obesity Task Force. Results: On multivariable regression analyses, a 10-fold increase in HCB was associated with a higher BMI z-score (adjusted β = 0.49; 95% CI: 0.12, 0.86), obesity [relative risk (RR) = 8.14; 95% CI: 1.85, 35.81], abdominal obesity (RR = 3.49; 95% CI: 1.08, 11.28), greater sum of skinfold thickness (β = 7.71 mm; 95% CI: 2.04, 13.39), and higher systolic BP (β = 4.34 mmHg; 95% CI: 0.63, 8.05) at 4 years of age. Prenatal DDE exposure was associated with higher BMI z-score (β = 0.27; 95% CI: 0.04, 0.5), abdominal obesity (RR = 3.76; 95% CI: 1.70, 8.30), and higher diastolic BP (β = 1.79 mmHg; 95% CI: 0.13, 3.46). PCBs were not significantly associated with offspring obesity or cardiometabolic risk factors. Conclusions: Prenatal exposure to DDE and HCB was associated with excess adiposity and higher blood pressure levels in early childhood. Citation: Vafeiadi M, Georgiou V, Chalkiadaki G, Rantakokko P, Kiviranta H, Karachaliou M, Fthenou E, Venihaki M, Sarri K, Vassilaki M, Kyrtopoulos SA, Oken E, Kogevinas M, Chatzi L. 2015. Association of prenatal exposure to persistent organic pollutants with obesity and cardiometabolic traits in early childhood: the Rhea mother–child cohort (Crete, Greece).

Original language	English (US)
Pages (from-to)	1015-1021
Number of pages	7
Journal	Environmental Health Perspectives
Volume	123
Issue number	10
DOIs	https://doi.org/10.1289/ehp.1409062
State	Published - Oct 2015

ASJC Scopus subject areas

Public Health, Environmental and Occupational Health
Health, Toxicology and Mutagenesis

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10.1289/ehp.1409062

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Vafeiadi, M., Georgiou, V., Chalkiadaki, G., Rantakokko, P., Kiviranta, H., Karachaliou, M., Fthenou, E., Venihaki, M., Sarri, K., Vassilaki, M., Kyrtopoulos, S. A., Oken, E., Kogevinas, M., & Chatzi, L. (2015). Association of prenatal exposure to persistent organic pollutants with obesity and cardiometabolic traits in early childhood: The rhea mother–child cohort (Crete, Greece). Environmental Health Perspectives, 123(10), 1015-1021. https://doi.org/10.1289/ehp.1409062

Association of prenatal exposure to persistent organic pollutants with obesity and cardiometabolic traits in early childhood: The rhea mother–child cohort (Crete, Greece). / Vafeiadi, Marina; Georgiou, Vaggelis; Chalkiadaki, Georgia et al.
In: Environmental Health Perspectives, Vol. 123, No. 10, 10.2015, p. 1015-1021.

Research output: Contribution to journal › Article › peer-review

Vafeiadi, M, Georgiou, V, Chalkiadaki, G, Rantakokko, P, Kiviranta, H, Karachaliou, M, Fthenou, E, Venihaki, M, Sarri, K, Vassilaki, M, Kyrtopoulos, SA, Oken, E, Kogevinas, M & Chatzi, L 2015, 'Association of prenatal exposure to persistent organic pollutants with obesity and cardiometabolic traits in early childhood: The rhea mother–child cohort (Crete, Greece)', Environmental Health Perspectives, vol. 123, no. 10, pp. 1015-1021. https://doi.org/10.1289/ehp.1409062

@article{c3f9045b1cc5435d82a0cb01d9c8b082,

title = "Association of prenatal exposure to persistent organic pollutants with obesity and cardiometabolic traits in early childhood: The rhea mother–child cohort (Crete, Greece)",

abstract = "Background: Prenatal exposure to endocrine-disrupting chemicals such as persistent organic pollutants (POPs) may increase risk of obesity later in life. Objective: We examined the relation of in utero POPs exposure to offspring obesity and cardiometabolic risk factors at 4 years of age in the Rhea mother–child cohort in Crete, Greece (n = 689). Methods: We determined concentrations of polychlorinated biphenyls (PCBs), dichlorodiphenyldichloroethylene (DDE), and hexachlorobenzene (HCB) in first-trimester maternal serum. We measured child weight, height, waist circumference, skinfold thicknesses, blood pressure (BP), blood levels of lipids, C-reactive protein, and adipokines at 4 years of age. Childhood obesity was defined using age- and sex-specific cut points for body mass index (BMI) as recommended by the International Obesity Task Force. Results: On multivariable regression analyses, a 10-fold increase in HCB was associated with a higher BMI z-score (adjusted β = 0.49; 95% CI: 0.12, 0.86), obesity [relative risk (RR) = 8.14; 95% CI: 1.85, 35.81], abdominal obesity (RR = 3.49; 95% CI: 1.08, 11.28), greater sum of skinfold thickness (β = 7.71 mm; 95% CI: 2.04, 13.39), and higher systolic BP (β = 4.34 mmHg; 95% CI: 0.63, 8.05) at 4 years of age. Prenatal DDE exposure was associated with higher BMI z-score (β = 0.27; 95% CI: 0.04, 0.5), abdominal obesity (RR = 3.76; 95% CI: 1.70, 8.30), and higher diastolic BP (β = 1.79 mmHg; 95% CI: 0.13, 3.46). PCBs were not significantly associated with offspring obesity or cardiometabolic risk factors. Conclusions: Prenatal exposure to DDE and HCB was associated with excess adiposity and higher blood pressure levels in early childhood. Citation: Vafeiadi M, Georgiou V, Chalkiadaki G, Rantakokko P, Kiviranta H, Karachaliou M, Fthenou E, Venihaki M, Sarri K, Vassilaki M, Kyrtopoulos SA, Oken E, Kogevinas M, Chatzi L. 2015. Association of prenatal exposure to persistent organic pollutants with obesity and cardiometabolic traits in early childhood: the Rhea mother–child cohort (Crete, Greece).",

author = "Marina Vafeiadi and Vaggelis Georgiou and Georgia Chalkiadaki and Panu Rantakokko and Hannu Kiviranta and Marianna Karachaliou and Eleni Fthenou and Maria Venihaki and Katerina Sarri and Maria Vassilaki and Kyrtopoulos, {Soterios A.} and Emily Oken and Manolis Kogevinas and Leda Chatzi",

year = "2015",

month = oct,

doi = "10.1289/ehp.1409062",

language = "English (US)",

volume = "123",

pages = "1015--1021",

journal = "Environmental Health Perspectives",

issn = "0091-6765",

publisher = "Public Health Services, US Dept of Health and Human Services",

number = "10",

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TY - JOUR

T1 - Association of prenatal exposure to persistent organic pollutants with obesity and cardiometabolic traits in early childhood

T2 - The rhea mother–child cohort (Crete, Greece)

AU - Vafeiadi, Marina

AU - Georgiou, Vaggelis

AU - Chalkiadaki, Georgia

AU - Rantakokko, Panu

AU - Kiviranta, Hannu

AU - Karachaliou, Marianna

AU - Fthenou, Eleni

AU - Venihaki, Maria

AU - Sarri, Katerina

AU - Vassilaki, Maria

AU - Kyrtopoulos, Soterios A.

AU - Oken, Emily

AU - Kogevinas, Manolis

AU - Chatzi, Leda

PY - 2015/10

Y1 - 2015/10

N2 - Background: Prenatal exposure to endocrine-disrupting chemicals such as persistent organic pollutants (POPs) may increase risk of obesity later in life. Objective: We examined the relation of in utero POPs exposure to offspring obesity and cardiometabolic risk factors at 4 years of age in the Rhea mother–child cohort in Crete, Greece (n = 689). Methods: We determined concentrations of polychlorinated biphenyls (PCBs), dichlorodiphenyldichloroethylene (DDE), and hexachlorobenzene (HCB) in first-trimester maternal serum. We measured child weight, height, waist circumference, skinfold thicknesses, blood pressure (BP), blood levels of lipids, C-reactive protein, and adipokines at 4 years of age. Childhood obesity was defined using age- and sex-specific cut points for body mass index (BMI) as recommended by the International Obesity Task Force. Results: On multivariable regression analyses, a 10-fold increase in HCB was associated with a higher BMI z-score (adjusted β = 0.49; 95% CI: 0.12, 0.86), obesity [relative risk (RR) = 8.14; 95% CI: 1.85, 35.81], abdominal obesity (RR = 3.49; 95% CI: 1.08, 11.28), greater sum of skinfold thickness (β = 7.71 mm; 95% CI: 2.04, 13.39), and higher systolic BP (β = 4.34 mmHg; 95% CI: 0.63, 8.05) at 4 years of age. Prenatal DDE exposure was associated with higher BMI z-score (β = 0.27; 95% CI: 0.04, 0.5), abdominal obesity (RR = 3.76; 95% CI: 1.70, 8.30), and higher diastolic BP (β = 1.79 mmHg; 95% CI: 0.13, 3.46). PCBs were not significantly associated with offspring obesity or cardiometabolic risk factors. Conclusions: Prenatal exposure to DDE and HCB was associated with excess adiposity and higher blood pressure levels in early childhood. Citation: Vafeiadi M, Georgiou V, Chalkiadaki G, Rantakokko P, Kiviranta H, Karachaliou M, Fthenou E, Venihaki M, Sarri K, Vassilaki M, Kyrtopoulos SA, Oken E, Kogevinas M, Chatzi L. 2015. Association of prenatal exposure to persistent organic pollutants with obesity and cardiometabolic traits in early childhood: the Rhea mother–child cohort (Crete, Greece).

AB - Background: Prenatal exposure to endocrine-disrupting chemicals such as persistent organic pollutants (POPs) may increase risk of obesity later in life. Objective: We examined the relation of in utero POPs exposure to offspring obesity and cardiometabolic risk factors at 4 years of age in the Rhea mother–child cohort in Crete, Greece (n = 689). Methods: We determined concentrations of polychlorinated biphenyls (PCBs), dichlorodiphenyldichloroethylene (DDE), and hexachlorobenzene (HCB) in first-trimester maternal serum. We measured child weight, height, waist circumference, skinfold thicknesses, blood pressure (BP), blood levels of lipids, C-reactive protein, and adipokines at 4 years of age. Childhood obesity was defined using age- and sex-specific cut points for body mass index (BMI) as recommended by the International Obesity Task Force. Results: On multivariable regression analyses, a 10-fold increase in HCB was associated with a higher BMI z-score (adjusted β = 0.49; 95% CI: 0.12, 0.86), obesity [relative risk (RR) = 8.14; 95% CI: 1.85, 35.81], abdominal obesity (RR = 3.49; 95% CI: 1.08, 11.28), greater sum of skinfold thickness (β = 7.71 mm; 95% CI: 2.04, 13.39), and higher systolic BP (β = 4.34 mmHg; 95% CI: 0.63, 8.05) at 4 years of age. Prenatal DDE exposure was associated with higher BMI z-score (β = 0.27; 95% CI: 0.04, 0.5), abdominal obesity (RR = 3.76; 95% CI: 1.70, 8.30), and higher diastolic BP (β = 1.79 mmHg; 95% CI: 0.13, 3.46). PCBs were not significantly associated with offspring obesity or cardiometabolic risk factors. Conclusions: Prenatal exposure to DDE and HCB was associated with excess adiposity and higher blood pressure levels in early childhood. Citation: Vafeiadi M, Georgiou V, Chalkiadaki G, Rantakokko P, Kiviranta H, Karachaliou M, Fthenou E, Venihaki M, Sarri K, Vassilaki M, Kyrtopoulos SA, Oken E, Kogevinas M, Chatzi L. 2015. Association of prenatal exposure to persistent organic pollutants with obesity and cardiometabolic traits in early childhood: the Rhea mother–child cohort (Crete, Greece).

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Association of prenatal exposure to persistent organic pollutants with obesity and cardiometabolic traits in early childhood: The rhea mother–child cohort (Crete, Greece)

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