Association of plasma resistin with glomerular filtration rate and albuminuria in hypertensive adults

Allison A. Ellington, A. Rauoof Malik, George G. Klee, Stephen T Turner, Andrew D Rule, Thomas H. Mosley, Iftikhar Jan Kullo

Research output: Contribution to journalArticle

70 Citations (Scopus)

Abstract

Resistin, a recently discovered proinflammatory cytokine, has been variably associated with insulin resistance, inflammation, and renal dysfunction. We investigated the association of plasma resistin with estimated glomerular filtration rate and albuminuria in 1575 hypertensive adults without known coronary heart disease or stroke (857 blacks and 718 non-Hispanic whites). Resistin was measured by a solid phase sandwich immunoassay, estimated glomerular filtration rate was estimated from serum creatinine, and albuminuria was expressed as urine albumin:creatinine ratio. After adjustment for coronary heart disease risk factors (age, sex, body mass index, smoking history, systolic blood pressure, diabetes, and total and high-density lipoprotein cholesterol) and use of renin-angiotensin blockers and statins, higher plasma resistin levels were associated with lower estimated glomerular filtration rate in both ethnic groups (each P<0.0001); the association remained significant after further adjustment for a marker of insulin resistance (homeostasis model assessment for insulin resistance) and a marker of inflammation (plasma C-reactive protein) and was seen in subjects with and without diabetes (each P<0.0001) in both ethnic groups. Higher plasma resistin levels were associated with a higher urine albumin:creatinine ratio in black subjects with diabetes (P<0.0001) and non-Hispanic white subjects with diabetes (P=0.032), independent of coronary heart disease risk factors, hypertension medication use, and statin use; the association remained significant after additional adjustment for homeostasis model assessment for insulin resistance and C-reactive protein. In adults with hypertension, higher circulating resistin levels were associated with a lower estimated glomerular filtration rate and with increased urine albumin:creatinine ratio in the presence of concomitant diabetes. This association was independent of coronary heart disease risk factors and markers of insulin resistance and inflammation.

Original languageEnglish (US)
Pages (from-to)708-714
Number of pages7
JournalHypertension
Volume50
Issue number4
DOIs
StatePublished - Oct 2007

Fingerprint

Resistin
Albuminuria
Glomerular Filtration Rate
Insulin Resistance
Coronary Disease
Creatinine
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Albumins
Urine
Inflammation
Ethnic Groups
C-Reactive Protein
Homeostasis
Blood Pressure
Hypertension
Angiotensins
Immunoassay
Renin
HDL Cholesterol
Blood Proteins

Keywords

  • Albuminuria
  • Glomerular filtration rate
  • Inflammation
  • Insulin resistance
  • Resistin

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Association of plasma resistin with glomerular filtration rate and albuminuria in hypertensive adults. / Ellington, Allison A.; Malik, A. Rauoof; Klee, George G.; Turner, Stephen T; Rule, Andrew D; Mosley, Thomas H.; Kullo, Iftikhar Jan.

In: Hypertension, Vol. 50, No. 4, 10.2007, p. 708-714.

Research output: Contribution to journalArticle

Ellington, Allison A. ; Malik, A. Rauoof ; Klee, George G. ; Turner, Stephen T ; Rule, Andrew D ; Mosley, Thomas H. ; Kullo, Iftikhar Jan. / Association of plasma resistin with glomerular filtration rate and albuminuria in hypertensive adults. In: Hypertension. 2007 ; Vol. 50, No. 4. pp. 708-714.
@article{8cd56b4097cb421aa769221e8ae1bfaa,
title = "Association of plasma resistin with glomerular filtration rate and albuminuria in hypertensive adults",
abstract = "Resistin, a recently discovered proinflammatory cytokine, has been variably associated with insulin resistance, inflammation, and renal dysfunction. We investigated the association of plasma resistin with estimated glomerular filtration rate and albuminuria in 1575 hypertensive adults without known coronary heart disease or stroke (857 blacks and 718 non-Hispanic whites). Resistin was measured by a solid phase sandwich immunoassay, estimated glomerular filtration rate was estimated from serum creatinine, and albuminuria was expressed as urine albumin:creatinine ratio. After adjustment for coronary heart disease risk factors (age, sex, body mass index, smoking history, systolic blood pressure, diabetes, and total and high-density lipoprotein cholesterol) and use of renin-angiotensin blockers and statins, higher plasma resistin levels were associated with lower estimated glomerular filtration rate in both ethnic groups (each P<0.0001); the association remained significant after further adjustment for a marker of insulin resistance (homeostasis model assessment for insulin resistance) and a marker of inflammation (plasma C-reactive protein) and was seen in subjects with and without diabetes (each P<0.0001) in both ethnic groups. Higher plasma resistin levels were associated with a higher urine albumin:creatinine ratio in black subjects with diabetes (P<0.0001) and non-Hispanic white subjects with diabetes (P=0.032), independent of coronary heart disease risk factors, hypertension medication use, and statin use; the association remained significant after additional adjustment for homeostasis model assessment for insulin resistance and C-reactive protein. In adults with hypertension, higher circulating resistin levels were associated with a lower estimated glomerular filtration rate and with increased urine albumin:creatinine ratio in the presence of concomitant diabetes. This association was independent of coronary heart disease risk factors and markers of insulin resistance and inflammation.",
keywords = "Albuminuria, Glomerular filtration rate, Inflammation, Insulin resistance, Resistin",
author = "Ellington, {Allison A.} and Malik, {A. Rauoof} and Klee, {George G.} and Turner, {Stephen T} and Rule, {Andrew D} and Mosley, {Thomas H.} and Kullo, {Iftikhar Jan}",
year = "2007",
month = "10",
doi = "10.1161/HYPERTENSIONAHA.107.095257",
language = "English (US)",
volume = "50",
pages = "708--714",
journal = "Hypertension",
issn = "0194-911X",
publisher = "Lippincott Williams and Wilkins",
number = "4",

}

TY - JOUR

T1 - Association of plasma resistin with glomerular filtration rate and albuminuria in hypertensive adults

AU - Ellington, Allison A.

AU - Malik, A. Rauoof

AU - Klee, George G.

AU - Turner, Stephen T

AU - Rule, Andrew D

AU - Mosley, Thomas H.

AU - Kullo, Iftikhar Jan

PY - 2007/10

Y1 - 2007/10

N2 - Resistin, a recently discovered proinflammatory cytokine, has been variably associated with insulin resistance, inflammation, and renal dysfunction. We investigated the association of plasma resistin with estimated glomerular filtration rate and albuminuria in 1575 hypertensive adults without known coronary heart disease or stroke (857 blacks and 718 non-Hispanic whites). Resistin was measured by a solid phase sandwich immunoassay, estimated glomerular filtration rate was estimated from serum creatinine, and albuminuria was expressed as urine albumin:creatinine ratio. After adjustment for coronary heart disease risk factors (age, sex, body mass index, smoking history, systolic blood pressure, diabetes, and total and high-density lipoprotein cholesterol) and use of renin-angiotensin blockers and statins, higher plasma resistin levels were associated with lower estimated glomerular filtration rate in both ethnic groups (each P<0.0001); the association remained significant after further adjustment for a marker of insulin resistance (homeostasis model assessment for insulin resistance) and a marker of inflammation (plasma C-reactive protein) and was seen in subjects with and without diabetes (each P<0.0001) in both ethnic groups. Higher plasma resistin levels were associated with a higher urine albumin:creatinine ratio in black subjects with diabetes (P<0.0001) and non-Hispanic white subjects with diabetes (P=0.032), independent of coronary heart disease risk factors, hypertension medication use, and statin use; the association remained significant after additional adjustment for homeostasis model assessment for insulin resistance and C-reactive protein. In adults with hypertension, higher circulating resistin levels were associated with a lower estimated glomerular filtration rate and with increased urine albumin:creatinine ratio in the presence of concomitant diabetes. This association was independent of coronary heart disease risk factors and markers of insulin resistance and inflammation.

AB - Resistin, a recently discovered proinflammatory cytokine, has been variably associated with insulin resistance, inflammation, and renal dysfunction. We investigated the association of plasma resistin with estimated glomerular filtration rate and albuminuria in 1575 hypertensive adults without known coronary heart disease or stroke (857 blacks and 718 non-Hispanic whites). Resistin was measured by a solid phase sandwich immunoassay, estimated glomerular filtration rate was estimated from serum creatinine, and albuminuria was expressed as urine albumin:creatinine ratio. After adjustment for coronary heart disease risk factors (age, sex, body mass index, smoking history, systolic blood pressure, diabetes, and total and high-density lipoprotein cholesterol) and use of renin-angiotensin blockers and statins, higher plasma resistin levels were associated with lower estimated glomerular filtration rate in both ethnic groups (each P<0.0001); the association remained significant after further adjustment for a marker of insulin resistance (homeostasis model assessment for insulin resistance) and a marker of inflammation (plasma C-reactive protein) and was seen in subjects with and without diabetes (each P<0.0001) in both ethnic groups. Higher plasma resistin levels were associated with a higher urine albumin:creatinine ratio in black subjects with diabetes (P<0.0001) and non-Hispanic white subjects with diabetes (P=0.032), independent of coronary heart disease risk factors, hypertension medication use, and statin use; the association remained significant after additional adjustment for homeostasis model assessment for insulin resistance and C-reactive protein. In adults with hypertension, higher circulating resistin levels were associated with a lower estimated glomerular filtration rate and with increased urine albumin:creatinine ratio in the presence of concomitant diabetes. This association was independent of coronary heart disease risk factors and markers of insulin resistance and inflammation.

KW - Albuminuria

KW - Glomerular filtration rate

KW - Inflammation

KW - Insulin resistance

KW - Resistin

UR - http://www.scopus.com/inward/record.url?scp=34548853985&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34548853985&partnerID=8YFLogxK

U2 - 10.1161/HYPERTENSIONAHA.107.095257

DO - 10.1161/HYPERTENSIONAHA.107.095257

M3 - Article

C2 - 17785630

AN - SCOPUS:34548853985

VL - 50

SP - 708

EP - 714

JO - Hypertension

JF - Hypertension

SN - 0194-911X

IS - 4

ER -