Association of parity and time since last birth with breast cancer prognosis by intrinsic subtype

Xuezheng Sun, Hazel B. Nichols, Chiu Kit Tse, Mary B. Bell, Whitney R. Robinson, Mark E. Sherman, Andrew F. Olshan, Melissa A. Troester

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Background: Parity and time since last birth influence breast cancer risk and vary by intrinsic tumor subtype, but the independent effects of these factors on prognosis have received limited attention. Methods: Study participants were 1,140 invasive breast cancer patients from phases I and II of the population-based Carolina Breast Cancer Study, with tissue blocks available for subtyping using immunohistochemical markers. Breast cancer risk factors, including pregnancy history, were collected via in-person interviews administered shortly after diagnosis. Vital status was determined using the National Death Index. The association of parity and birth recency with breast cancer-specific and overall survival was assessed using Cox proportional hazards models. Results: During follow-up (median = 13.5 years), 450 patients died, 61% due to breast cancer (n = 276). High parity (3+ births) and recent birth (<5 years before diagnosis) were positively associated with breast cancer-specific mortality, independent of age, race, and selected socioeconomic factors [parity, reference = nulliparous, adjusted HR = 1.76; 95% confidence interval (CI) = 1.13-2.73; birth recency, reference = 10+ years, adjusted HR = 1.29; 95% CI, 0.79-2.11]. The associations were stronger among patients with luminal tumors and those surviving longer than 5 years. Conclusions: Parity and recent birth are associated with worse survival among breast cancer patients, particularly among luminal breast cancers and long-term survivors. Impact: The biologic effects of parity and birth recency may extend from etiology to tumor promotion and progression.

Original languageEnglish (US)
Pages (from-to)60-67
Number of pages8
JournalCancer Epidemiology Biomarkers and Prevention
Volume25
Issue number1
DOIs
StatePublished - Jan 1 2016

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Parity
Parturition
Breast Neoplasms
Confidence Intervals
Neoplasms
Reproductive History
Survival
Proportional Hazards Models
Survivors
Interviews
Mortality
Population

ASJC Scopus subject areas

  • Epidemiology
  • Oncology

Cite this

Association of parity and time since last birth with breast cancer prognosis by intrinsic subtype. / Sun, Xuezheng; Nichols, Hazel B.; Tse, Chiu Kit; Bell, Mary B.; Robinson, Whitney R.; Sherman, Mark E.; Olshan, Andrew F.; Troester, Melissa A.

In: Cancer Epidemiology Biomarkers and Prevention, Vol. 25, No. 1, 01.01.2016, p. 60-67.

Research output: Contribution to journalArticle

Sun, Xuezheng ; Nichols, Hazel B. ; Tse, Chiu Kit ; Bell, Mary B. ; Robinson, Whitney R. ; Sherman, Mark E. ; Olshan, Andrew F. ; Troester, Melissa A. / Association of parity and time since last birth with breast cancer prognosis by intrinsic subtype. In: Cancer Epidemiology Biomarkers and Prevention. 2016 ; Vol. 25, No. 1. pp. 60-67.
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abstract = "Background: Parity and time since last birth influence breast cancer risk and vary by intrinsic tumor subtype, but the independent effects of these factors on prognosis have received limited attention. Methods: Study participants were 1,140 invasive breast cancer patients from phases I and II of the population-based Carolina Breast Cancer Study, with tissue blocks available for subtyping using immunohistochemical markers. Breast cancer risk factors, including pregnancy history, were collected via in-person interviews administered shortly after diagnosis. Vital status was determined using the National Death Index. The association of parity and birth recency with breast cancer-specific and overall survival was assessed using Cox proportional hazards models. Results: During follow-up (median = 13.5 years), 450 patients died, 61{\%} due to breast cancer (n = 276). High parity (3+ births) and recent birth (<5 years before diagnosis) were positively associated with breast cancer-specific mortality, independent of age, race, and selected socioeconomic factors [parity, reference = nulliparous, adjusted HR = 1.76; 95{\%} confidence interval (CI) = 1.13-2.73; birth recency, reference = 10+ years, adjusted HR = 1.29; 95{\%} CI, 0.79-2.11]. The associations were stronger among patients with luminal tumors and those surviving longer than 5 years. Conclusions: Parity and recent birth are associated with worse survival among breast cancer patients, particularly among luminal breast cancers and long-term survivors. Impact: The biologic effects of parity and birth recency may extend from etiology to tumor promotion and progression.",
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