Association of Ovary-Sparing Hysterectomy With Ovarian Reserve

Emanuel C. Trabuco, Patricia G. Moorman, Alicia Algeciras-Schimnich, Amy L. Weaver, William Arthur Cliby

Research output: Contribution to journalArticle

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Abstract

OBJECTIVE:: To evaluate the association of hysterectomy on ovarian function by comparing antimüllerian hormone, a marker of ovarian reserve, before and after hysterectomy. METHODS:: The Prospective Research on Ovarian Function study prospectively followed 1) premenopausal women undergoing ovary-sparing hysterectomy for benign indications, and 2) a referent cohort with similar age distributions and intact reproductive organs; they reported that women undergoing hysterectomy became menopausal 1.9 years earlier than referents. In a planned secondary analysis, baseline antimüllerian hormone levels and the absolute change and percentage change in antimüllerian hormone levels between baseline and 1-year follow-up were compared between groups. RESULTS:: Baseline median antimüllerian hormone levels were similar between the hysterectomy group (n=148) and the referent group (n=172). After 1 year, patients undergoing hysterectomy had a significantly greater median percentage decrease (−40.7% compared with −20.9%; P

Original languageEnglish (US)
JournalObstetrics and Gynecology
DOIs
StateAccepted/In press - Apr 4 2016

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ASJC Scopus subject areas

  • Obstetrics and Gynecology

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