TY - JOUR
T1 - Association of newer diastolic function parameters with age in healthy subjects
T2 - A population-based study
AU - Munagala, Vijaya K.
AU - Jacobsen, Steven J.
AU - Mahoney, Douglas W.
AU - Rodeheffer, Richard J.
AU - Bailey, Kent R.
AU - Redfield, Margaret M.
N1 - Funding Information:
Supported by grants from the Public Health Service (NIH HL 55502 and NIH AR 30582), the Marriott Foundation, the Miami Heart Research Institute and the Mayo Foundation.
PY - 2003/10/1
Y1 - 2003/10/1
N2 - Objectives: We sought to determine if newer Doppler diastolic function parameters are associated with age and to define age-stratified reference ranges for these parameters in a population-based setting. Background: Although newer Doppler parameters aid in the evaluation of diastolic function and filling pressures, age-specific reference ranges are poorly described. Methods: Randomly selected residents of Olmsted County, Minn, age ≥ 45 years were studied (n = 2042) prospectively. Those without a history of cardiovascular disease or abnormal 2-dimensional echocardiograms were selected. Measured parameters included the transmitral early (E) and late (A) filling velocities at rest and with Valsalva, A duration, pulmonary venous atrial reversal duration, lateral and septal early diastolic mitral annular velocities, E/lateral early diastolic mitral annular velocity, E/septal early diastolic mitral annular velocity, and the index of left ventricular myocardial performance. Results: A total of 1012 subjects met the inclusion criteria. Both A duration (r = 0.18, P < .001) and pulmonary venous atrial reversal duration (r = 0.28, P < .001) were longer in older subjects, whereas their difference showed a marginal correlation with age (r = 0.07, P = .036). The E/A ratio at peak Valsalva correlated with age (r = -0.54, P < .001) whereas the change in E/A with Valsalva (corrected for E-A fusion) showed a marginal correlation with age (r = 0.08, P = .032). Both E/lateral early diastolic mitral annular velocity (r = 0.39, P < .001) and E/septal early diastolic mitral annular velocity (r = 0.27, P < .001) increased with age. Left ventricular myocardial performance showed a marginal correlation with age (r = 0.08, P = .014). Age specific reference ranges (median, 5th and 95th percentiles) for all parameters are provided. Conclusions: All newer Doppler diastolic function parameters showed a variable but significant correlation with age. Age-specific reference values will aid in the interpretation of diastolic function parameters.
AB - Objectives: We sought to determine if newer Doppler diastolic function parameters are associated with age and to define age-stratified reference ranges for these parameters in a population-based setting. Background: Although newer Doppler parameters aid in the evaluation of diastolic function and filling pressures, age-specific reference ranges are poorly described. Methods: Randomly selected residents of Olmsted County, Minn, age ≥ 45 years were studied (n = 2042) prospectively. Those without a history of cardiovascular disease or abnormal 2-dimensional echocardiograms were selected. Measured parameters included the transmitral early (E) and late (A) filling velocities at rest and with Valsalva, A duration, pulmonary venous atrial reversal duration, lateral and septal early diastolic mitral annular velocities, E/lateral early diastolic mitral annular velocity, E/septal early diastolic mitral annular velocity, and the index of left ventricular myocardial performance. Results: A total of 1012 subjects met the inclusion criteria. Both A duration (r = 0.18, P < .001) and pulmonary venous atrial reversal duration (r = 0.28, P < .001) were longer in older subjects, whereas their difference showed a marginal correlation with age (r = 0.07, P = .036). The E/A ratio at peak Valsalva correlated with age (r = -0.54, P < .001) whereas the change in E/A with Valsalva (corrected for E-A fusion) showed a marginal correlation with age (r = 0.08, P = .032). Both E/lateral early diastolic mitral annular velocity (r = 0.39, P < .001) and E/septal early diastolic mitral annular velocity (r = 0.27, P < .001) increased with age. Left ventricular myocardial performance showed a marginal correlation with age (r = 0.08, P = .014). Age specific reference ranges (median, 5th and 95th percentiles) for all parameters are provided. Conclusions: All newer Doppler diastolic function parameters showed a variable but significant correlation with age. Age-specific reference values will aid in the interpretation of diastolic function parameters.
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U2 - 10.1016/S0894-7317(03)00516-9
DO - 10.1016/S0894-7317(03)00516-9
M3 - Article
C2 - 14566298
AN - SCOPUS:0141640986
SN - 0894-7317
VL - 16
SP - 1049
EP - 1056
JO - Journal of the American Society of Echocardiography
JF - Journal of the American Society of Echocardiography
IS - 10
ER -