Association of newer diastolic function parameters with age in healthy subjects

A population-based study

Vijaya K. Munagala, Steven J. Jacobsen, Douglas W. Mahoney, Richard J. Rodeheffer, Kent R Bailey, Margaret May Redfield

Research output: Contribution to journalArticle

126 Citations (Scopus)

Abstract

Objectives: We sought to determine if newer Doppler diastolic function parameters are associated with age and to define age-stratified reference ranges for these parameters in a population-based setting. Background: Although newer Doppler parameters aid in the evaluation of diastolic function and filling pressures, age-specific reference ranges are poorly described. Methods: Randomly selected residents of Olmsted County, Minn, age ≥ 45 years were studied (n = 2042) prospectively. Those without a history of cardiovascular disease or abnormal 2-dimensional echocardiograms were selected. Measured parameters included the transmitral early (E) and late (A) filling velocities at rest and with Valsalva, A duration, pulmonary venous atrial reversal duration, lateral and septal early diastolic mitral annular velocities, E/lateral early diastolic mitral annular velocity, E/septal early diastolic mitral annular velocity, and the index of left ventricular myocardial performance. Results: A total of 1012 subjects met the inclusion criteria. Both A duration (r = 0.18, P < .001) and pulmonary venous atrial reversal duration (r = 0.28, P < .001) were longer in older subjects, whereas their difference showed a marginal correlation with age (r = 0.07, P = .036). The E/A ratio at peak Valsalva correlated with age (r = -0.54, P < .001) whereas the change in E/A with Valsalva (corrected for E-A fusion) showed a marginal correlation with age (r = 0.08, P = .032). Both E/lateral early diastolic mitral annular velocity (r = 0.39, P < .001) and E/septal early diastolic mitral annular velocity (r = 0.27, P < .001) increased with age. Left ventricular myocardial performance showed a marginal correlation with age (r = 0.08, P = .014). Age specific reference ranges (median, 5th and 95th percentiles) for all parameters are provided. Conclusions: All newer Doppler diastolic function parameters showed a variable but significant correlation with age. Age-specific reference values will aid in the interpretation of diastolic function parameters.

Original languageEnglish (US)
Pages (from-to)1049-1056
Number of pages8
JournalJournal of the American Society of Echocardiography
Volume16
Issue number10
DOIs
StatePublished - Oct 1 2003

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Healthy Volunteers
Reference Values
Population
Lung
Cardiovascular Diseases
Pressure

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Radiology Nuclear Medicine and imaging

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Association of newer diastolic function parameters with age in healthy subjects : A population-based study. / Munagala, Vijaya K.; Jacobsen, Steven J.; Mahoney, Douglas W.; Rodeheffer, Richard J.; Bailey, Kent R; Redfield, Margaret May.

In: Journal of the American Society of Echocardiography, Vol. 16, No. 10, 01.10.2003, p. 1049-1056.

Research output: Contribution to journalArticle

Munagala, Vijaya K. ; Jacobsen, Steven J. ; Mahoney, Douglas W. ; Rodeheffer, Richard J. ; Bailey, Kent R ; Redfield, Margaret May. / Association of newer diastolic function parameters with age in healthy subjects : A population-based study. In: Journal of the American Society of Echocardiography. 2003 ; Vol. 16, No. 10. pp. 1049-1056.
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abstract = "Objectives: We sought to determine if newer Doppler diastolic function parameters are associated with age and to define age-stratified reference ranges for these parameters in a population-based setting. Background: Although newer Doppler parameters aid in the evaluation of diastolic function and filling pressures, age-specific reference ranges are poorly described. Methods: Randomly selected residents of Olmsted County, Minn, age ≥ 45 years were studied (n = 2042) prospectively. Those without a history of cardiovascular disease or abnormal 2-dimensional echocardiograms were selected. Measured parameters included the transmitral early (E) and late (A) filling velocities at rest and with Valsalva, A duration, pulmonary venous atrial reversal duration, lateral and septal early diastolic mitral annular velocities, E/lateral early diastolic mitral annular velocity, E/septal early diastolic mitral annular velocity, and the index of left ventricular myocardial performance. Results: A total of 1012 subjects met the inclusion criteria. Both A duration (r = 0.18, P < .001) and pulmonary venous atrial reversal duration (r = 0.28, P < .001) were longer in older subjects, whereas their difference showed a marginal correlation with age (r = 0.07, P = .036). The E/A ratio at peak Valsalva correlated with age (r = -0.54, P < .001) whereas the change in E/A with Valsalva (corrected for E-A fusion) showed a marginal correlation with age (r = 0.08, P = .032). Both E/lateral early diastolic mitral annular velocity (r = 0.39, P < .001) and E/septal early diastolic mitral annular velocity (r = 0.27, P < .001) increased with age. Left ventricular myocardial performance showed a marginal correlation with age (r = 0.08, P = .014). Age specific reference ranges (median, 5th and 95th percentiles) for all parameters are provided. Conclusions: All newer Doppler diastolic function parameters showed a variable but significant correlation with age. Age-specific reference values will aid in the interpretation of diastolic function parameters.",
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T2 - A population-based study

AU - Munagala, Vijaya K.

AU - Jacobsen, Steven J.

AU - Mahoney, Douglas W.

AU - Rodeheffer, Richard J.

AU - Bailey, Kent R

AU - Redfield, Margaret May

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N2 - Objectives: We sought to determine if newer Doppler diastolic function parameters are associated with age and to define age-stratified reference ranges for these parameters in a population-based setting. Background: Although newer Doppler parameters aid in the evaluation of diastolic function and filling pressures, age-specific reference ranges are poorly described. Methods: Randomly selected residents of Olmsted County, Minn, age ≥ 45 years were studied (n = 2042) prospectively. Those without a history of cardiovascular disease or abnormal 2-dimensional echocardiograms were selected. Measured parameters included the transmitral early (E) and late (A) filling velocities at rest and with Valsalva, A duration, pulmonary venous atrial reversal duration, lateral and septal early diastolic mitral annular velocities, E/lateral early diastolic mitral annular velocity, E/septal early diastolic mitral annular velocity, and the index of left ventricular myocardial performance. Results: A total of 1012 subjects met the inclusion criteria. Both A duration (r = 0.18, P < .001) and pulmonary venous atrial reversal duration (r = 0.28, P < .001) were longer in older subjects, whereas their difference showed a marginal correlation with age (r = 0.07, P = .036). The E/A ratio at peak Valsalva correlated with age (r = -0.54, P < .001) whereas the change in E/A with Valsalva (corrected for E-A fusion) showed a marginal correlation with age (r = 0.08, P = .032). Both E/lateral early diastolic mitral annular velocity (r = 0.39, P < .001) and E/septal early diastolic mitral annular velocity (r = 0.27, P < .001) increased with age. Left ventricular myocardial performance showed a marginal correlation with age (r = 0.08, P = .014). Age specific reference ranges (median, 5th and 95th percentiles) for all parameters are provided. Conclusions: All newer Doppler diastolic function parameters showed a variable but significant correlation with age. Age-specific reference values will aid in the interpretation of diastolic function parameters.

AB - Objectives: We sought to determine if newer Doppler diastolic function parameters are associated with age and to define age-stratified reference ranges for these parameters in a population-based setting. Background: Although newer Doppler parameters aid in the evaluation of diastolic function and filling pressures, age-specific reference ranges are poorly described. Methods: Randomly selected residents of Olmsted County, Minn, age ≥ 45 years were studied (n = 2042) prospectively. Those without a history of cardiovascular disease or abnormal 2-dimensional echocardiograms were selected. Measured parameters included the transmitral early (E) and late (A) filling velocities at rest and with Valsalva, A duration, pulmonary venous atrial reversal duration, lateral and septal early diastolic mitral annular velocities, E/lateral early diastolic mitral annular velocity, E/septal early diastolic mitral annular velocity, and the index of left ventricular myocardial performance. Results: A total of 1012 subjects met the inclusion criteria. Both A duration (r = 0.18, P < .001) and pulmonary venous atrial reversal duration (r = 0.28, P < .001) were longer in older subjects, whereas their difference showed a marginal correlation with age (r = 0.07, P = .036). The E/A ratio at peak Valsalva correlated with age (r = -0.54, P < .001) whereas the change in E/A with Valsalva (corrected for E-A fusion) showed a marginal correlation with age (r = 0.08, P = .032). Both E/lateral early diastolic mitral annular velocity (r = 0.39, P < .001) and E/septal early diastolic mitral annular velocity (r = 0.27, P < .001) increased with age. Left ventricular myocardial performance showed a marginal correlation with age (r = 0.08, P = .014). Age specific reference ranges (median, 5th and 95th percentiles) for all parameters are provided. Conclusions: All newer Doppler diastolic function parameters showed a variable but significant correlation with age. Age-specific reference values will aid in the interpretation of diastolic function parameters.

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