Association of N-type calcium channel autoimmunity in patients with autoimmune autonomic ganglionopathy

Kurt Kimpinski; Valeria Iodice; Steve Vernino; Paola Sandroni; Phillip A. Low

doi:10.1016/j.autneu.2009.06.002

Association of N-type calcium channel autoimmunity in patients with autoimmune autonomic ganglionopathy

Kurt Kimpinski, Valeria Iodice, Steve Vernino, Paola Sandroni, Phillip A. Low

Neurology

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Abstract

The nicotinic acetylcholine receptor (nAChR) antibody directly contributes to the autonomic dysfunction in Autoimmune Autonomic Ganglionopathy (AAG). The pathological mechanism leading to autonomic dysfunction in seronegative AAG is unclear. We evaluated patients with presumed antibody negative AAG (n = 49) to determine whether there was an association with other autoantibodies. Three patients met the clinical criteria and were positive for N-type calcium channel antibodies. All patients had severe autonomic dysfunction characterized by orthostatic hypotension and gastrointestinal involvement. Autonomic testing revealed severe impairment of sudomotor, cardiovagal, and adrenergic domains. These findings raise the possibility that other autoantibodies may contribute to the pathogenesis of AAG.

Original language	English (US)
Pages (from-to)	136-139
Number of pages	4
Journal	Autonomic Neuroscience: Basic and Clinical
Volume	150
Issue number	1-2
DOIs	https://doi.org/10.1016/j.autneu.2009.06.002
State	Published - Oct 5 2009

Keywords

Autoimmune ganglionopathy
Autonomic failure
Calcium channel antibodies

ASJC Scopus subject areas

Endocrine and Autonomic Systems
Clinical Neurology
Cellular and Molecular Neuroscience

Access to Document

10.1016/j.autneu.2009.06.002

Cite this

@article{1e827e6dc2584e82a03e4d772240e62b,

title = "Association of N-type calcium channel autoimmunity in patients with autoimmune autonomic ganglionopathy",

abstract = "The nicotinic acetylcholine receptor (nAChR) antibody directly contributes to the autonomic dysfunction in Autoimmune Autonomic Ganglionopathy (AAG). The pathological mechanism leading to autonomic dysfunction in seronegative AAG is unclear. We evaluated patients with presumed antibody negative AAG (n = 49) to determine whether there was an association with other autoantibodies. Three patients met the clinical criteria and were positive for N-type calcium channel antibodies. All patients had severe autonomic dysfunction characterized by orthostatic hypotension and gastrointestinal involvement. Autonomic testing revealed severe impairment of sudomotor, cardiovagal, and adrenergic domains. These findings raise the possibility that other autoantibodies may contribute to the pathogenesis of AAG.",

keywords = "Autoimmune ganglionopathy, Autonomic failure, Calcium channel antibodies",

author = "Kurt Kimpinski and Valeria Iodice and Steve Vernino and Paola Sandroni and Low, {Phillip A.}",

note = "Funding Information: This work was supported in part by National Institutes of Health (NS 32352, NS 44233, NS 22352, NS 43364), Mayo CTSA (UL1 RR24150), and Mayo Funds. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institute of Neurological Disorders and Stroke or the National Institutes of Health.",

year = "2009",

month = oct,

day = "5",

doi = "10.1016/j.autneu.2009.06.002",

language = "English (US)",

volume = "150",

pages = "136--139",

journal = "Autonomic Neuroscience: Basic and Clinical",

issn = "1566-0702",

publisher = "Elsevier",

number = "1-2",

}

TY - JOUR

T1 - Association of N-type calcium channel autoimmunity in patients with autoimmune autonomic ganglionopathy

AU - Kimpinski, Kurt

AU - Iodice, Valeria

AU - Vernino, Steve

AU - Sandroni, Paola

AU - Low, Phillip A.

N1 - Funding Information: This work was supported in part by National Institutes of Health (NS 32352, NS 44233, NS 22352, NS 43364), Mayo CTSA (UL1 RR24150), and Mayo Funds. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institute of Neurological Disorders and Stroke or the National Institutes of Health.

PY - 2009/10/5

Y1 - 2009/10/5

N2 - The nicotinic acetylcholine receptor (nAChR) antibody directly contributes to the autonomic dysfunction in Autoimmune Autonomic Ganglionopathy (AAG). The pathological mechanism leading to autonomic dysfunction in seronegative AAG is unclear. We evaluated patients with presumed antibody negative AAG (n = 49) to determine whether there was an association with other autoantibodies. Three patients met the clinical criteria and were positive for N-type calcium channel antibodies. All patients had severe autonomic dysfunction characterized by orthostatic hypotension and gastrointestinal involvement. Autonomic testing revealed severe impairment of sudomotor, cardiovagal, and adrenergic domains. These findings raise the possibility that other autoantibodies may contribute to the pathogenesis of AAG.

AB - The nicotinic acetylcholine receptor (nAChR) antibody directly contributes to the autonomic dysfunction in Autoimmune Autonomic Ganglionopathy (AAG). The pathological mechanism leading to autonomic dysfunction in seronegative AAG is unclear. We evaluated patients with presumed antibody negative AAG (n = 49) to determine whether there was an association with other autoantibodies. Three patients met the clinical criteria and were positive for N-type calcium channel antibodies. All patients had severe autonomic dysfunction characterized by orthostatic hypotension and gastrointestinal involvement. Autonomic testing revealed severe impairment of sudomotor, cardiovagal, and adrenergic domains. These findings raise the possibility that other autoantibodies may contribute to the pathogenesis of AAG.

KW - Autoimmune ganglionopathy

KW - Autonomic failure

KW - Calcium channel antibodies

UR - http://www.scopus.com/inward/record.url?scp=69349095704&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=69349095704&partnerID=8YFLogxK

U2 - 10.1016/j.autneu.2009.06.002

DO - 10.1016/j.autneu.2009.06.002

M3 - Article

C2 - 19541551

AN - SCOPUS:69349095704

SN - 1566-0702

VL - 150

SP - 136

EP - 139

JO - Autonomic Neuroscience: Basic and Clinical

JF - Autonomic Neuroscience: Basic and Clinical

IS - 1-2

ER -

Association of N-type calcium channel autoimmunity in patients with autoimmune autonomic ganglionopathy

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this