Association of midlife lipids with 20-year cognitive change: A cohort study

Melinda C. Power, Andreea Rawlings, A. Richey Sharrett, Karen Bandeen-Roche, Josef Coresh, Christie M. Ballantyne, Yashashwi Pokharel, Erin D. Michos, Alan Penman, Alvaro Alonso, David Knopman, Thomas H. Mosley, Rebecca F. Gottesman

Research output: Contribution to journalArticle

22 Scopus citations

Abstract

Introduction Existing studies predominantly consider the association of late-life lipid levels and subsequent cognitive change. However, midlife rather than late-life risk factors are often most relevant to cognitive health. Methods We quantified the association between measured serum lipids in midlife and subsequent 20-year change in performance on three cognitive tests in 13,997 participants of the Atherosclerosis Risk in Communities study. Results Elevated total cholesterol, low-density lipoprotein cholesterol, and triglycerides were associated with greater 20-year decline on a test of executive function, sustained attention, and processing speed. Higher total cholesterol and triglycerides were also associated with greater 20-year decline in memory scores and a measure summarizing performance on all three tests. High-density lipoprotein cholesterol was not associated with cognitive change. Results were materially unchanged in sensitivity analyses addressing informative missingness. Discussion Elevated total cholesterol, low-density lipoprotein cholesterol, and triglycerides in midlife were associated with greater 20-year cognitive decline.

Original languageEnglish (US)
Pages (from-to)167-177
Number of pages11
JournalAlzheimer's and Dementia
Volume14
Issue number2
DOIs
StatePublished - Feb 2018

Keywords

  • Cholesterol
  • Cognition
  • Cognitive change
  • Cognitive decline
  • Cohort
  • Dementia
  • Epidemiology
  • Lipids
  • Longitudinal

ASJC Scopus subject areas

  • Epidemiology
  • Health Policy
  • Developmental Neuroscience
  • Clinical Neurology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health
  • Cellular and Molecular Neuroscience

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    Power, M. C., Rawlings, A., Sharrett, A. R., Bandeen-Roche, K., Coresh, J., Ballantyne, C. M., Pokharel, Y., Michos, E. D., Penman, A., Alonso, A., Knopman, D., Mosley, T. H., & Gottesman, R. F. (2018). Association of midlife lipids with 20-year cognitive change: A cohort study. Alzheimer's and Dementia, 14(2), 167-177. https://doi.org/10.1016/j.jalz.2017.07.757