TY - JOUR
T1 - Association of metabolic health phenotypes, obesity, and hepatocellular carcinoma risk
AU - Nasereldin, Duaa S.
AU - White, Launia J.
AU - Hodge, David O.
AU - Roberts, Lewis R.
AU - Patel, Tushar
AU - Antwi, Samuel O.
N1 - Funding Information:
The study is supported by funding from the National Cancer Institute (K01 CA237875) to S.O. Antwi. D.S. Nasereldin wrote the first draft of the article. L.J. White and D.O. Hodge performed statistical analyses. L.R. Roberts and T. Patel critically revised the manuscript for important intellectual content. S.O. Antwi is originator of the concept and design of the study, performed extensive editing of the initial draft and supervised the study. All authors have approved the final version submitted. The data may be made available to researchers upon request to, and approval by, the Rochester Epidemiology Project ( https://rochesterproject.org/).
Funding Information:
The study is supported by funding from the National Cancer Institute (K01 CA237875) to S.O. Antwi.
Publisher Copyright:
© 2021
PY - 2022/7
Y1 - 2022/7
N2 - Background: The obesity and hepatocellular carcinoma (HCC) risk association may differ by individuals’ metabolic health status. Aim: To investigate the association between obesity categories and HCC risk among individuals with different metabolic health phenotypes. Methods: A case-control study among 518 HCC cases and 1,036 frequency-matched controls was conducted. Body mass index (BMI) was assessed before diagnosis. Pre-diagnosis data on dyslipidemia, hypertension, and diabetes were used to categorize participants as metabolically healthy or metabolically unhealthy. Participants were further categorized into metabolically healthy normal weight (MHNW), metabolically healthy overweight (MHOW), metabolically healthy obese (MHO), metabolically unhealthy normal weight (MUNW), metabolically unhealthy overweight (MUOW), and metabolically unhealthy obese (MHO). We used logistic regression to calculate multivariable-adjusted odds ratios (ORs) and 95% confidence intervals (CIs). Results: Being overweight (OR=1.68, 95%CI=1.21–2.34) or obese (OR=1.49, 95%CI=1.11–1.89) was associated with higher HCC risk. Among metabolically healthy participants, no association was found between being overweight or obese and HCC risk. However, among the metabolically unhealthy participants, being overweight (OR=1.89, 95%CI=1.31–2.72) or obese (OR=1.50, 95%CI=1.07–2.09) was associated with higher HCC risk. Compared to the MHNW phenotype, no association was found between the MHOW and MHO phenotypes and HCC risk, but the MUNW (OR=1.94, 95%CI=1.09–3.43), MUOW (OR=3.78, 95%CI=2.15–6.65), and MUO (OR=2.93, 95%CI=1.70–5.05) phenotypes were associated with higher HCC risk. Conclusion: The association between BMI and HCC appears to be restricted to individuals with underlying metabolic abnormalities.
AB - Background: The obesity and hepatocellular carcinoma (HCC) risk association may differ by individuals’ metabolic health status. Aim: To investigate the association between obesity categories and HCC risk among individuals with different metabolic health phenotypes. Methods: A case-control study among 518 HCC cases and 1,036 frequency-matched controls was conducted. Body mass index (BMI) was assessed before diagnosis. Pre-diagnosis data on dyslipidemia, hypertension, and diabetes were used to categorize participants as metabolically healthy or metabolically unhealthy. Participants were further categorized into metabolically healthy normal weight (MHNW), metabolically healthy overweight (MHOW), metabolically healthy obese (MHO), metabolically unhealthy normal weight (MUNW), metabolically unhealthy overweight (MUOW), and metabolically unhealthy obese (MHO). We used logistic regression to calculate multivariable-adjusted odds ratios (ORs) and 95% confidence intervals (CIs). Results: Being overweight (OR=1.68, 95%CI=1.21–2.34) or obese (OR=1.49, 95%CI=1.11–1.89) was associated with higher HCC risk. Among metabolically healthy participants, no association was found between being overweight or obese and HCC risk. However, among the metabolically unhealthy participants, being overweight (OR=1.89, 95%CI=1.31–2.72) or obese (OR=1.50, 95%CI=1.07–2.09) was associated with higher HCC risk. Compared to the MHNW phenotype, no association was found between the MHOW and MHO phenotypes and HCC risk, but the MUNW (OR=1.94, 95%CI=1.09–3.43), MUOW (OR=3.78, 95%CI=2.15–6.65), and MUO (OR=2.93, 95%CI=1.70–5.05) phenotypes were associated with higher HCC risk. Conclusion: The association between BMI and HCC appears to be restricted to individuals with underlying metabolic abnormalities.
KW - BMI
KW - HCC
KW - Hepatocellular carcinoma
KW - Liver cancer
KW - Metabolic
KW - obesity
UR - http://www.scopus.com/inward/record.url?scp=85121749599&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85121749599&partnerID=8YFLogxK
U2 - 10.1016/j.dld.2021.12.002
DO - 10.1016/j.dld.2021.12.002
M3 - Article
C2 - 34953761
AN - SCOPUS:85121749599
SN - 1590-8658
VL - 54
SP - 964
EP - 972
JO - Digestive and Liver Disease
JF - Digestive and Liver Disease
IS - 7
ER -