Association of integrin α2 gene variants with ischemic stroke

Mar Matarin, W. Mark Brown, John A. Hardy, Stephen S. Rich, Andrew B. Singleton, Robert D. Brown, Thomas G. Brott, Bradford B. Worrall, James F. Meschia

Research output: Contribution to journalArticle

26 Scopus citations

Abstract

Genetic variants in the gene encoding integrin α2 (ITGA2) have been reported to be associated with an increased risk for ischemic stroke. The purpose of this study was to investigate the association between haplotype-tagging single-nucleotide polymorphisms (tSNPs) in ITGA2 and risk of ischemic stroke in a collection of North American stroke cases and controls. The study included 484 cases and 263 controls. Thirteen tSNPs were genotyped. Association tests at and across each tSNP were performed, including haplotype association analysis. Secondary analyses considered stroke subtypes on the basis of Trial of Org 10172 in Acute Stroke Treatment (TOAST) criteria. We observed significant association between tSNP rs3756541 (additive model, odds ratio (OR), 1.49; 95% confidence interval (CI), 1.11 to 2.04; P=0.009) and disease and a trend toward association at rs2303124 (recessive model, OR, 1.56; 95% CI, 1.05 to 2.33; P=0.03). These associations remained significant in the haplotype analyses. The associated tSNPs did not distinguish stroke etiology after application of TOAST criteria. Our results suggest that genetic variability within ITGA2 may confer risk for ischemic stroke independent of conventional risk factors. These results provide additional support for a role for platelet receptor genes in the pathogenesis of ischemic stroke of diverse subtypes.

Original languageEnglish (US)
Pages (from-to)81-89
Number of pages9
JournalJournal of Cerebral Blood Flow and Metabolism
Volume28
Issue number1
DOIs
StatePublished - Jan 2008

Keywords

  • Atherosclerosis
  • Cerebral infarction
  • Genetics
  • Integrin α2
  • Stroke

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine

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