TY - JOUR
T1 - Association of health-related quality of life with gender in patients with B-cell chronic lymphocytic leukemia
AU - Pashos, Chris L.
AU - Flowers, Christopher R.
AU - Kay, Neil E.
AU - Weiss, Mark
AU - Lamanna, Nicole
AU - Farber, Charles
AU - Lerner, Susan
AU - Sharman, Jeff
AU - Grinblatt, David
AU - Flinn, Ian W.
AU - Kozloff, Mark
AU - Swern, Arlene S.
AU - Street, Thomas K.
AU - Sullivan, Kristen A.
AU - Harding, Gale
AU - Khan, Zeba M.
N1 - Funding Information:
Conflict of interest The authors had full control of all primary data and agree to allow the journal to review the data if requested. Farber, Flinn, Flowers, Grinblatt, Kay, Kozloff, Lamanna, Lerner, Pashos, Sharman, and Weiss are members of Celgene Corporation’s Board of Directors or advisory committees. Flinn received research funding from Celgene Corporation. Flowers is a consultant for and received funding from Celgene Corporation, Prescription Solutions, Seattle Genetics, and Genentech.
PY - 2013/10
Y1 - 2013/10
N2 - Purpose: This analysis examined associations between gender and health-related quality of life (HRQOL) in patients with B-cell chronic lymphocytic leukemia (CLL) as they initiate therapy for CLL outside the clinical trial setting. Methods: Baseline data were collected as part of Connect® CLL Registry, a prospective observational study initiated in community, academic, and government centers. Patient demographics and clinical characteristics were provided by clinicians. Patients reported HRQOL using the Brief Fatigue Inventory (BFI), EQ-5D, and Functional Assessment of Cancer Therapy-Leukemia (FACT-Leu). Mean scores were analyzed, with statistical significance of differences determined by ANOVA. Multivariate analysis also considered age and line of therapy. Results: Baseline HRQOL data were available for 1,140 patients: 710 (62 %) men and 430 (38 %) women from 161 centers. Patients were predominantly white (89 %) with mean age 69 ± 11 years. Women reported significantly worse global fatigue (P <0.0001), fatigue severity (P <0.0001), and fatigue-related interference (P = 0.0005) versus men (BFI). Pain/discomfort (P = 0.0077), usual activities (P = 0.0015), and anxiety/depression (P = 0.0117) were significantly worse in women than in men (EQ-5D). With women reporting a better social/family score (P = 0.0238) and men reporting a better physical score (P = 0.0002), the mean FACT-G total score did not differ by gender. However, the mean FACT-Leu total score was better among men versus women (P = 0.0223), primarily because the mean leukemia subscale score was significantly better among men (P <0.0001). Multivariate analysis qualitatively confirmed these findings. Conclusions: Connect® CLL Registry results indicate that significant differences exist in certain HRQOL domains, as women reported greater levels of fatigue and worse functioning in physical domains.
AB - Purpose: This analysis examined associations between gender and health-related quality of life (HRQOL) in patients with B-cell chronic lymphocytic leukemia (CLL) as they initiate therapy for CLL outside the clinical trial setting. Methods: Baseline data were collected as part of Connect® CLL Registry, a prospective observational study initiated in community, academic, and government centers. Patient demographics and clinical characteristics were provided by clinicians. Patients reported HRQOL using the Brief Fatigue Inventory (BFI), EQ-5D, and Functional Assessment of Cancer Therapy-Leukemia (FACT-Leu). Mean scores were analyzed, with statistical significance of differences determined by ANOVA. Multivariate analysis also considered age and line of therapy. Results: Baseline HRQOL data were available for 1,140 patients: 710 (62 %) men and 430 (38 %) women from 161 centers. Patients were predominantly white (89 %) with mean age 69 ± 11 years. Women reported significantly worse global fatigue (P <0.0001), fatigue severity (P <0.0001), and fatigue-related interference (P = 0.0005) versus men (BFI). Pain/discomfort (P = 0.0077), usual activities (P = 0.0015), and anxiety/depression (P = 0.0117) were significantly worse in women than in men (EQ-5D). With women reporting a better social/family score (P = 0.0238) and men reporting a better physical score (P = 0.0002), the mean FACT-G total score did not differ by gender. However, the mean FACT-Leu total score was better among men versus women (P = 0.0223), primarily because the mean leukemia subscale score was significantly better among men (P <0.0001). Multivariate analysis qualitatively confirmed these findings. Conclusions: Connect® CLL Registry results indicate that significant differences exist in certain HRQOL domains, as women reported greater levels of fatigue and worse functioning in physical domains.
KW - Baseline data
KW - Chronic lymphocytic leukemia
KW - Community management
KW - Connect® CLL Registry
KW - Gender
KW - Health-related quality of life
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U2 - 10.1007/s00520-013-1854-z
DO - 10.1007/s00520-013-1854-z
M3 - Article
C2 - 23748484
AN - SCOPUS:84884267170
SN - 0941-4355
VL - 21
SP - 2853
EP - 2860
JO - Supportive Care in Cancer
JF - Supportive Care in Cancer
IS - 10
ER -