Association of health-related quality of life with gender in patients with B-cell chronic lymphocytic leukemia

Chris L. Pashos, Christopher R. Flowers, Neil E. Kay, Mark Weiss, Nicole Lamanna, Charles Farber, Susan Lerner, Jeff Sharman, David Grinblatt, Ian W. Flinn, Mark Kozloff, Arlene S. Swern, Thomas K. Street, Kristen A. Sullivan, Gale Harding, Zeba M. Khan

Research output: Contribution to journalArticlepeer-review

21 Scopus citations


Purpose: This analysis examined associations between gender and health-related quality of life (HRQOL) in patients with B-cell chronic lymphocytic leukemia (CLL) as they initiate therapy for CLL outside the clinical trial setting. Methods: Baseline data were collected as part of Connect® CLL Registry, a prospective observational study initiated in community, academic, and government centers. Patient demographics and clinical characteristics were provided by clinicians. Patients reported HRQOL using the Brief Fatigue Inventory (BFI), EQ-5D, and Functional Assessment of Cancer Therapy-Leukemia (FACT-Leu). Mean scores were analyzed, with statistical significance of differences determined by ANOVA. Multivariate analysis also considered age and line of therapy. Results: Baseline HRQOL data were available for 1,140 patients: 710 (62 %) men and 430 (38 %) women from 161 centers. Patients were predominantly white (89 %) with mean age 69 ± 11 years. Women reported significantly worse global fatigue (P <0.0001), fatigue severity (P <0.0001), and fatigue-related interference (P = 0.0005) versus men (BFI). Pain/discomfort (P = 0.0077), usual activities (P = 0.0015), and anxiety/depression (P = 0.0117) were significantly worse in women than in men (EQ-5D). With women reporting a better social/family score (P = 0.0238) and men reporting a better physical score (P = 0.0002), the mean FACT-G total score did not differ by gender. However, the mean FACT-Leu total score was better among men versus women (P = 0.0223), primarily because the mean leukemia subscale score was significantly better among men (P <0.0001). Multivariate analysis qualitatively confirmed these findings. Conclusions: Connect® CLL Registry results indicate that significant differences exist in certain HRQOL domains, as women reported greater levels of fatigue and worse functioning in physical domains.

Original languageEnglish (US)
Pages (from-to)2853-2860
Number of pages8
JournalSupportive Care in Cancer
Issue number10
StatePublished - Oct 2013


  • Baseline data
  • Chronic lymphocytic leukemia
  • Community management
  • Connect® CLL Registry
  • Gender
  • Health-related quality of life

ASJC Scopus subject areas

  • Oncology


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