Association of health-related quality of life and benign prostatic enlargement

C. J. Girman, S. J. Jacobsen, T. Rhodes, H. A. Guess, Rosebud O Roberts, M. M. Lieber

Research output: Contribution to journalArticle

53 Citations (Scopus)

Abstract

Objective: To investigate the association of benign prostatic enlargement and health-related quality of life (HRQoL) assessed by validated questionnaires. Method: Randomly selected men (n = 471) aged 40-79 years from Olmsted County, Minn. (USA) without prior prostate surgery or prostate cancer had a full urologic workup, including transrectal ultrasonography, in addition to completing questionnaires soliciting information about urinary symptom frequency, bother, degree of interference with daily activities and other measures of HRQoL. Results: Disease-specific HRQoL was worse in older men, and men with more severe symptoms. Age-adjusted mean scores for symptom severity, bother and activity interference were about 50% worse for men with enlarged prostates (volume > 40 cm3). After adjusting for age, men with enlarged prostates were nearly 3 times (95% CI 1.6, 5.1) as likely to have moderate to severe symptoms, and about twice as likely to have bother (odds ratio 2.4; 95% CI 1.3, 4.2) or activity interference (odds ratio 1.8; 95% CI 1.0, 3.2) relative to men with smaller prostates. Conclusion: HRQoL measures are worse in men who are older and, after adjusting for age, in men with increased urinary symptom frequency and enlarged prostate. The broader spectrum of patients provided by the community-based random sampling allows elucidation of these important relationships.

Original languageEnglish (US)
Pages (from-to)277-284
Number of pages8
JournalEuropean Urology
Volume35
Issue number4
StatePublished - 1999
Externally publishedYes

Fingerprint

Quality of Life
Prostate
Odds Ratio
Ultrasonography
Prostatic Neoplasms

Keywords

  • Community study
  • Epidemiology
  • Lower urinary tract symptoms
  • Prostate size
  • Prostatic hypertrophy
  • Quality of life

ASJC Scopus subject areas

  • Urology

Cite this

Girman, C. J., Jacobsen, S. J., Rhodes, T., Guess, H. A., Roberts, R. O., & Lieber, M. M. (1999). Association of health-related quality of life and benign prostatic enlargement. European Urology, 35(4), 277-284.

Association of health-related quality of life and benign prostatic enlargement. / Girman, C. J.; Jacobsen, S. J.; Rhodes, T.; Guess, H. A.; Roberts, Rosebud O; Lieber, M. M.

In: European Urology, Vol. 35, No. 4, 1999, p. 277-284.

Research output: Contribution to journalArticle

Girman, CJ, Jacobsen, SJ, Rhodes, T, Guess, HA, Roberts, RO & Lieber, MM 1999, 'Association of health-related quality of life and benign prostatic enlargement', European Urology, vol. 35, no. 4, pp. 277-284.
Girman CJ, Jacobsen SJ, Rhodes T, Guess HA, Roberts RO, Lieber MM. Association of health-related quality of life and benign prostatic enlargement. European Urology. 1999;35(4):277-284.
Girman, C. J. ; Jacobsen, S. J. ; Rhodes, T. ; Guess, H. A. ; Roberts, Rosebud O ; Lieber, M. M. / Association of health-related quality of life and benign prostatic enlargement. In: European Urology. 1999 ; Vol. 35, No. 4. pp. 277-284.
@article{b2d8d9e3ca3847028d04383f05e35846,
title = "Association of health-related quality of life and benign prostatic enlargement",
abstract = "Objective: To investigate the association of benign prostatic enlargement and health-related quality of life (HRQoL) assessed by validated questionnaires. Method: Randomly selected men (n = 471) aged 40-79 years from Olmsted County, Minn. (USA) without prior prostate surgery or prostate cancer had a full urologic workup, including transrectal ultrasonography, in addition to completing questionnaires soliciting information about urinary symptom frequency, bother, degree of interference with daily activities and other measures of HRQoL. Results: Disease-specific HRQoL was worse in older men, and men with more severe symptoms. Age-adjusted mean scores for symptom severity, bother and activity interference were about 50{\%} worse for men with enlarged prostates (volume > 40 cm3). After adjusting for age, men with enlarged prostates were nearly 3 times (95{\%} CI 1.6, 5.1) as likely to have moderate to severe symptoms, and about twice as likely to have bother (odds ratio 2.4; 95{\%} CI 1.3, 4.2) or activity interference (odds ratio 1.8; 95{\%} CI 1.0, 3.2) relative to men with smaller prostates. Conclusion: HRQoL measures are worse in men who are older and, after adjusting for age, in men with increased urinary symptom frequency and enlarged prostate. The broader spectrum of patients provided by the community-based random sampling allows elucidation of these important relationships.",
keywords = "Community study, Epidemiology, Lower urinary tract symptoms, Prostate size, Prostatic hypertrophy, Quality of life",
author = "Girman, {C. J.} and Jacobsen, {S. J.} and T. Rhodes and Guess, {H. A.} and Roberts, {Rosebud O} and Lieber, {M. M.}",
year = "1999",
language = "English (US)",
volume = "35",
pages = "277--284",
journal = "European Urology",
issn = "0302-2838",
publisher = "Elsevier",
number = "4",

}

TY - JOUR

T1 - Association of health-related quality of life and benign prostatic enlargement

AU - Girman, C. J.

AU - Jacobsen, S. J.

AU - Rhodes, T.

AU - Guess, H. A.

AU - Roberts, Rosebud O

AU - Lieber, M. M.

PY - 1999

Y1 - 1999

N2 - Objective: To investigate the association of benign prostatic enlargement and health-related quality of life (HRQoL) assessed by validated questionnaires. Method: Randomly selected men (n = 471) aged 40-79 years from Olmsted County, Minn. (USA) without prior prostate surgery or prostate cancer had a full urologic workup, including transrectal ultrasonography, in addition to completing questionnaires soliciting information about urinary symptom frequency, bother, degree of interference with daily activities and other measures of HRQoL. Results: Disease-specific HRQoL was worse in older men, and men with more severe symptoms. Age-adjusted mean scores for symptom severity, bother and activity interference were about 50% worse for men with enlarged prostates (volume > 40 cm3). After adjusting for age, men with enlarged prostates were nearly 3 times (95% CI 1.6, 5.1) as likely to have moderate to severe symptoms, and about twice as likely to have bother (odds ratio 2.4; 95% CI 1.3, 4.2) or activity interference (odds ratio 1.8; 95% CI 1.0, 3.2) relative to men with smaller prostates. Conclusion: HRQoL measures are worse in men who are older and, after adjusting for age, in men with increased urinary symptom frequency and enlarged prostate. The broader spectrum of patients provided by the community-based random sampling allows elucidation of these important relationships.

AB - Objective: To investigate the association of benign prostatic enlargement and health-related quality of life (HRQoL) assessed by validated questionnaires. Method: Randomly selected men (n = 471) aged 40-79 years from Olmsted County, Minn. (USA) without prior prostate surgery or prostate cancer had a full urologic workup, including transrectal ultrasonography, in addition to completing questionnaires soliciting information about urinary symptom frequency, bother, degree of interference with daily activities and other measures of HRQoL. Results: Disease-specific HRQoL was worse in older men, and men with more severe symptoms. Age-adjusted mean scores for symptom severity, bother and activity interference were about 50% worse for men with enlarged prostates (volume > 40 cm3). After adjusting for age, men with enlarged prostates were nearly 3 times (95% CI 1.6, 5.1) as likely to have moderate to severe symptoms, and about twice as likely to have bother (odds ratio 2.4; 95% CI 1.3, 4.2) or activity interference (odds ratio 1.8; 95% CI 1.0, 3.2) relative to men with smaller prostates. Conclusion: HRQoL measures are worse in men who are older and, after adjusting for age, in men with increased urinary symptom frequency and enlarged prostate. The broader spectrum of patients provided by the community-based random sampling allows elucidation of these important relationships.

KW - Community study

KW - Epidemiology

KW - Lower urinary tract symptoms

KW - Prostate size

KW - Prostatic hypertrophy

KW - Quality of life

UR - http://www.scopus.com/inward/record.url?scp=0033067664&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033067664&partnerID=8YFLogxK

M3 - Article

C2 - 10087388

AN - SCOPUS:0033067664

VL - 35

SP - 277

EP - 284

JO - European Urology

JF - European Urology

SN - 0302-2838

IS - 4

ER -