TY - JOUR
T1 - Association of Genetic Ancestry with Terminal Duct Lobular Unit Involution among Healthy Women
AU - Sung, Hyuna
AU - Koka, Hela
AU - Marino, Natascia
AU - Pfeiffer, Ruth M.
AU - Cora, Renata
AU - Figueroa, Jonine D.
AU - Sherman, Mark E.
AU - Gierach, Gretchen L.
AU - Yang, Xiaohong R.
N1 - Publisher Copyright:
© 2022 Published by Oxford University Press. This work is written by US Government employees and is in the public domain in the US.
PY - 2022/10/1
Y1 - 2022/10/1
N2 - Reduced age-related terminal duct lobular unit (TDLU) involution has been linked to increased breast cancer risk and triple-negative breast cancer. Associations of TDLU involution levels with race and ethnicity remain incompletely explored. Herein, we examined the association between genetic ancestry and TDLU involution in normal breast tissue donated by 2014 healthy women in the United States. Women of African ancestry were more likely than European women to have increased TDLU counts (odds ratio [OR]trend = 1.36, 95% confidence interval [CI] = 1.07 to 1.74), acini counts per TDLU (OR = 1.47, 95% CI = 1.06 to 2.03), and median TDLU span (ORtrend = 1.44, 95% CI = 1.08 to 1.91), indicating lower involution, whereas East Asian descendants were associated with decreased TDLU counts (ORtrend = 0.52, 95% CI = 0.35 to 0.78) after controlling for potential confounders. These associations are consistent with the racial variations in incidence rates of triple-negative breast cancer in the United States and suggest opportunities for future work examining whether TDLU involution may mediate the racial differences in subtype-specific breast cancer risk.
AB - Reduced age-related terminal duct lobular unit (TDLU) involution has been linked to increased breast cancer risk and triple-negative breast cancer. Associations of TDLU involution levels with race and ethnicity remain incompletely explored. Herein, we examined the association between genetic ancestry and TDLU involution in normal breast tissue donated by 2014 healthy women in the United States. Women of African ancestry were more likely than European women to have increased TDLU counts (odds ratio [OR]trend = 1.36, 95% confidence interval [CI] = 1.07 to 1.74), acini counts per TDLU (OR = 1.47, 95% CI = 1.06 to 2.03), and median TDLU span (ORtrend = 1.44, 95% CI = 1.08 to 1.91), indicating lower involution, whereas East Asian descendants were associated with decreased TDLU counts (ORtrend = 0.52, 95% CI = 0.35 to 0.78) after controlling for potential confounders. These associations are consistent with the racial variations in incidence rates of triple-negative breast cancer in the United States and suggest opportunities for future work examining whether TDLU involution may mediate the racial differences in subtype-specific breast cancer risk.
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U2 - 10.1093/jnci/djac063
DO - 10.1093/jnci/djac063
M3 - Article
C2 - 35333343
AN - SCOPUS:85139572796
SN - 0027-8874
VL - 114
SP - 1420
EP - 1424
JO - Journal of the National Cancer Institute
JF - Journal of the National Cancer Institute
IS - 10
ER -