Association of gastric emptying with postprandial appetite and satiety sensations in obesity

Objective: Satiety, defined as the duration of the sensation of fullness, is usually measured by validated visual analog scales (VAS) for appetite. Gastric function plays a key role in food intake regulation. However, the association between gastric emptying (GE) and VAS appetite is unknown. Methods: In this cross-sectional study, 134 participants (mean [SEM] age = 39 [0.8] years, mean [SEM] BMI = 38 [0.5] kg/m², 67% females) completed simultaneous measurements of GE and VAS appetite. After a 320-kcal meal, GE was measured by scintigraphy and appetite by validated 100-mm VAS for 240 minutes. Satiation was defined as calories consumed to terminate meal and was measured by an ad libitum meal. GE, VAS, and ad libitum meal tests were measured on the same day. Percent of meal retention in the stomach, VAS area under curve (AUC_{0-240 min}), and overall appetite score (OAS) were calculated. Pearson correlation (ρ) determined the association of GE with VAS appetite and satiation. Appetite components were also analyzed by quartiles based on GE_{120 min}. Results: GE_{120 min} was correlated with sensation of VAS hunger_{AUC(0-240 min)} (ρ = 0.24, p = 0.004), fullness_{AUC(0-240 min)} (ρ = 0.16, p = 0.05), and OAS_{AUC(0-240 min)} (ρ = 0.20, p = 0.02). Patients with rapid GE_{120 min} had a mean increase in VAS hunger_{AUC(0-240 min)} by 32 mm/min (15.62%, p = 0.03) compared with normal/slow GE_{120 min}. Conclusions: GE is associated with the sensations of appetite, and rapid GE is associated with increased appetite, which may contribute to weight gain.