@article{fcd9a6c9488d4759a97016b19dc2adb9,
title = "Association of exercise with quality of life and mood symptoms in a comparative effectiveness study of bipolar disorder",
abstract = "Background Individuals with bipolar disorder lead a sedentary lifestyle associated with worse course of illness and recurrence of symptoms. Identifying potentially modifiable predictors of exercise frequency could lead to interventions with powerful consequences on the course of illness and overall health. Methods The present study examines baseline reports of exercise frequency of bipolar patients in a multi-site comparative effectiveness study of a second generation antipsychotic (quetiapine) versus a classic mood stabilizer (lithium). Demographics, quality of life, functioning, and mood symptoms were assessed. Results Approximately 40% of participants reported not exercising regularly (at least once per week). Less frequent weekly exercise was associated with higher BMI, more time depressed, more depressive symptoms, and lower quality of life and functioning. In contrast, more frequent exercise was associated with experiencing more mania in the past year and more current manic symptoms. Limitations Exercise frequency was measured by self-report and details of the exercise were not collected. Analyses rely on baseline data, allowing only for association analyses. Directionality and predictive validity cannot be determined. Data were collected in the context of a clinical trial and thus, it is possible that the generalizability of the findings could be limited. Conclusion There appears to be a mood-specific relationship between exercise frequency and polarity such that depression is associated with less exercise and mania with more exercise in individuals with bipolar disorder. This suggests that increasing or decreasing exercise could be a targeted intervention for patients with depressive or mood elevation symptoms, respectively.",
keywords = "Bipolar disorder, Exercise, Functioning, Mood symptoms, Quality of life",
author = "Sylvia, {Louisa G.} and Friedman, {Edward S.} and Kocsis, {James H.} and Bernstein, {Emily E.} and Brody, {Benjamin D.} and Gustavo Kinrys and Kemp, {David E.} and Shelton, {Richard C.} and McElroy, {Susan L.} and Bobo, {William V.} and Masoud Kamali and McInnis, {Melvin G.} and Mauricio Tohen and Bowden, {Charles L.} and Ketter, {Terence A.} and Thilo Deckersbach and Calabrese, {Joseph R.} and Thase, {Michael E.} and Reilly-Harrington, {Noreen A.} and Vivek Singh and Rabideau, {Dustin J.} and Nierenberg, {Andrew A.}",
note = "Funding Information: Dr. Kocsis has received research grants and contracts from AHRQ, NIMH, NIDA, Burroughs Wellcome Trust, Pritzker Consortium, Takeda, Forest, Astra Zeneca, Roche. He is on the speaker′s bureau at Pfizer and Merck and on the advisory board at Corcept. Funding Information: Dr. Shelton has served as a consultant to Bristol-Myers Squibb, Cyberonics, Inc., Elan, Corp., Eli Lilly and Company, Euthymics Bioscience, Forest Pharmaceuticals, Janssen Pharmaceutica, Medtronic, Inc., Otsuka Pharmaceuticals, Pamlab, Inc., Pfizer, Inc., Ridge Diagnostics, Takeda Pharmaceuticals. Dr. Shelton has received research grant support from Appian Labs, Bristol-Myers Squibb, Elan, Corp., Eli Lilly and Company, Euthymics Bioscience, Forest Pharmaceuticals, Janssen Pharmaceutica, Naurex, Inc., Novartis Pharmaceuticals, Otsuka Pharmaceuticals, Pamlab, Inc., Repligen, Corp., Ridge Diagnostics, St. Jude Medical, Inc., Takeda Pharmaceuticals. Funding Information: Dr. Brody has received salary support over the past 3 years from grants funded by Forrest, Agency for Healthcare Quality and Research, and Pritzker neuropsychiatric disorders research consortium. Funding Information: Dr. Friedman r eceives grant support from Repligen, Astra-Zeneca, Roche, Takeda, Neosync. He has been a consultant for Pamlab. He receives royalties from Springer. He has served as an expert forensic consultant for Thomson Rhodes & Cowie P.C. and Berger and Zavesky Co. L.P.A. ",
year = "2013",
month = nov,
doi = "10.1016/j.jad.2013.07.031",
language = "English (US)",
volume = "151",
pages = "722--727",
journal = "Journal of Affective Disorders",
issn = "0165-0327",
publisher = "Elsevier",
number = "2",
}