Association of elevated serumfree light chains with chronic lymphocytic leukemia and monoclonal B-cell lymphocytosis

Alyssa I. Clay-Gilmour, Abdul R. Rishi, Lynn R. Goldin, Alexandra J. Greenberg-Worisek, Sara J. Achenbach, Kari G. Rabe, Matthew J. Maurer, Neil E. Kay, Tait D. Shanafelt, Timothy G. Call, J. Brice Weinberg, Nicola J. Camp, James R. Cerhan, Jose Leis, Aaron Norman, David L. Murray, S. Vincent Rajkumar, Neil E. Caporaso, Ola Landgren, Mary L. McMasterSusan L. Slager, Celine M. Vachon

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Abstract

Chronic lymphocytic leukemia (CLL) and its precursor, monoclonal B-cell lymphocytosis (MBL), are heritable. Serumfree light-chain (sFLC) measures are a prognostic factor for CLL, but their role in susceptibility to CLL is not clear. We investigated differences between sFLC measurements in pre-treatment serum from five groups to inform the association of sFLC with familial and sporadic CLL: (1) familial CLL (n = 154), (2) sporadic CLL (n = 302), (3) familial MBL (n = 87), (4) unaffected first-degree relatives from CLL/MBL families (n = 263), and (5) reference population (n = 15,396). The percent of individuals having elevated monoclonal and polyclonal sFLCs was compared using age-stratified and age- and sex-adjusted logistic regression models. In age groups >50 years, monoclonal sFLC elevations were increased in sporadic and familial CLL cases compared to the reference population (p’s < 0.05). However, there were no statistically significant differences in sFLC monoclonal or polyclonal elevations between familial and sporadic CLL cases (p’s > 0.05). Unaffected relatives and MBL cases from CLL/MBL families, ages >60 years, showed elevated monoclonal sFLC, compared to the reference population (p’s < 0.05). This is the first study to demonstrate monoclonal sFLC elevations in CLL cases compared to controls. Monoclonal sFLC levels may provide additional risk information in relatives of CLL probands.

Original languageEnglish (US)
Article number59
JournalBlood cancer journal
Volume9
Issue number8
DOIs
StatePublished - Aug 1 2019

ASJC Scopus subject areas

  • Hematology
  • Oncology

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    Clay-Gilmour, A. I., Rishi, A. R., Goldin, L. R., Greenberg-Worisek, A. J., Achenbach, S. J., Rabe, K. G., Maurer, M. J., Kay, N. E., Shanafelt, T. D., Call, T. G., Brice Weinberg, J., Camp, N. J., Cerhan, J. R., Leis, J., Norman, A., Murray, D. L., Vincent Rajkumar, S., Caporaso, N. E., Landgren, O., ... Vachon, C. M. (2019). Association of elevated serumfree light chains with chronic lymphocytic leukemia and monoclonal B-cell lymphocytosis. Blood cancer journal, 9(8), [59]. https://doi.org/10.1038/s41408-019-0220-x