Association of early life exposure to phthalates with obesity and cardiometabolic traits in childhood: Sex specific associations

Marina Vafeiadi, Antonis Myridakis, Theano Roumeliotaki, Katerina Margetaki, Georgia Chalkiadaki, Eirini Dermitzaki, Maria Venihaki, Katerina Sarri, Maria Vassilaki, Vasiliki Leventakou, Euripides G. Stephanou, Manolis Kogevinas, Leda Chatzi

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Few studies have investigated longitudinal associations between early life phthalate exposure and subsequent obesity and cardiovascular risks in children with inconsistent results. We aimed to evaluate the associations between phthalate exposure during gestation and childhood with offspring obesity and cardiometabolic risk factors in 500 mother-child pairs from the Rhea pregnancy cohort in Crete, Greece. Seven phthalate metabolites [monoethyl phthalate (MEP), mono-n-butyl phthalate (MnBP), mono-isobutyl phthalate (MiBP), monobenzyl phthalate (MBzP), mono(2-ethylhexyl) phthalate (MEHP), mono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP), and mono(2-ethyl-5-oxohexyl) phthalate (MEOHP)] were quantified in spot urine samples collected from mothers (1st trimester) and their children at 4 years of age. We calculated the molar sum of DEHP metabolites (MEHP, MEHHP, MEOHP). We measured child weight, height, waist circumference, skinfold thicknesses, blood pressure (BP), and lipids at 4 and 6 years and leptin, adiponectin, and C-reactive protein at 4 years. We used generalized estimating equations to examine associations at each age and tested for interaction by sex. Child exposure to phthalate metabolites was associated with lower BMI z-scores in boys and higher BMI z-scores in girls. Each 10-fold increase in ΣDEHP was associated with a change in waist circumference of -2.6 cm (95% CI: -4.72, -0.48) in boys vs. 2.14 cm (95% CI: -0.14, 4.43) in girls (p-sex interaction = 0.003) and a change in waist-to-height ratio of -0.01 (95% CI: -0.03, 0.01) in boys vs. 0.02 (95% CI: 0.01, 0.04) in girls (p-sex interaction = 0.006). Phthalate metabolite concentrations at age 4 were negatively associated with systolic and diastolic blood pressure. MEP was associated with lower systolic BP z-scores (adj. β = -0.22; 95% CI: -0.36, -0.08) at 4 years. MnBP and MBzP were associated with lower diastolic BP z-scores (adj. β = -0.13; 95%CI: -0.23, -0.04, and adj. β = -0.11; 95% CI: -0.21, -0.01, respectively). A 10-fold increase in MiBP was associated with 4.4% higher total cholesterol levels (95% CI: 0.2, 8.7). Prenatal phthalate exposure was not consistently associated with child adiposity and cardiometabolic measures. Our findings suggest that early life phthalate exposure may affect child growth and adiposity in a sex-specific manner and depends on the timing of exposure.

Original languageEnglish (US)
Article number327
JournalFrontiers in Public Health
Volume6
Issue numberNOV
DOIs
StatePublished - Nov 27 2018

Fingerprint

Obesity
Blood Pressure
Diethylhexyl Phthalate
Greece
Adiposity
Waist Circumference
Rheiformes
Mothers
phthalic acid
Pregnancy
Skinfold Thickness
Adiponectin
Leptin
Hypercholesterolemia
C-Reactive Protein
Urine
Lipids
Weights and Measures
Growth

Keywords

  • Cardiometabolic risk
  • Children
  • Obesity
  • Phthalates
  • Pregnancy

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health

Cite this

Vafeiadi, M., Myridakis, A., Roumeliotaki, T., Margetaki, K., Chalkiadaki, G., Dermitzaki, E., ... Chatzi, L. (2018). Association of early life exposure to phthalates with obesity and cardiometabolic traits in childhood: Sex specific associations. Frontiers in Public Health, 6(NOV), [327]. https://doi.org/10.3389/fpubh.2018.00327

Association of early life exposure to phthalates with obesity and cardiometabolic traits in childhood : Sex specific associations. / Vafeiadi, Marina; Myridakis, Antonis; Roumeliotaki, Theano; Margetaki, Katerina; Chalkiadaki, Georgia; Dermitzaki, Eirini; Venihaki, Maria; Sarri, Katerina; Vassilaki, Maria; Leventakou, Vasiliki; Stephanou, Euripides G.; Kogevinas, Manolis; Chatzi, Leda.

In: Frontiers in Public Health, Vol. 6, No. NOV, 327, 27.11.2018.

Research output: Contribution to journalArticle

Vafeiadi, M, Myridakis, A, Roumeliotaki, T, Margetaki, K, Chalkiadaki, G, Dermitzaki, E, Venihaki, M, Sarri, K, Vassilaki, M, Leventakou, V, Stephanou, EG, Kogevinas, M & Chatzi, L 2018, 'Association of early life exposure to phthalates with obesity and cardiometabolic traits in childhood: Sex specific associations', Frontiers in Public Health, vol. 6, no. NOV, 327. https://doi.org/10.3389/fpubh.2018.00327
Vafeiadi, Marina ; Myridakis, Antonis ; Roumeliotaki, Theano ; Margetaki, Katerina ; Chalkiadaki, Georgia ; Dermitzaki, Eirini ; Venihaki, Maria ; Sarri, Katerina ; Vassilaki, Maria ; Leventakou, Vasiliki ; Stephanou, Euripides G. ; Kogevinas, Manolis ; Chatzi, Leda. / Association of early life exposure to phthalates with obesity and cardiometabolic traits in childhood : Sex specific associations. In: Frontiers in Public Health. 2018 ; Vol. 6, No. NOV.
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abstract = "Few studies have investigated longitudinal associations between early life phthalate exposure and subsequent obesity and cardiovascular risks in children with inconsistent results. We aimed to evaluate the associations between phthalate exposure during gestation and childhood with offspring obesity and cardiometabolic risk factors in 500 mother-child pairs from the Rhea pregnancy cohort in Crete, Greece. Seven phthalate metabolites [monoethyl phthalate (MEP), mono-n-butyl phthalate (MnBP), mono-isobutyl phthalate (MiBP), monobenzyl phthalate (MBzP), mono(2-ethylhexyl) phthalate (MEHP), mono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP), and mono(2-ethyl-5-oxohexyl) phthalate (MEOHP)] were quantified in spot urine samples collected from mothers (1st trimester) and their children at 4 years of age. We calculated the molar sum of DEHP metabolites (MEHP, MEHHP, MEOHP). We measured child weight, height, waist circumference, skinfold thicknesses, blood pressure (BP), and lipids at 4 and 6 years and leptin, adiponectin, and C-reactive protein at 4 years. We used generalized estimating equations to examine associations at each age and tested for interaction by sex. Child exposure to phthalate metabolites was associated with lower BMI z-scores in boys and higher BMI z-scores in girls. Each 10-fold increase in ΣDEHP was associated with a change in waist circumference of -2.6 cm (95{\%} CI: -4.72, -0.48) in boys vs. 2.14 cm (95{\%} CI: -0.14, 4.43) in girls (p-sex interaction = 0.003) and a change in waist-to-height ratio of -0.01 (95{\%} CI: -0.03, 0.01) in boys vs. 0.02 (95{\%} CI: 0.01, 0.04) in girls (p-sex interaction = 0.006). Phthalate metabolite concentrations at age 4 were negatively associated with systolic and diastolic blood pressure. MEP was associated with lower systolic BP z-scores (adj. β = -0.22; 95{\%} CI: -0.36, -0.08) at 4 years. MnBP and MBzP were associated with lower diastolic BP z-scores (adj. β = -0.13; 95{\%}CI: -0.23, -0.04, and adj. β = -0.11; 95{\%} CI: -0.21, -0.01, respectively). A 10-fold increase in MiBP was associated with 4.4{\%} higher total cholesterol levels (95{\%} CI: 0.2, 8.7). Prenatal phthalate exposure was not consistently associated with child adiposity and cardiometabolic measures. Our findings suggest that early life phthalate exposure may affect child growth and adiposity in a sex-specific manner and depends on the timing of exposure.",
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T2 - Sex specific associations

AU - Vafeiadi, Marina

AU - Myridakis, Antonis

AU - Roumeliotaki, Theano

AU - Margetaki, Katerina

AU - Chalkiadaki, Georgia

AU - Dermitzaki, Eirini

AU - Venihaki, Maria

AU - Sarri, Katerina

AU - Vassilaki, Maria

AU - Leventakou, Vasiliki

AU - Stephanou, Euripides G.

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