Association of cytomegalovirus infection and disease with death and graft loss after liver transplant in high-risk recipients

W. Bosch, M. G. Heckman, N. N. Diehl, J. A. Shalev, S. Pungpapong, W. C. Hellinger

Research output: Contribution to journalArticle

29 Scopus citations

Abstract

In the era of effective antiviral chemoprophylaxis, cytomegalovirus (CMV) disease has been inconsistently associated with increased mortality in liver transplant (LT) recipients. A retrospective study evaluating the association of CMV infection and disease occurring within 1 year of transplant with the endpoints of death or the combined endpoint of graft loss or death was undertaken in a cohort of 227 CMV donor seropositive, recipient seronegative first LT recipients. Associations were evaluated using Cox proportional hazards regression models. CMV infection and disease occurred in 91 (40%) and 43 (19%) patients, respectively. Forty-eight (21%) died while 58 (26%) sustained graft loss or death. In multivariable analysis, CMV infection was associated with an increased risk of death (RR: 2.24, p = 0.008) and graft loss or death (RR: 2.85, p < 0.001). CMV disease was also associated with an increased risk of death (RR: 2.73, p = 0.003) and graft loss or death (RR: 3.04, p = 0.001). CMV infection and disease occurring within the first year after LT in high-risk recipients is associated with increased risk of death and of graft loss or death. Investigation of strategies to further reduce the risk of CMV infection and disease in high-risk LT recipients is warranted.

Original languageEnglish (US)
Pages (from-to)2181-2189
Number of pages9
JournalAmerican Journal of Transplantation
Volume11
Issue number10
DOIs
StatePublished - Oct 1 2011

Keywords

  • Cytomegalovirus (CMV)
  • death
  • graft failure
  • graft loss
  • liver transplantation
  • mortality

ASJC Scopus subject areas

  • Immunology and Allergy
  • Transplantation
  • Pharmacology (medical)

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